Denver Broncos defensive end Derek Wolfe was carted off the field during Saturday's practice after suffering a right ankle injury.
"It's an ankle injury. We're not sure how bad," coach Vance Joseph said. "We're kind of assuming it's not that bad."
Wolfe's injury came on the heels of the team placing fellow defensive end Billy Winn on injured reserve. Winn sustained a torn ACL in Thursday's preseason game against the Chicago Bears.
Wolfe, 27, was injured when he became tangled up with offensive tackle Menelik Watson in a team drill. Trainers helped Wolfe onto a cart and he was taken to the locker room. He also was sent for an MRI exam following practice.
Wolfe, like most starters, played very little in the Broncos' 24-17 victory at Soldier Field on Thursday night.
Wolfe recorded 51 tackles and 5.5 sacks in 14 games last season. Since being drafted in the second round in 2012, he owns 191 tackles and 22.5 sacks in 69 games (all starts).
Winn collected 19 tackles and one fumble recovery in 16 games, including two starts, last season for the Broncos.
The 28-year-old Winn has recorded 111 tackles, three sacks, two interceptions and two forced fumbles in 68 career games since being selected in the sixth round of the 2012 draft by the Cleveland Browns.