LAS VEGAS (AP) -Manny Pacquiao is getting ready for one of the biggest nights of his life. He has spent hundreds of hours sparring in sweltering gyms and taking morning runs through deserted streets.

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He will be facing Miguel Cotto, who hasn't exactly been a slacker himself. The Puerto Rican welterweight champion had to get 2 pounds under his normal weight for the richest and biggest fight of his career.

The winner of Saturday night's highly anticipated 145-pound bout could get a megafight against undefeated Floyd Mayweather Jr.

Pacquiao is a 2 1/2-1 favorite in the scheduled 12-rounder from the sold-out MGM Grand arena. The bout will be televised on pay-per-view.