CINCINNATI (AP) - Bronson Arroyo's unusual season keeps taking strange turns.

Arroyo gave up three more homers, the first by Grady Sizemore, and the Cleveland Indians remained perfect against their intrastate rival, beating Cincinnati 8-2 on Friday night.

Cleveland is 4-0 against Cincinnati, which has struggled mightily against the American League. The defending NL Central champs are 5-11 in interleague play and have lost their season series to Cleveland for the first time since 2005.

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``We took the series, and hopefully we can take a few more games,' Indians starter Justin Masterson said.

Arroyo (7-7) can't keep the ball from landing in the stands lately. He gave up four homers - tying his career high - in a 10-5 victory in Baltimore on Saturday.

The Indians kept the trend going. Arroyo has allowed 24 homers this season, the most in the NL.

``There are so many variables in this game, but it's definitely been a strange year in terms of going out and having consistent stuff,' said Arroyo, who came down with mononucleosis during spring training.

Masterson (6-6) went eight innings for his first win since April 26. He allowed four hits, including the first of Brandon Phillips' two solo homers.

Sizemore hit his first homer since June 8 to start the early Indians rally. Asdrubal Cabrera and Carlos Santana also connected, giving Masterson room to maneuver. Cleveland had scored only 22 runs in his last 11 starts, getting shut out four times.

The Indians swept Cincinnati in Cleveland from May 20-22, when they were at the peak of their startlingly strong start. That sweep pushed their AL Central lead to a season-high seven games. It's been a struggle since.

Following their 30-15 start, the Indians dropped 22 of their next 34, a swoon that knocked them out of first place.

The Reds? They have stagnated within a few games of .500 since that sweep in Cleveland, unable to put together a winning streak or measure up against the AL.

They got manhandled again.

Sizemore's eighth homer got the Indians going in the second inning. He later added an RBI double off Arroyo, who gave up eight runs in 4 2-3 innings.

``It's been a strange year for me as far as feeling up and down on the mound,' Arroyo said.

Arroyo seemed to have an advantage going in: Shin-Soo Choo was out of Cleveland's lineup with a broken left thumb. Choo hit four homers off Arroyo last season - the most by any batter off the same pitcher in the majors.

And, with no designated hitter available, the Indians' lineup also was missing Travis Hafner.

No matter. The Indians pounced on his misplaced pitches just the same.

Sizemore hit a down-the-middle, two-strike pitch for a solo homer. Cabrera added a two-run shot in the third, and Santana homered two pitches later for a 4-0 lead.

By contrast, Masterson has been adept at keeping the ball down and in the park. Phillips led off the fourth with only the fourth homer allowed by the right-hander this season - the first by a right-handed batter. It ended his streak of 36 1-3 innings without giving up a homer.

Phillips, who was traded to the Reds from the Indians in 2006, hit a solo homer in the ninth off Chad Durbin for his 1,000th career hit.

``That's crazy, isn't it? Doing it against the Indians?' Philips said. ``Things happen. I'm happy I got it. I didn't know it before the game, but people kept talking about it, so I looked it up, and I thought, 'Dang.' I'm glad I got it done.'

Notes: The Reds had their eighth sellout of the season. ... Cleveland leads the intrastate series 38-35. ... The Indians are 10-6 in interleague play. ... Indians closer Chris Perez went on the bereavement list to attend his grandmother's funeral in Florida. He's expected back on Sunday. ... Cleveland called up RHP Josh Judy from Triple-A Columbus. ... RF Travis Buck left with a tight left hamstring after running out his two-run single in the fifth. ... Masterson singled in his first at-bat, his second career hit. ... It was Phillips' seventh career multihomer game.