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Last Updated Dec 22, 2021, 15:00 PM

San Francisco 49ers vs. Tennessee Titans Predictions, Odds, Picks

Dec. 23, 2021
Michael Crosson
VI Betting Expert
VegasInsider.com

The 16th week of regular-season NFL action will kick things off on Thursday night with a compelling non-conference matchup between the San Francisco 49ers and Tennessee Titans. Coverage begins from Nissan Stadium at 8:20 p.m. ET on NFL Network.

Score Prediction

Niners 31, Titans 20

Best Bets

Niners -3 (-120) at Treasure Island

San Francisco 49ers vs. Tennessee Titans Predictions

After finishing last in the NFC West with a record of 6-10 last year, San Francisco kept that same ball rolling with another slow start to this season, as the Niners opened with a lackluster 3-5 SU and 2-6 ATS skid – with their SU victories coming against a relatively unimpressive group of opponents in the Lions, Bears, and Eagles.

The 49ers have completely flipped the script since Week 9 though, considering San Francisco enters Thursday’s contest boasting wins in five of the last six games – with three of those victories coming by 20 PTS or more.

On the other hand, Tennessee looked like legitimate Super Bowl contenders through the first half of the season, as the Titans kicked things off with an impressive 8-2 SU and 7-3 ATS run – despite being favored in just five of those affairs.

The absence of All-Pro RB Derrick Henry has inevitably caught up with the Titans over the last few weeks though, considering Tennessee enters Thursday’s contest following losses in three of the last five games – while averaging just 16.4 PPG on 324 YPG across that span.

I’ll lay the points with San Francisco here, as the Niners are 5-1 SU and ATS across the last six games, driven by their offense scoring 29.2 PPG and their defense allowing 18.7 PPG across that same stretch – while the Titans’ offense has averaged just 18.3 PPG on 302.3 YPG since Henry’s injury in Week 8.

San Francisco 49ers vs. Tennessee Titans Betting Odds

More Odds | Futures Odds




The Titans enter Thursday’s contest as a 3.5-point underdog against the visiting 49ers, which marks the sixth straight game San Francisco has been favored in.

The total for Thursday’s affair is currently stationed just south of OU 45 at most shops – marking the lowest over-under set for a Niners’ game since visiting the Bears in Week 8 (O 40.5).

San Francisco 49ers vs. Tennessee Titans Betting Resources

  • Matchup: NFC West vs. AFC South
  • Date: Thursday, December 23, 2021
  • Venue: Nissan Stadium
  • Location: Nashville, Tennessee
  • TV-Time: NFLN - 8:20 p.m. ET

San Francisco 49ers Betting Analysis

Straight Up - SU, Against the Spread - ATS, Over-Under (O/U)

  • SU: 8-6
  • ATS: 7-7
  • O/U: 7-6-1
  • ATS - Away: 4-3

After falling a field goal shy of posting three straight wins to open the season (L, 30-28), San Francisco drew another tough matchup against the Seahawks in Week 4 – and that’s when things noticeably took a downward turn, as QB Jimmy Garoppolo exited with a calf injury and turned over the keys to rookie Trey Lance for the remainder of the Niners’ second straight loss.

The Niners’ offensive struggles persisted a few weeks further, as they averaged just 19.5 PPG across a 1-3 SU and ATS stretch across Weeks 5 through 9. San Francisco has completely turned things around since Week 9 though, considering the Niners are 5-1 SU and ATS across the last six games – while scoring 30+ PTS in all but one of those victories (29.2 PPG).

Tennessee Titans Betting Analysis

Straight Up - SU, Against the Spread - ATS, Over-Under (O/U)

  • SU: 9-5
  • ATS: 8-6
  • O/U: 7-7
  • ATS - Home: 2-5

After winning the AFC South with a record of 11-5 last year, Tennessee appeared to have its sights set on a much bigger goal to start this season, as the Titans opened with wins in eight of their first ten games – which included impressive upset victories over the Bills, Chiefs, Seahawks, Colts, and Rams.

Tennessee lacks an offensive identity with Henry sidelined though, considering the Titans have averaged just 14.8 PPG on 324 YPG across the last four games, inevitably resulting in losses to the Texans, Patriots, and Steelers – and an ugly win over the Jaguars (W, 20-0).

Inside the Stats - San Francisco 49ers

  • Record: 8-6
  • Division Standing: 3rd - NFC West
  • Points Scored: 360
  • Points Allowed: 314
  • PS/G: 25.7 (13th)
  • PA/G: 22.4 (18th)

Inside the Stats - Tennessee Titans

  • Record: 9-5
  • Division Standing: 1st - AFC South
  • Points Scored: 337
  • Points Allowed: 309
  • PS/G: 24.1 (15th)
  • PA/G: 22.1 (14th)

Key Players to Watch

  • SFO: Nick Bosa - DE (14 GS, 15 SK, 18 TFL)
  • SFO: Deebo Samuel - WR (1,088 REC YDS, 269 RSH YDS, 12 TD)
  • TEN: Ryan Tannehill - QB (66.2% CMP, 3,118 YDS, 14 TD, 14 INT)
  • TEN: D'Onta Foreman - RB (Wk. 15 @ PIT - 22 CAR, 2 REC, 135 TOT YDS)

San Francisco 49ers vs. Tennessee Titans Betting Conclusion

After posting losses in three of the last four games, the Titans will enter this Thursday’s contest as 3.5-point underdogs against the visiting Niners – marking the first time Tennessee has been a home underdog since hosting the Chiefs in Week 7.

I’ll lay the points with San Francisco here, as the Niners have been phenomenal on both sides of the ball since mid-November, averaging 29.2 PPG on offense and surrendering just 18.7 PPG across the last six games – while the Titans have scored 20 PTS or less in four straight games (14.8 PPG, 338 YPG).

San Francisco 49ers vs. Tennessee Titans Betting Trends

  • The Niners are 5-1 ATS in their last six games.
  • The Titans are 1-4 ATS in their last five games.
  • The Niners are 8-3 SU in their last 11 games against Tennessee.
  • The total has gone UNDER in four of the last six Titans' games.


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