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Last Updated Aug 30, 2021, 9:44 AM

2021 MLB All-Star Game Picks, Predictions, Odds

July 13, 2021
Stuart Durst
VI Betting Expert
VegasInsider.com

After missing last year’s All-Star game due to the COVID-19 pandemic baseball fans across the world are ecstatic for its return at Coors Field this year as the American League and National League will meet in the 2021 MLB All-Star Game.

The action from Denver, Colorado is expected to begin at 7:30 p.m. ET with FOX providing national coverage.

All-Star Game Betting Predictions & Picks

Score Prediction

  • American League 9 National League 6

Best Bets

  • American League (-105)
  • Over 11 (-105)
  • American League -1.5 (+170)
  • American League by 3 runs (+1200)

Odds per BetMGM - Subject to Change

While a game like the All-Star game isn't easy to handicap I will be personally siding with the American League at slightly better odds. I would say the main advantage the National League has coming into this matchup is their incredibly impressive pitching staff.

Coors Field is historically known as a hitters ballpark and I think the fact that this game is being played in Colorado does give a slight advantage to the American League. The AL is known for their incredibly high-powered offenses and I think we see that take over on Tuesday.

It’s very easy, and lazy, to argue that the National League is “due” but considering the fact that this is two different rosters competing with each other every year I don’t think that logically follows. The National League just lost one of their best players, Ronald Acuna Jr., to a season-ending injury meaning we will see some last-minute unexpected changes to the starting lineup.

Overall it’s a bit of a tossup considering just how talented both teams are but I like the better odds any day. I’m excited to see if the American League can carry over some of that regular-season power and give the fans a nice high-scoring affair.

All-Star Game Betting Odds

  • National League -115
  • American League -105
  • Over 11 (-105)
  • Under 11 (-115)
  • National League -1.5 (+125)
  • American League +1.5 (-155)

Odds per BetMGM - Subject to Change

On BetMGM, the National League is currently the favorite (-115), with the American League listed at -105 as the underdog. While there has been a myriad of injuries none have affected the game more than Ronald Acuna Jr. going down with a torn ACL just days before the All-Star game was set to start.

If you’re familiar with how the All-Star game has gone over the last couple of years then you may be incredibly surprised to see the National League as the slight favorites. The American League has currently won seven straight All-Star games along with 25 of the last 32 competitions. Despite any talent disparity, there may be on a year-to-year basis the American League clearly has the National Leagues number in this game.

2021 MLB All-Star Game Betting Resources

  • Location: Denver, Colorado
  • Venue: Coors Field
  • TV-Time: FOX - 7:30 p.m. (ET)
  • AL Manager: Kevin Cash (Tampa Bay)
  • NL Manager: Dave Roberts (L.A. Dodgers)


2021 American League All-Star Starters

C - Salvador Perez (Kansas City), 7th ASG
1B - Vladimir Guerrero, Jr. (Toronto), 1st ASG
2B - Marcus Semien (Toronto), 1st ASG
3B - Rafael Devers (Boston), 1st ASG
SS - Xander Bogaerts (Boston), 3rd ASG
OF - Mike Trout, Inj. (Los Angeles), 9th ASG
OF - Aaron Judge (New York), 3rd ASG
OF - Teoscar Hernandez (Toronto), 1st ASG
DH - Shohei Ohtani (Los Angeles), 1st ASG

2021 National League All-Star Starters

C - Buster Posey, Inj. (San Francisco), 7th ASG
1B - Freddie Freeman (Atlanta), 5th ASG
2B - Adam Frazier (Pittsburgh), 1st ASG
3B - Nolan Arenado (St. Louis), 6th ASG
SS - Fernando Tatis, Jr. (San Diego), 1st ASG
OF - Ronald Acuna, Jr., Inj. (Atlanta), 2nd ASG
OF - Nick Castellanos (Cincinnati), 1st ASG
OF - Jesse Winker (Cincinnati), 1st ASG

Whether it be injury or rest there have been multiple changes to the roster over the last couple of days including Manny Machado and Omar Narvaez being added just yesterday. Before that, the announced replacements were Tim Anderson, Chris Bassitt, Whit Merrifield and, Joey Wendle in the American League and Walker Buehler, Justin Turner, Max Scherzer, Taijuan Walker, and Freddy Peralta.

The Dodgers, Brewers, and Padres were the most represented teams this year each having five representatives. After that the Blue Jays, Astros, Nationals, and White Sox all have four players representing them. Teams with only one All-Star representative this year are the Diamondbacks, Rockies, Marlins, Mariners, Twins, Tigers, and Orioles. While some of these struggling teams due appear to be underrepresented it will be interesting to see how they perform among the nation’s best players.

