NFL Odds Week 16: Saints vs Rams Lines, Spreads, Betting Trends

Patrick Everson Sports Betting Expert

3 minute read

Week 16 of the NFL season kicks things off with Thursday Night Football between the New Orleans Saints and Los Angeles Rams. The betting odds see Los Angeles as a four-point favorite despite both teams owning the same record and coming off a win in their latest affair. Coverage begins from SoFi Stadium in Inglewood, California on Thursday, December 21 at 8:15 p.m. ET on Amazon Prime Video.

Here's everything you need to know about the NFL odds for Week 16: Saints vs. Rams lines, spreads, betting trends and more.

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New Orleans Saints vs Los Angeles Rams Odds

• Opening point spread: Rams -3.5
• Opening moneyline: Rams -210/Saints +175
• Opening total: Over/Under 44.5 points scored
• Time: 8:15 p.m. ET Thursday (Prime)

UPDATE 5:30 P.M. ET THURSDAY: With kickoff under four hours away, the Rams are 4-point favorites at Fanatics/PointsBet. On Sunday night, L.A. opened -3.5, and the line peaked -4.5 before dipping to -4.

Spread tickets are running 3/1 and spread money just short of 2/1 on the host Rams. The money count represents a notable shift from early this afternoon, when it was 3/1-plus on Los Angeles.

The total moved from 45 to 46 and back to 45 over the course of the week. Ticket count is 2/1 and money almost 4/1 on the Over. Three hours ago, money was 2/1 on the Under.

In player props tonight, the most tickets are on Rams running back Kyren Williams Anytime Touchdown. He's the -170 favorite, and he's taking the most money in the Anytime TD market.

UPDATE 7 P.M. ET WEDNESDAY: TwinSpires Sportsbook opened L.A. as 4.5-point chalk and is at -4 a day out from this game. The Rams are taking 70% of early spread tickets/56% of early spread money.

"Sharp play on the Saints +4.5," TwinSpires director of retail sports Zachary Lucas said, before moving on to the total. "Lopsided liability on the Over."

The total is up 2 points from 44 to 46 at TwinSpires. The Over is getting 63% of tickets/76% of cash.

UPDATE 10 P.M. ET SUNDAY: Los Angeles (7-7 SU/8-5-1 ATS) is on upswings of 4-1 SU/4-0 ATS. In Week 15, the Rams built a 20-0 lead by early in the third quarter vs. Washington, then let off the gas in a 28-20 win giving 6.5 points at home.

New Orleans (7-7 SU/4-9-1 ATS) is on a modest 2-0 SU and ATS upswing. And that's all it takes to make a charge in the NFC South. In Week 15, the Saints dumped the Giants 24-6 laying 6 points at home.

The SuperBook opened Saints-Rams at L.A. -3.5 tonight and quickly moved to -4. The total is stable at 44.5.

"The Saints just don't play a particularly inspiring brand of football on the road. And the Rams seem to be playing their best ball of the season right now," SuperBook risk supervisor Chase Michaelson said. "I don't anticipate a huge handle here, to be honest. But I'm sure we'll be rooting for New Orleans."

Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 16 Report containing spreads, lines, and trends for every NFL matchup.

Saints vs Rams Pick, Prediction

Action Network NFL betting expert Brandon Anderson offers this prediction:

Check back soon for picks!

Pick: TBD

For more NFL picks, check out Action Network's NFL Week 16: How to Bet Every Game & Every Team.

The One Stat to Know About Saints vs Rams

Action Network NFL researcher Evan Abrams offers his top betting stat:

Check back soon for betting stats!

For more NFL betting stats, check out Action Network's NFL Week 16 Betting Trends, Stats, Notes.

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Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson