Last Updated Jan 29, 2023, 3:19 PM

San Francisco 49ers vs. Philadelphia Eagles Picks, Predictions, Odds

The Conference Round of the NFL Playoffs kicks things off on Sunday afternoon with a heavyweight NFC showdown between the San Francisco 49ers and Philadelphia Eagles. Coverage begins from Lincoln Financial Field in South Philly at 3:00 p.m. ET on FOX.


The Eagles and Niners share several similarities, but none more so than the fact that the overall merit of both of their journeys have been consistently belittled throughout the year due to a weak strength of schedule, and rightfully so, as Philly’s slate of opponents yielded a record of 134-149-6 during the regular season, and San Francisco’s went 120-168-1.

It’s no secret that the Niners were playing their best football heading into the Divisional Round. They’ve looked utterly unstoppable since the transition from Jimmy Garoppolo to Brock Purdy back in Week 13, highlighted by the Niners racking up a lofty average of 30.4 PPG across their last eight contests, while posting a perfect 8-0 record during that stretch.

However, the Niners have one of the best rushing attacks in the league, and prior to their latest affair, Purdy and co. drew an easy string matchups against Tampa, Seattle Washington, Vegas, Arizona, and Seattle (again). So, in the Divisional Round against Dallas, San Francisco finally got a chance to pick on someone their own size with Purdy at the helm.

And truth be told, the Niners’ offense looked pretty bad in last week’s matchup. There’s no such thing as an ugly postseason win, though, especially when you’ve got a rookie quarterback steering the ship in a playoff matchup against a high-caliber squad like the Cowboys.

While on the other hand, the strength of schedule debate appears to be far more prevalent in conversations surrounding the Eagles at the moment. Which is fair to an extent, the entire NFC East drew matchups against the NFC North and AFC South this season, and that nearly paved the way for all four teams in the division to reach the postseason.

However, with the way things unfolded, the NFC West actually turned out to be the luckiest of the bunch by drawing matchups against the NFC South and AFC West, which was a cool cakewalk for San Francisco aside from a visit from the Chiefs early in the year.

The Cowboys’ defensive front is the only legit pass rush Purdy has faced since taking the reins, and in last week’s contest, he threw for just 214 yards on 7.4 yards per attempt and posted a QBR of 87.4, easily marking his worst performance as the Niners’ starter, and things certainly won’t get any easier in a matchup against an Eagles’ defense that led the league in sacks by a comfortable margin with 70 on the season. So, I’ll take Philly in this one.

Score Prediction: Eagles 27, Niners 20
Best Bet: Eagles -2.5 (-110)

Take Philly!


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Date: Sunday, January 29, 2023
Matchup: NFC West vs. NFC East
Venue: Lincoln Financial Field
Location: Philadelphia, Pennsylvania
TV-Time: FOX, 3:00 p.m. ET


San Francisco’s offense has absolutely dominated since handing the keys to Purdy back in Week 13. The Niners are now 8-0 in their last eight games, and they’ve racked up a lofty average of 32.6 PPG on the offensive side of the ball during that stretch, which has been more than enough to keep their top-ranked defensive unit afloat.

However, for the longest time, San Francisco’s bread and butter was phenomenal defensive play, and that remained true early in the season. The Niners’ averaged just 22.6 PPG across a solid 7-4 run to open, but ultimately, they were carried by their defense holding their opponents to less than 16 PPG across that span.

The tables have been turned down the stretch, though. By no means has the Niners’ defense performed poorly as of late, however, they’ve been far from perfect, highlighted by their defensive unit allowing 23+ points in two of their last four outings. 

So, after seeing the Niners generate just 19 points on 312 total yards against Dallas in the Divisional Round, I think it’s safe to say that San Francisco’s defense is going to have to play much better in order to get past the Eagles in Philly this Sunday.

The Eagles are 8-2 ATS in their last 10 matchups against San Francisco.


Thanks to the entire NFC East’s weak strength of schedule, the Eagles have pretty much cruised all the way to the Conference Championship Game unhindered, considering they’ve matched up with just two teams all year that finished with 10+ regular season wins, the Vikings and the Cowboys.

So, regarding title contention, the Eagles still haven’t encountered a true test yet, and they certainly weren’t tested in the Divisional Round either, highlighted by the Birds running away with a 38-7 victory over the Giants in their first playoff matchup, marking the second occasion in which they beat New York by 25+ points this year.

The question remains, though, will the Birds finally break a sweat in the Conference Round? Unfortunately, I think we’re looking at another mismatch in favor of Philly. In Purdy’s first outing against a legit pass rush, San Francisco simply couldn’t move the ball, and to a similar extent, he’ll probably struggle against Philly’s top-ranked defensive front as well.

And in a matchup against an Eagles team that’s scored 35+ points in four of their last six contests started by Jalen Hurts, I highly doubt we’ll see the Niners escape with a victory on the heels of another lackluster performance on the offensive side of the script.


  • The Niners are 9-1 ATS in their last 10 games.
  • The total has gone OVER in four of San Francisco's last five games.
  • The Niners are 10-0 SU in their last 10 games.
  • The Eagles are 1-4 ATS in their last five games.
  • The total has gone UNDER in four of Philadelphia's last five games.
  • The Eagles are 15-3 SU in their last 18 games.
  • The Eagles are 8-2 SU in their last 10 home games.
  • The Niners are 2-8 ATS in their last 10 games against Philadelphia.
  • The Niners are 3-7 SU in their last 10 games against Philadelphia.
  • The Niners are 5-1 SU in their last 6 road games.
  • The total has gone UNDER in four of Philadelphia's last five matchups against San Francisco.
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