OAKLAND, Calif. (AP) - Luke Gregerson bounced a pitch in front of San Diego catcher John Baker, costing the Padres a one-run lead. It turned out to be the least of his troubles.

Three pitches later, Gregerson gave up a two-run home run to Oakland pinch-hitter Jonny Gomes that provided the difference in San Diego's 6-4 loss to the Athletics on Saturday.

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Now after winning three straight games in Seattle to begin the week, the Padres are on the verge of getting swept themselves.

``It's been like that all year,' first baseman Yonder Alonso said. ``There's no quitting in us. We're going to keep fighting but it's definitely something I've never gone through. It's been a learning experience.'

Carlos Quentin hit a home run and Will Venable also drove in two runs for San Diego, which came back from a three-run deficit in the fifth and briefly led before dropping their second straight in this interleague series with Oakland.

On Friday, the Padres gave up five runs in the first inning and trailed the rest of the way. A day later, they had a late lead before the bullpen let it slip away.

A's shortstop Cliff Pennington, who had reached base in his last seven at_bats before fouling out in the eighth, walked to open the seventh. One out later he went to second on Weeks' single and to third on Josh Reddick's fielder's choice.

Gregerson replaced Joe Thatcher one pitch into Gomes' at-bat and immediately bounced a pitch that allowed Pennington to score the tying run. Gomes then hit Gregerson's 3-1 delivery into the left field bleachers.

Gregerson had allowed only one run over his previous seven outings until Gomes ended his 0-for-34 slump as a pinch-hitter.

``Luke's been good on righties,' Black said. ``It just didn't happen today. He fell behind and it hurt him.'

Seth Smith also homered for the A's, who have won a season-high five straight. Jemile Weeks and Collin Cowgill drove in runs.

Sean Doolittle (1-0) pitched the seventh and earned his first major league victory.

Padres starter Ross Ohlendorf lasted 4 2-3 innings in his first start of the season, allowing three runs on five hits. He walked two and struck out three.

A's starter Tyson Ross, in his first big league start in nearly three weeks, took a no-hitter into the sixth inning before giving up a two-run, two-out home run to Quentin.

Ross allowed the two runs on one hit over his six innings. He walked four and struck out six in his first major league start since May 30.

Ohlendorf didn't allow a hit in the first three innings. Smith's seventh home run of the season cleared the center field wall with one out. Brandon Moss doubled and Cowgill singled later in the inning to put the A's ahead 2-0.

``They took advantage of some balls out over the plate but overall (Ohlendorf) hung in there,' Black said. ``They nicked him for a few runs but overall there was more good than bad.'

Weeks made it 3-0 with an RBI double in the fifth.

Quentin's home run, his sixth of the season, brought the Padres within one in the sixth. Quentin was hit by a pitch for the 102nd time in his career in the second inning.

Venable's two-run double against Doolitte in the seventh put San Diego ahead 4-3.

NOTES: Ohlendorf is the 12th starting pitcher used by the Padres. ... Padres' RHP Micah Owings (strained right forearm) was scratched from his first rehab start Friday night. ... The A's send RHP Bartolo Colon (6-6, 4.21) to the mound in Sunday's series finale. He's 1-1 in two career starts against the Padres, though he hasn't faced them in six years. ... LHP Clayton Richards (3-7, 4.30) goes for the Padres on Sunday. He's 2-2 over his last four starts following a five-game losing streak. ... Pennington has drawn a walk in three consecutive games for the first time this season. ... Padres' OF Mark Kotsay extended his hitting streak against the A's to 13 games.