WASHINGTON (AP) - One out away from completing a dominating victory, disaster struck for the Seattle Mariners.

Wilson Ramos capped Washington's five-run ninth inning with a game-ending three-run homer, lifting the Nationals to a dramatic 6-5 victory over the Mariners on Tuesday night.

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``Obviously, things turned in a hurry,' Seattle manager Eric Wedge said.

The Mariners wasted a fine effort from Doug Fister, who allowed one run and three hits in eight innings. The right-hander is 0-3 in four June starts despite a 3.60 ERA.

Brandon League replaced Fister for the ninth and Jayson Werth reached on a two-base error by first baseman Justin Smoak to begin the inning. Roger Bernadina walked before Ryan Zimmerman hit into a double play, leaving Werth on third.

Jerry Hairston followed with a run-scoring single and Michael Morse reached on a comebacker that hit League in the right calf, forcing him out of the game after attempting several warmup pitches.

``He couldn't feel much down there, and that was his push-off leg, so we had to get him out of there,' Wedge said.

David Pauley (4-1) entered and gave up an RBI single to Danny Espinosa, setting the stage for Ramos.

``Everything was kind of a messed-up situation, but it's no excuse,' Pauley said. ``You have to go out there and make pitches, and I made a bad one.'

Adam Kennedy had three hits and two RBIs for Seattle, which finished with 13 hits. Prized prospect Dustin Ackley also drove in two runs.

``We just strung together some hits. We didn't kill the ball,' Kennedy said. ``It was just good situational hitting and we kept the pressure on them. It would have been nice to get a couple of more, obviously, with the way it turned out.'

Four of Seattle's first five batters singled, giving the Mariners a 2-0 lead. Kennedy and Ackley each had run-scoring hits.

The Mariners also scored in the third, fourth and fifth. Ackley drove in a run with a fielder's choice in the third and Fister had an RBI single in the fourth for his first major league hit. Kennedy singled in Brendan Ryan, making it 5-0 and chasing Nationals starter Livan Hernandez.

Fister cruised through much of the game. He retired 10 straight after Werth's leadoff single in the first. An infield hit by Zimmerman ended the run, but Fister set down the next five batters before Washington got its first real offensive chance.

Fister hit Ian Desmond and walked Werth with one out in the sixth, and Bernadina singled in Desmond. Fister quickly ended the jam with a double-play ball from Zimmerman, and the Nationals did not have another baserunner until the ninth inning.

Wedge said it was an easy decision to remove his starter on a hot, humid night even though Fister had thrown just 99 pitches.

``We even debated sending him back out for the eighth inning because it was so hot and he had been on base a couple of times,' Wedge said. ``He had worked so hard, and so that was enough for him today. We felt like we pushed him through the eighth inning. League hadn't pitched in three days and he needed to pitch. He's been our guy, but it didn't work out.'

NOTES: Fister took some solace in the defeat in getting his first hit and RBI. ``Putting the helmet on, I felt like a little kid out there,' he said. ... Mariners CF Franklin Gutierrez equaled a season high with three hits. ... The Mariners made their first visit to D.C. since 2005 and their first-ever visit to Nationals Park.