CHICAGO (AP) - Doug Davis made his 300th career start in the major leagues Friday afternoon at Wrigley Field. It certainly won't make his memory book.

The Cubs' southpaw struggled mightily, throwing 111 pitches in just 4 2-3 innings with six walks and one hit batter. The Pirates went on to win 4-2.

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``I'm not going to make any excuses for walking six people. That's for sure,' Davis said. ``I've been around long enough to know that walking that many guys against any team is going to come back to haunt you.'

Davis allowed only two earned runs on four hits, but his wildness got the best of him.

Pittsburgh led 2-0 after scoring two unearned runs on two Cubs errors in the second, when things fell apart for Davis in the fourth. He walked three batters, including Andrew McCutchen to force in a run with the bases loaded. Davis added a hit batter for good measure.

Davis, who is 0-3 on the season with a 6.75 ERA, hasn't won a start since May 5, 2010.

He missed the last 4 1/2 months in 2010 due to an inflammation of lining around the heart and left elbow tendonitis. He signed a minor league contract with the Cubs on April 11 and was promoted from Triple-A Iowa on May 16.

``Having a year off and everything else, I certainly didn't expect he was going to be a guy that was going come in here ultra sharp, give us seven, eight innings,' manager Mike Quade said.

The Cubs had their chances to get back into the game.

Trailing 4-0, they had the bases loaded and two outs in the eighth, but Aramis Ramirez popped out to second. Alfonso Soriano put the Cubs on the board with a two-run homer in the ninth. Carlos Pena was 2 for 3 with a walk.

The Cubs bullpen pitched 4 1-3 innings, allowing no runs on three hits.

Kevin Correia (7-4) limited Chicago to four singles and a pair of walks in 7 1-3 innings. He moved into a tie with Boston's Jon Lester for the major league lead in wins, and has six of the Pirates' 14 victories away from PNC Park this season.

``You throw half your games on the road your whole career, so it really doesn't effect me at all,' Correia said. ``Every place is a little different.'

NOTES: The Cubs activated Rodrigo Lopez, acquired from Atlanta in a minor-league trade on Thursday. He was 6-1 this season for Triple-A Gwinnett. To make room on the 40-man roster, the Cubs designated Coello for assignment. Justin Berg, who threw 12 straight balls to the three batters he faced in his last outing, was optioned to Triple-A Iowa. ... Carlos Zambrano said the stiff neck he had checked out after Thursday's win over the Mets is getting better. He thinks the problem started because of the way he positions his head on the pillow while he watches TV at home. ... Hurdle said 3B Pedro Alvarez will be able hit while he rehabs from a right quad strain. Alvarez won't be allowed to run the bases or play in the field. ... The game-time temperature at Wrigley Field was 48 degrees, the fourth straight game on the Cubs' current home stand that it's been below 50 degrees. It's been below 50 in 15 of their first 25 home games.