CHICAGO (AP) - Hector Santiago thought he had strike three. Home plate umpire Lance Barrett thought differently.

From there, everything went wrong for the Chicago White Sox.

Matt Wieters homered twice, including a 10th-inning grand slam, lifting the Baltimore Orioles to a come-from-behind 10-4 win over Chicago on Monday night.

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The White Sox took a 4-1 lead into the eighth, but Baltimore hit three solo homers against a pair of relievers to send the game into extra innings.

Chicago reliever Zach Stewart (0-1) allowed six runs in the 10th, five unearned.

Leading off the ninth, Nolan Reimold took a close 2-2 pitch from White Sox closer Santiago that was called a ball by Barrett. Reimold launched the next pitch into the left field seats to cut the White Sox lead to 4-3.

``I kind of walked off (the mound). I don't walk off unless I think it's a strike,' Santiago said. ``That one pitch maybe could have changed the inning, but it's just part of the game because it happens.'

Santiago recovered to retire the next two batters, but then elevated a 2-1 pitch to Adam Jones, who tied the game with his third homer in four days.

It was the first blown save for the rookie closer, who had converted his first three opportunities.

``The way I look at it is how he bounces back,' first-year White Sox manager Robin Ventura said. ``I have confidence in him to take him out there and let him do it again tomorrow night.'

In the 10th, Mark Reynolds skied a ball to the wall off Stewart that center fielder Alejandro De Aza dropped for a three-base error. Chris Davis doubled off the left-field wall to score the go-ahead run.

That opened the door for the Orioles. Reimold added an RBI single and with two outs, Wieters hit his first career grand slam into the right-field seats for his fourth homer of the season.

``We've been battling every game pretty close,' Wieters said. ``It's nice to have a big inning to kind of put some things together.'

Wieters also went deep off Jesse Crain in the eighth to make it 4-2.

Pedro Strop (1-1) picked up the win in relief.

A.J. Pierzynski had three hits for Chicago, including a homer down the right-field line against starter Jake Arrieta. He's 4 for 5 against Arrieta in his career.

Paul Konerko laced a two-run double in the sixth inning, breaking open a tie game and scoring De Aza and Brent Morel. Konerko has hit safely in all nine games this season.

Chicago starter Phil Humber made his season debut and worked out of three jams during his 5 1-3 innings. He was left with a no-decision after throwing 115 pitches, allowing one run, six hits and three walks while striking out seven.

``That's not the way you draw it up, definitely not the way I want to pitch every time I go out there,' said Humber, who hadn't pitched since April 4. ``I didn't have command of my fastball after the second inning. Just had to go to my breaking ball a lot and I was able to make some pitches when I needed to.'

Arrieta (1-1) was effective during his 6 2-3 innings, but his defense committed three errors behind him. Arrieta allowed four runs - two earned - and struck out seven.

Wieters committed a pair of throwing errors as the Orioles surrendered a pair of unearned runs.

The White Sox have split their first four games at U.S. Cellular Field this season after finishing with the American League's second-worst home record last year at 36-45.

NOTES: White Sox pitching coach Don Cooper was ejected in the ninth after Santiago walked Wieters on four pitches. . Left-hander John Danks (1-1, 5.40 ERA) pitches Tuesday for the White Sox against Taiwanese rookie Wei-Yin Chen (0-0, 3.18) in the second game of a four-game set.