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Last Updated Oct 20, 2021, 11:00 AM

Houston Astros vs. Boston Red Sox Predictions, Odds, Preview

October 20, 2021
Jonathan Willis
MLB Expert

Game 45of the ALCS is set for Wednesday night as the Houston Astros take on the Boston Red Sox. First pitch is set for 5:08 p.m. ET and will air on FS1 from Fenway Park in Boston, Massachusetts.

Houston Astros vs. Boston Red Sox Game 5 Predictions

The ALCS is now guaranteed to return to Houston after the Astros overcame a late 2-1 deficit to beat the Boston Red Sox 9-2 in Fenway Park in Game 4 on Tuesday night.

Umpire Laz Diaz somewhat overshadowed the proceedings with one of the worst games you will see behind the plate. A missed strike three call helped spark a seven-run ninth inning for the Astros to even the series, and Diaz ended up missing almost two dozen pitches on the evening.

Boston is favored to shake off that tough loss in Game 5 on Wednesday afternoon, as the Red Sox rocked Framber Valdez in Game 1 last Friday.

Score Prediction

Red Sox 5, Astros 3

The Red Sox were due for a bad offensive outing, but Boston will do enough at the plate to take a 3-2 series lead heading back to the Lone Star State this weekend.

Best Bets

Under 9.5

Red Sox (-120)

Houston Astros vs. Boston Red Sox Game 5 Betting Odds

Game odds provided by DraftKings - subject to change

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