SAN DIEGO (AP) - With the last-place San Diego Padres playing for the future, their biggest news came off the field on Monday night.

The Padres agreed to terms with three of their top six draft picks shortly before the deadline. On the field, the Padres lost 5-4 in 10 innings to the New York Mets as former teammate Scott Hairston drove in the go-ahead run with a fielder's choice and Jason Isringhausen notched his 300th save.

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The Padres agreed to terms with right-hander Joe Ross, the second of their two first-round draft picks, as well as right-hander Michael Kelly and catcher Austin Hedges. Hedges agreed to a $3 million signing bonus, while Ross agreed to $2.75 million and Kelly, $718,000.

The Mets won for just the fourth time in 15 games. Lucas Duda and Josh Thole each had a homer among their three hits, and Thole had three RBIs.

After letting the Padres tie the game in the eighth, the Mets opened the 10th with consecutive walks by Jason Pridie and Thole against rookie left-hander Josh Spence (0-2). They advanced on a sacrifice bunt by Ruben Tejada off Chad Qualls. Pridie scored when Hairston hit a hard grounder to shortstop Alberto Gonzalez with the infield drawn in. Gonzalez fielded the ball and fell backward. He had no play at first but the Padres threw out Thole at third.

Manny Acosta (1-0) got the win after pitching the ninth. Isringhausen allowed a walk and a single in the 10th before securing his seventh save in 11 chances this season and the 300th of his career.

The Padres tied it 4-4 in the bottom of the eighth when Orlando Hudson walked with one out, stole second and scored on pinch-hitter Jesus Guzman's single to right.

Mets starter R.A. Dickey, who had lost his previous three starts, took a no-decision. He was chased by Will Venable's two-run homer in the seventh that pulled the Padres to 4-3. The Mets scored as many runs for Dickey on Monday night as they had in his previous three starts.

``We love the way we fought back, down 4-1,' Padres manager Bud Black said. ``Dickey was baffling us at times. We had some chances and we couldn't break through.'

Dickey allowed three runs on seven hits in 6 1-3 innings, struck out four and walked one.

San Diego starter Aaron Harang left in the sixth inning after a comebacker by Thole hit him on the right wrist or hand. Even so, Harang had thrown 93 pitches and reliever Erik Hamren was already warming up in the bullpen.

Harang went five-plus innings, allowing four runs and eight hits while striking out four and walking three.

``I thought his stuff was fine,' Black said. ``Probably the difference is four to six inches above the knees where they hit some balls. Aaron is good at the top of the zone and the bottom of the zone. What we have seen in the last couple of outings is too many pitches in between that.'

Thole had a two-run homer and Duda a solo shot that gave the Mets a 3-0 lead off Harang in the second. Duda opened the inning with a shot deep into the seats in right field, his fifth. After Pridie walked with one out, Thole reached the home run porch down the right field line, his fourth.

Thole added an RBI single in the fourth to make it 4-1, and singled again in the sixth.

San Diego's Kyle Blanks hit an RBI double in the third. Venable chased Dickey with his two-run homer in the seventh, his fourth. Logan Forsythe was aboard on a leadoff double.

NOTES: It was New York's third win at Petco Park in 13 games. ... Jonathan Niese (11-9, 4.03 ERA) starts for the Mets on Tuesday night. ... Niese lost 3-2 against San Diego at Citi Field on Thursday. ... The Padres counter with Cory Luebke (4-6, 3.09) in a matchup of lefties. ... Luebke has gone with 3-4 with a 2.98 ERA with 56 strikeouts against 11 walks in nine starts since joining the rotation. ... The Mets signed their first-round pick, OF Brandon Nimmo of Cheyenne (Wyo.) East High.