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For the first time since Week 1, there will be two live play-by-play games available for betting on Friday in Week 6 of college football to kick off the weekend.

The early start (7:15 p.m. ET) is Pittsburgh at Syracuse in their final Big East matchup - the two schools head to the ACC next season and will play each other each year despite being in different division (as primary crossover rivals). The Panthers are 2-point favorites for this one with the total at 58.

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Pitt first-year coach Paul Chryst was under a bit of fire after the Panthers started 0-2, including a loss to a FCS school, but they have bounced back with easy wins over then-No. 13 Virginia Tech and FCS school Gardner-Webb. The Pittsburgh offense has taken off of late, producing back-to-back games with at least 500 yards for the first time in 20 years. QB Tino Sunseri appears to have adapted to Chryst's system by completing 71 percent of his passes with six scores and just one pick in the victories.

This will be the Big East opener for the Orange (1-3), who are looking for their first win over an FBS school in 2012. Overall, SU has lost eight of its last nine games (1-8 ATS). And Syracuse has had no luck vs. Pittsburgh, dropping seven in a row in the series. The total has gone over in SU's two home games vs. FBS foes this year and the over has hit in four of the past five in this series at the Carrier Dome.

Utah State at BYU (-7, 45): The Aggies, already having beaten Utah, go for a sweep of their Beehive State FBS rivals with an upset in Provo and earn the Beehive Boot. However, USU hasn't beaten BYU in Provo since 1978.

BYU (3-2) appears to have found its quarterback of the future in freshman Taysom Hill. Making his first start last week in place of an injured Riley Nelson, Hill completed 12 of 21 passes for 112 yards with two touchdowns and one interception, and he rushed 15 times for 141 yards and a touchdown in a 47-0 blowout of Hawaii. Hill is likely to start again with Nelson still beaten up.

Utah State (4-1) is one of a handful of teams remaining in the country without an ATS loss this season. Last week in a 35-13 win over UNLV, QB Chuckie Keeton had his career-best game by completing 20 of 33 passes for 402 yards and four touchdowns. USU lost 27-24 at BYU last year but has covered its past four vs. the Cougars.

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No. 24 Northwestern at Penn State (-3, 48.5): Northwestern returned to the Top 25 of the AP poll this week for the first time since the end of the 2008 regular season. NU has one of the most versatile players in the nation in quarterback/receiver Kain Colter. Last week in a 44-29 win over Indiana, Colter ran for 161 yards and four touchdowns and had 131 yards receiving; he also attempted three passes. Northwestern set a school record with 704 yards of total offense.

Under arguably the most difficult circumstances in NCAA history, first-year coach Bill O'Brien has led Penn State to three straight wins after two close losses to open the season. The Nittany Lions, who aren't eligible for the postseason, opened Big Ten play last week with a 35-7 blowout at Illinois.

PSU is now looking to beat a ranked opponent at Beaver Stadium for the first time since 2008. A victory over the Nittany Lions would give the Wildcats their first 6-0 start to a season since 1962. Northwestern hasn't beaten Penn State in eight years and hasn't covered in the past four meetings.

No. 4 LSU at No. 10 Florida (+3, 44.5): LSU brings the nation's longest regular-season winning streak of 18 games into Saturday's huge showdown with Florida in a potential preview of December's SEC Championship Game.

The Tigers have slipped from No. 2 to No. 4 in the polls after back-to-back unimpressive efforts. For example, in last week's 38-22 win over FCS school Towson, LSU put the ball on the ground five times, its most since 1997. LSU lost three of those fumbles and lost the time of possession battle by nearly 10 minutes.

Florida had last week off to prepare for this one. The Gators are 1-7 in October the past two years and lost 44-11 in Baton Rouge last year. This is the ninth straight year these teams meet with both ranked. LSU is looking for its third straight win in the series for the first time since 1977-80. UF has covered just one of its past seven home games overall, while LSU has covered six of its past seven on the road.

No. 8 West Virginia at No. 11 Texas (-7, 75): WVU makes its first visit to Austin in 56 years for its first-ever Big 12 road game as it visits Texas in a game that has easily the highest total of any in Week 6.

This features the top two passers in the nation in efficiency, WVU's Geno Smith and Texas' David Ash. Smith, the Heisman favorite, broke nearly every school record last week by completing 45 of 51 passes for 656 yards and eight touchdowns in a 70-63 win over Baylor, the highest-scoring Big 12 game in history. WVU leads the nation in passing, is third in scoring and has scored at least 69 points in three of its past five games dating to last season's Orange Bowl.

Texas was offensively challenged last year but is No. 9 in scoring in 2012 behind Ash. Last year while splitting time with Case McCoy, Ash completed less than 57 percent of his passes with four touchdowns and eight picks. In the past two games alone this season, Ash is completing better than 81 percent for 630 yards with seven touchdowns and one interception (his lone this year).

No. 23 Washington at No. 2 Oregon (-24, 65): After upsetting then-No. 8 Stanford last week, Washington could take a huge step toward a potential Pac-12 North title by pulling a stunner over the Ducks in the final kickoff of Saturday night.

A win here would give UW victories over the North's presumed two top teams. The Huskies still must play ranked USC and Oregon State, but both schools visit Seattle (Trojans next week). Washington will try and keep the potent Oregon offense off the field. In the upset of Stanford, Huskies running back Bishop Sankey rushed for 144 yards vs. Stanford, more than the Cardinal had allowed in their first three games combined. Running the ball successfully would help eat the clock vs. the Ducks.

Oregon was a bit sloppy in last week's 51-26 win over Washington State in Seattle - the Cougars were only down four at halftime. Meanwhile, Oregon has won the last eight meetings against Washington by an average of 25 points a game and has covered in all but one of them.

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