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Featured Last Updated Oct 22 2025, 10:47 AM

Cleveland Cavaliers vs. New York Knicks: Prediction, Odds, Best Bet

Derek Mountain
Derek Mountain Sports Betting Expert
7 minute read
Cleveland Cavaliers vs. New York Knicks: Prediction, Odds, Best Bet

Image Credit: Patrick Gorski via Imagn Images

CLE @ NYK Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Cleveland Cavaliers 505 Cavaliers
+4 -110 -1.5 -110 + -1.5 -110 + -1.5 -110 + -1.5 -110 + -1.5 -110 + N/A -1.5 -110 + -1.5 -115 -1.5 -108 + -3.5 -105  
New York Knicks 506 Knicks
-4 -110 +1.5 -110 + +1.5 -110 + +1.5 -110 + +1.5 -110 + +1.5 -120 + N/A +1.5 -110 + +1.5 -115 +1.5 -121 + +3.5 -115  
Cleveland Cavaliers 505 Cavaliers
o227.5 -110 o110.5 -110 + N/A o110.5 -110 + o110.5 -110 + o110.5 -110 + o110 -110 + o110.5 -110 + o110.5 -115 o110.5 -112 + o226.5 -115  
New York Knicks 506 Knicks
u227.5 -110 u110.5 -110 + N/A u110.5 -110 + u110.5 -110 + u110.5 -120 + u110 -110 + u110.5 -110 + u110.5 -115 u110.5 -120 + u226.5 -105  
Cleveland Cavaliers 505 Cavaliers
+150 -135 + -145 + -135 + -135 + -145 + -148 + N/A -140 -141 + -162  
New York Knicks 506 Knicks
-180 +115 + +120 + +114 + +115 + +115 + +118 + N/A +105 +112 + +136  
Cleveland Cavaliers 505 Cavaliers
+4 -110 -1 -110 + -0.5 -118 + -0.5 -118 + -1 -120 + -0.5 -125 + -0.5 -122 + -0.5 -120 + -0.5 -120 -0.5 -118 + -3.5 -105  
New York Knicks 506 Knicks
-4 -110 +1 -110 + +0.5 -102 + +0.5 -102 + +1 -120 + +0.5 -105 + +0.5 -104 + +0.5 -105 + +0.5 -110 +0.5 -110 + +3.5 -115  
Cleveland Cavaliers 505 Cavaliers
o227.5 -110 o55.5 -105 + N/A o55.5 -112 + o55.5 -120 + o55.5 -105 + o55.5 -106 + o55.5 -105 + o55.5 -115 o55.5 -112 + o226.5 -115  
New York Knicks 506 Knicks
u227.5 -110 u55.5 -115 + N/A u55.5 -108 + u55.5 -120 + u55.5 -115 + u55.5 -120 + u55.5 -120 + u55.5 -115 u55.5 -120 + u226.5 -105  
Cleveland Cavaliers 505 Cavaliers
+150 -130 + -135 + -130 + -140 + -135 + -138 + N/A -140 -134 + -162  
New York Knicks 506 Knicks
-180 +110 + +110 + +110 + +110 + +105 + +112 + N/A +105 +105 + +136  
Cleveland Cavaliers 505 Cavaliers
+4 -110 N/A N/A -1.5 -105 + -1.5 -115 + N/A N/A N/A N/A -1.5 -108 + -3.5 -105  
New York Knicks 506 Knicks
-4 -110 N/A N/A +1.5 -115 + +1.5 -125 + N/A N/A N/A N/A +1.5 -124 + +3.5 -115  
Cleveland Cavaliers 505 Cavaliers
o227.5 -110 N/A N/A o116.5 -115 + o116.5 -115 + N/A N/A N/A N/A o115.5 -117 + o226.5 -115  
New York Knicks 506 Knicks
u227.5 -110 N/A N/A u116.5 -115 + u116.5 -125 + N/A N/A N/A N/A u115.5 -117 + u226.5 -105  
Cleveland Cavaliers 505 Cavaliers
+150 N/A N/A -140 + N/A N/A -134 + N/A N/A -134 + -162  
New York Knicks 506 Knicks
-180 N/A N/A +110 + N/A N/A +114 + N/A N/A +106 + +136  
Cleveland Cavaliers 505 Cavaliers
+4 -110 -0.5 -120 + N/A -0.5 -112 + -1.5 even + N/A -0.5 -125 + -0.5 -120 + -0.5 -115 -1.5 +105 + -3.5 -105  
New York Knicks 506 Knicks
-4 -110 +0.5 -110 + N/A +0.5 -108 + +1.5 -140 + N/A +0.5 -102 + +0.5 -110 + +0.5 -115 +1.5 -139 + +3.5 -115  
Cleveland Cavaliers 505 Cavaliers
o227.5 -110 o55 -115 + N/A o54.5 -120 + o55.5 -115 + N/A o54.5 -120 + o55.5 -105 + o55.5 -110 o54.5 -122 + o226.5 -115  
New York Knicks 506 Knicks
u227.5 -110 u55 -115 + N/A u54.5 -110 + u55.5 -125 + N/A u54.5 -106 + u55.5 -125 + u55.5 -120 u54.5 -110 + u226.5 -105  
Cleveland Cavaliers 505 Cavaliers
+150 -130 + N/A -130 + N/A N/A -134 + N/A -120 -130 + -162  
New York Knicks 506 Knicks
-180 even + N/A even + N/A N/A +108 + N/A -110 +102 + +136  
Cleveland Cavaliers 505 Cavaliers
+4 -110 -1 -115 + N/A -0.5 -105 + -1.5 -110 + N/A -0.5 -120 + -0.5 -120 + -0.5 -115 -1.5 +107 + -3.5 -105  
New York Knicks 506 Knicks
-4 -110 +1 -115 + N/A +0.5 -115 + +1.5 -130 + N/A +0.5 -106 + +0.5 -110 + +0.5 -115 +1.5 -143 + +3.5 -115  
Cleveland Cavaliers 505 Cavaliers
o227.5 -110 o58.5 -115 + N/A o60.5 -110 + N/A N/A o59.5 -122 + o59.5 -110 + o59.5 -105 o59.5 -117 + o226.5 -115  
New York Knicks 506 Knicks
u227.5 -110 u58.5 -115 + N/A u60.5 -120 + N/A N/A u59.5 -104 + u59.5 -125 + u59.5 -125 u59.5 -117 + u226.5 -105  
Cleveland Cavaliers 505 Cavaliers
+150 -140 + N/A -120 + N/A N/A -130 + N/A -125 -122 + -162  
New York Knicks 506 Knicks
-180 +110 + N/A -110 + N/A N/A +104 + N/A -105 -104 + +136  
Cleveland Cavaliers 505 Cavaliers
+4 -110 -0.5 -110 + N/A -1.5 -102 + -1.5 even + N/A -0.5 -113 + -0.5 -110 + -0.5 -115 -1.5 +102 + -3.5 -105  
New York Knicks 506 Knicks
-4 -110 +0.5 -120 + N/A +1.5 -118 + +1.5 -140 + N/A +0.5 -113 + +0.5 -120 + +0.5 -115 +1.5 -134 + +3.5 -115  
Cleveland Cavaliers 505 Cavaliers
o227.5 -110 o57.5 -115 + N/A o55.5 -125 + N/A N/A o56.5 -122 + o56.5 -115 o56.5 -110 o55.5 -127 + o226.5 -115  
New York Knicks 506 Knicks
u227.5 -110 u57.5 -115 + N/A u55.5 -105 + N/A N/A u56.5 -104 + u56.5 -115 u56.5 -120 u55.5 -108 + u226.5 -105  
Cleveland Cavaliers 505 Cavaliers
+150 -120 + N/A -145 + N/A N/A -130 + N/A -125 -132 + -162  
New York Knicks 506 Knicks
-180 -110 + N/A +114 + N/A N/A +106 + N/A -105 +104 + +136  