2021 American League All-Star Reserves

C - Mike Zunino (Tampa Bay) - 1st ASG
1B - Matt Olson (Oakland) - 1st ASG
1B - Jared Walsh (Los Angeles) - 1st ASG
2B - Jose Altuve (Houston) - 7th ASG
2B - Whit Merrifield (Kansas City) - 2nd ASG
3B - Jose Ramirez (Cleveland) - 3rd ASG
3B - Joey Wendle (Tampa Bay) - 1st ASG
SS - Bo Bichette (Toronto) - 1st ASG
SS - Tim Anderson (Chicago) - 1st ASG
SS - Carlos Correa (Houston) - 2nd ASG
OF - Michael Brantley (Houston) - 5th ASG
OF - Joey Gallo (Texas) - 2nd ASG
OF - Adolis Garcia (Texas- 1st ASG
OF - Cedric Mullins (Baltimore) - 1st ASG
DH - Nelson Cruz (Minnesota) - 7th ASG
DH - J.D. Martinez (Boston) - 4th ASG

2021 National League All-Star Reserves

C - Yadier Molina (St. Louis) - 10 ASG
C - Omar Narvaez (Milwaukee) - 1st ASG
C - J.T. Realmuto (Philadelphia) - 3rd ASG
1B - Max Muncy (Los Angeles) - 2nd ASG
2B - Ozzie Albies (Atlanta) - 2nd ASG
2B - Jake Cronenworth (San Diego) - 1st ASG
3B - Kris Bryant (Chicago) - 4th ASG
3B - Eduardo Escobar (Arizona) - 1st ASG
3B - Manny Machado (San Diego) - 5th ASG
3B - Justin Turner (Los Angeles) - 2nd ASG
SS - Brandon Crawford (San Francisco) - 3rd ASG
SS - Trea Troner (Washington) - 1st ASG
OF - Mookie Betts (Los Angeles) - 5th ASG
OF - Kyle Schwarber (Washington) - 1st ASG
OF - Chris Taylor (Los Angeles) - 1st ASG
OF - Juan Soto (Washington) - 1st ASG
OF - Bryan Reynolds (Pittsburgh) - 1st ASG


AL Cy Young Award favorite Gerrit Cole heads to his fourth All-Star Game with a solid 2021 performance with the Yankees. (AP)

2021 American League All-Star Pitchers

Matt Barnes (Boston) - 1st ASG
Chris Bassitt (Oakland) - 1st ASG
Shane Bieber (Cleveland) - 2nd ASG
Aroldis Chapman (New York) - 7th ASG
Gerrit Cole (New York) - 4th ASG
Nathan Eovaldi (Boston) - 1st ASG
Kyle Gibson (Texas) - 1st ASG
Lance Lynn (Chicago) - 2nd ASG
Liam Hendriks (Chicago) - 2nd ASG
Yusei Kikuchi (Seattle) - 1st ASG
Shohei Ohtani (Los Angeles) - 1st ASG
Carlos Rodon (Chicago) - 1st ASG
Ryan Pressly (Houston) - 2nd ASG
Gregory Soto (Detroit) - 1st ASG

2021 National League All-Star Pitchers

Walker Buehler (Los Angeles) - 2nd ASG
Josh Hader (Milwaukee) - 3rd ASG
Jacob deGrom (New York) - 4th ASG
Kevin Gausman (San Francisco) - 1st ASG
Corbin Burnes (Milwaukee) - 1st ASG
Yu Darvish (San Diego) - 5th ASG
Brandon Woodruff (Milwaukee) - 2nd ASG
Trevor Rogers (Miami) - 1st ASG
Taijuan Walker (New York) - 1st ASG
Zack Wheeler (Philadelphia) - 1st ASG
Craig Kimbrel (Chicago) - 8th ASG
Mark Melancon (San Diego) - 4th ASG
Alex Reyes (St. Louis) - 1st ASG
Max Scherzer (Washington) - 8th ASG
Freddy Peralta (Milwaukee) - 1st ASG
German Marquez (Colorado) - 1st ASG

MLB All-Star Game History (Last 10)

  • 2019 - Progressive Field, Cleveland (American League, 4-3)
  • 2018 - Nationals Park, Washington (American League, 8-6)
  • 2017 - Marlins Park, Miami (American League, 2-1)
  • 2016 - Petco Park, San Diego (American League, 4-2)
  • 2015 - Great American Ballpark, Cincinnati (American League, 6-3)
  • 2014 - Target Field, Minnesota (American League, 5-3)
  • 2013 - Citi Field, New York (American League, 3-0)
  • 2012 - Kauffman Stadium, Kansas City (National League, 8-0)
  • 2011 - Chase Field, Phoenix (National League, 5-1)
  • 2010 - Angel Stadium, Anaheim (National League, 3-1)
  • 2009 - Busch Stadium, St. Louis (American League, 4-3)


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