The inaugural game took place in 2005 from Orlando, Florida with Tulsa defeating Central Florida 44-27 as a three-point road favorite. Including this win, the road team has gone 3-4 in the C-USA championship. The underdog has produced a 4-3 record against the spread during this span and the 'over' has also produced a 4-3 mark as well.

In 2011, Southern Mississippi knocked off Houston as a 12 ½-point road underdog, which was tied for the largest upset in C-USA championship history. In 2008, East Carolina stunned Tulsa 27-24 with the same point-spread.

Since the championship started, the East Division owns a 5-2 straight up record over the West and there hasn't been much change with the teams playing in this title game. Only six of the 12 schools in Conference USA have made an appearance. East Carolina and Central Florida have both won the championship twice, the only two to have multiple titles.