WASHINGTON (AP) - Stephen Strasburg struggled with various issues during Washington's 6-1 loss to the San Diego Padres on Tuesday. Some were obvious, others less so.

There was the leadoff double that fell in with three defensive players nearby, starting San Diego's three-run first inning. The 8-minute rain delay in that inning while the bases were loaded and Strasburg faced a 3-2 count. The soggy ball and rosin bag.

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And then there also happened to be a not-quite-clear matter involving what Nationals manager Davey Johnson said was some Hot Stuff penetrating ointment that accidentally ``got to the wrong place.'

``It was on his shoulder and evidently - I don't know how it got to where it got, but it was uncomfortable, to say the least,' Johnson said with a chuckle.

Asked about it, Strasburg said: ``I'm going to keep that in the clubhouse.'

And the other problems?

``As far as the rain, it's tough with them calling it when the count's 3-2 with the bases loaded,' Strasburg said. ``Obviously you've got to throw a fastball over the plate. I got a groundball, it just made it through the hole.'

Stepping back into the batter's box after the brief shower to face Strasburg in the top of the first, San Diego's John Baker guessed what was coming.

Fastball.

Baker smacked the first pitch after play resumed back up the middle for a two-run single, part of his three-hit, three-RBI afternoon, Will Venable produced four hits, and San Diego knocked Strasburg out after only four innings Tuesday, matching the second-shortest appearance of his 25-start career.

``One of the things I respect the most about Strasburg is that he pitches you like a man. He comes at you with the fastball. It's kind of old school,' Baker said. ``You've got to be ready to hit that - and if you're not ready, then he's going to bury you.'

San Diego right-hander Anthony Bass (2-4) - making his 10th start in the majors - tied his longest outing by going eight innings. He allowed five hits and one run - on Bryce Harper's homer to right-center, the 19-year-old outfielder's second consecutive game with a solo shot.

``It's a big thing, going deep into ballgames,' Bass said. ``That's one thing I take a lot of pride in.'

Bass struck out seven and walked one before giving way to reliever Andrew Cashner for the ninth. Cashner struck out Harper swinging at a 101 mph pitch to end it.

Nationals second baseman Danny Espinosa, who went 0 for 3, said it's rarely easy facing a pitcher for the first time.

``Until you get up there and get an idea of what kind of life he has on his fastball, and what his changeup and slider are like, you don't have a true sense of how you need to react to the pitch,' Espinosa said. ``He had everything going today.'

Venable led off the game with a seemingly harmless blooper off Strasburg that dropped in for a double as left fielder Roger Bernadina, center fielder Rick Ankiel and shortstop Ian Desmond watched it fall.

``I should have caught that ball,' Bernadina said.

Said Padres manager Bud Black: ``That was a break, no doubt about it, and we took advantage of it. ... That got the Nationals on their heels a little bit, and we drove Strasburg's pitch count up.'

After a walk, Yonder Alonso hit an RBI single, and then Baker's single made it 3-0.

All told, it was a slog of an opening inning for Strasburg, who needed 39 pitches to get three outs. Including the rain delay and a visit from pitching coach Steve McCatty, that half-inning alone lasted about 25 minutes from start to finish.

James Darnell's first homer of the season, a solo shot in the third, made it 4-0, and Strasburg only stuck around for one more inning.

Strasburg gave up four runs and seven hits, leaving after 81 pitches, 55 for strikes. He walked two batters and struck out five, and his ERA rose from 1.64 to 2.25.

When he was coming back late last season from reconstructive elbow surgery, Strasburg lasted only three innings on Sept. 11, in his second appearance of 2011, and then went four innings on Sept. 23. The right-hander had gone at least six innings in all previous seven starts this season.

``Sometimes it's just not going to be your day and things aren't going to go your way,' Strasburg said. ``Bloop hits fell for them. Hard shots didn't fall for us.'

NOTES: Baker's third hit was a double awarded in the eighth when the ball girl down the right-field line moved over and tried to glove the baseball. For the record: She missed it. ... Venable hit two singles, a double and a triple. ... San Diego lost four of its past five games, and Washington won four of five.