OAKLAND, Calif. (AP) - Guillermo Moscoso had nothing to show for the best outing yet of his young career. That's only because home run leader Jose Bautista got a hold of one.

It wasn't even a bad pitch.

Moscoso allowed three hits over a career-high eight innings, including Bautista's majors-best 36th home run, but the Oakland Athletics couldn't figure out Toronto's Luis Perez and Casey Janssen and were one-hit in a 1-0 loss to the Blue Jays on Sunday.

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``Sometimes you're going to have great days like this and you're going to get the loss,' said Moscoso, who struck out seven and walked one. ``That was today.'

Perez worked out of a bases-loaded jam in the sixth and pitched brilliantly in his first start at this level.

Bautista broke up a scoreless game with a deep drive into the left-field bleachers on the 10th pitch he saw from Moscoso (6-7) leading off the seventh.

Perez (3-2) didn't allow an A's runner until Cliff Pennington drew a five-pitch walk to start the sixth. Jemile Weeks later singled up the middle to load the bases, but Perez induced an inning-ending double play by Coco Crisp with his final pitch.

``When you have well-pitched games like that it looks like the offense is down and dragging a little bit,' A's manager Bob Melvin said. ``But both pitchers were terrific. One pitch ended up deciding the game. ... When you get a performance like that from your starting pitcher, you'd like to reward him.'

Perez had made 29 relief appearances this season and was a starter throughout his minor league career.

The 26-year-old left-hander - Oakland's ninth opposing lefty starter in 14 games - struck out four and walked two while throwing 80 pitches in six innings. He baffled Oakland's hitters with a fastball that moved and also mixed in his changeup.

Pretty good for a guy who hadn't gone more than four innings since May 15 while in Triple-A. For his career, he had only eight appearances of two or more innings in the big leagues.

Perez said he didn't think about being perfect or his no-hit bid but rather to keep attacking hitters.

``I hadn't started a game and I didn't know how far I was going to go,' Perez said. ``Mentally I stayed strong. Each inning I pitched better and better. I kept attacking hitters and throwing strikes.'

Janssen struck out five in three innings, earning his second save in three chances this season and ninth of his career. Closer Frank Francisco warmed up but his shoulder stiffened up and he couldn't go.

Perez got some nice early help from his defense.

Weeks hit a flare to right field to begin the fourth that looked like it might fall in, but Bautista - who was a late scratch for Saturday night's loss with tightness in his neck - made a sliding catch for the out.

Two batters later, Perez fell behind 2-0 to Hideki Matsui before coming back to retire the A's designated hitter on a swinging strikeout.

Bautista made another tough play with a backhanded grab after running down Brandon Allen's deep fly ball just shy of warning track in the fifth.

Toronto had scored 46 runs over six games, including a 7-0 win in the series opener Thursday night, but has been held to two total runs since. There were three shutouts in the four-game series.

``This was a well pitched series all around,' Blue Jays manager John Farrell said. ``To think three shutouts were thrown. This is not an easy ballpark to score in.'

Bautista also hit a ninth-inning triple after center fielder Crisp lost the ball in the sun.

Moscoso pitched well enough to win had he received any support. He has been the starter in two of Oakland's three 1-0 losses this season.

``That's the thing about this game. He pitches that good and comes away with a loss,' Oakland catcher Kurt Suzuki said. ``You can't really explain it but it's tough.'

NOTES: The season series wound up 5-5. The A's haven't won the season matchup with Toronto since 2007. ... A's RHP reliever Michael Wuertz threw a 20-pitch bullpen session, his first outing off a mound since going on the DL July 30 with right thumb tendinitis. Wuertz will not make the road trip with the team but rather throw another bullpen in the Bay Area before heading out on a rehab assignment. ``It was good just to get back off the mound,' said Wuertz, who hopes to be activated when the team returns from a 10-game East Coast trek. ``Sept. 2, that's a good target date.' ... After an off day Monday, Brandon McCarthy (6-6) pitches for the A's on Tuesday night at Yankee Stadium looking for a career-best seventh win. He is 5-1 with a 4.10 ERA since the All-Star break.