The Cleveland Cavaliers (0-0) and New York Knicks (0-0) will face off in the NBA tonight. Tipoff is set for 7:00 p.m. EDT from Madison Square Garden in New York, N.Y. The game will broadcast live on ESPN.

The Cavaliers are favored by -1.5 on the spread, with the over/under set at 228.5 total points. The Knicks are +105 favorites to win outright on the moneyline, while the Knicks are +120 to pull off the upset.

Be sure to check out the latest NBA odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 10/22/25

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Cleveland Cavaliers vs. New York Knicks Best Bet

For Donovan Mitchell, 25.5 points is just too low. No Darius Garland, no Max Strus, and De'Andre Hunter is day-to-day.

Mitchell went over this in three of five without Garland last regular season. Since joining Cleveland, he's averaging 29.6 points in 33 games without Garland, according to StatMuse.

Mitchell is also kind of a Knick killer. Since coming to Cleveland, he's over 25.5 points in 6-of-9 in the regular season, 8-of-14 when adding the 2023 playoffs.

Cavaliers vs. Knicks Best Bet: Mitchell Over 25.5 Points (-120) | Mitchell 30+ Points (+165)

(Pick from Bryan Fonseca)

Looking for more best bets? Check out our free NBA picks and our premium subscription for the best picks!

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Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
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