Last Updated Nov 13, 2022, 12:45 PM

Minnesota Vikings vs. Buffalo Bills Picks, Predictions, Odds

Week 10 of the NFL season will resume on Sunday afternoon with a heavyweight non-conference battle between the Minnesota Vikings and Buffalo Bills. Coverage begins from Highmark Stadium in Orchard Park at 1:00 p.m. ET on FOX.


We’re past the halfway mark of the 2022 NFL season, and it looks like the Bills have slowly become the new Chiefs, except with a much better defense, which is a scary thought. However, like the Chiefs, this high-powered Buffalo squad has also become prone to head-scratching offensive lapses, as the Bills scored just 18 PPG on 407 YPG in frustrating division losses to the Dolphins and Jets, opposed to racking up 30.7 PPG on 420 YPG across their six victories.

The Vikings, on the other hand, have very quietly strung together the second-best record in the league through the first half of the season, as Minnesota currently boasts a comfortable 3.5-game lead over Green Bay and Chicago in the NFC North standings with a record of 7-1, and their only loss came on the road in Philly against the undefeated Eagles.

However, I’ll back Buffalo to cover here, as the Bills’ defense has been an absolute terror the last two seasons, highlighted by their top-ranked scoring defensive unit from last year holding its opponents to 21 PTS or less in eight straight contests to open this season (14.8 PPG). And I think we’ll see the Bills move the ball with relative ease against a Minnesota defense that’s allowed 22+ PTS in five-of-eight contests so far this year (20.1 PPG).

Score Prediction: Bills 28, Vikings 20
Best Bet: Bills -6.5 (-110)


More Odds | Super Bowl Odds | Expert Picks


Date: Sunday, November 13, 2022
Matchup: NFC North vs. AFC East
Venue: Highmark Stadium
Location: Orchard Park, New York
Time-TV: FOX, 1:00 p.m. ET


The Vikings are off to a surprisingly dominant start to the season, as Minnesota racked up 24.1 PPG and allowed just 20.1 PPG across a red-hot 7-1 run to kick off the year, which ranks eighth and 12th in the league respectively.

Minnesota hasn’t exactly faced the most impressive group of opponents, as the Vikings’ wins thus far have come against the Packers, Lions, Saints, Bears, Cardinals, Commanders, and Dolphins (without Tua).

However, to give credit where credit is due, these are all professionals, and posting a 7-1 record in the NFL certainly isn’t an easy feat under any circumstance. I just don’t think Kirk Cousins and co. stack up against two-way juggernauts like Buffalo, but that’s also the case for most squads in the league.

This image has an empty alt attribute; its file name is MRyan-Wk6.webp
The Vikings are 2-4 ATS in their last six matchups against Buffalo. (Getty)


The Eagles may currently own the best record in the league at 8-0, however, I can assure you, this Buffalo squad fears absolutely nobody, as the Bills’ defense picked up right where it left off last year by allowing 21 PTS or less in eight straight contests to open the season (13.5 PPG), which is an overwhelming amount of support for an offense that ranks third in scoring at an average of 27.5 PPG.

The Bills still have their flaws. They’re currently juggling a handful of health issues, and their rushing attack in virtually nonexistent outside of the quarterback position. Regardless of how you spin it, though, Buffalo still strikes me as one of the most dangerous teams in football, even if Allen isn’t at full strength.


  • The total has gone OVER in 11 of Minnesota's last 16 games.
  • The Vikings are 6-0 SU in their last six games.
  • The Vikings are 2-4 ATS in their last six games against Buffalo.
  • The total has gone UNDER in six straight Bills' games.
  • The Bills are 4-1 SU in their last five games.
  • The Bills are 7-0 SU in their last seven home games.
  • The Vikings are 1-4 SU in their last five games against Buffalo.
  • The total has gone UNDER in four of Minnesota's last six road games.
  • The total has gone UNDER in four of Minnesota's last five road games against Buffalo.
We may be compensated by the company links provided on this page. Read more

NFL News