NFL Odds Week 10: 49ers vs Jaguars Lines, Spreads, Betting Trends

Matchup Spread Total Moneyline
Jaguars vs
+3 (-105)
-3 (-115)
o44.5 (-112)
u44.5 (-108)

Week 10 of the NFL season continues with a marquee non-conference matchup between the 49ers and Jaguars. The betting odds see San Francisco as a three-point road favorite despite riding a three game losing streak. Coverage begins from EverBank Stadium in Jacksonville on Sunday, November 12 at 1:00 p.m. ET on FOX.

Here's everything you need to know about the NFL odds for Week 10 49ers vs. Jaguars: the opening lines, spreads, betting trends and more. Stay tuned for more details regarding our ESPN BET promo code as we prepare for the upcoming launch!

San Francisco 49ers vs Jacksonville Jaguars Odds

Christian Kirk and the Jaguars are riding a five-game win streak. (Getty)
  • Opening point spread: 49ers -3 (even)
  • Opening moneyline: 49ers -160/Jaguars +140
  • Opening total: Over/Under 44.5 points scored
  • Time: 1 p.m. ET Sunday (FOX)

UPDATE 10:30 A.M. ET SUNDAY: The Niners hit BetMGM's NFL odds Week 10 market at -3 (-105) last Sunday and dipped to -2.5 (-115) Monday. Within a couple hours, San Fran was at -3 flat, and on Friday, the line moved to -3 (-115).

The 49ers are taking 59% of spread tickets/68% of spread money. On the moneyline, the lean is toward the underdog Jaguars (+145). Jacksonville is drawing 67% of tickets/57% of money.

"The public is on the chalk this week, backing San Francisco and Baltimore," BetMGM trader Seamus Magee said. "We’ll need the Jaguars and the Browns to cover in these highly anticipated matchups."

The total opened at 44.5, peaked at 46 Tuesday and has been at 45 since Wednesday afternoon. The Under is getting 57% of tickets/64% of money.

UPDATE 4:30 P.M. ET WEDNESDAY: San Francisco hasn't moved off -3 yet in TwinSpires' NFL odds Week 10 market. The Jaguars are netting 54% of early spread bets, while 55% of early spread cash is on the Niners.

"Great two-way action so far this week. It'll likely close 49ers -3/-2.5," Lucas said.

The total nudged from 44.5 to 45, with 62% of tickets/55% of money on the Over.

UPDATE 11:30 P.M. ET SUNDAY: This is arguably the best matchup in the NFL odds Week 9 market, and both teams should be fresh, coming off their bye weeks.

Jacksonville (6-2 SU and ATS) is on a five-game SU and ATS spree. In Week 8, the Jags dispatched Pittsburgh 20-10 as 2.5-point road favorites.

San Francisco (5-3 SU/4-4 ATS) raced out to a 5-0 SU/4-1 ATS start, but surprisingly hit the skids in Weeks 6-8. The Niners tumbled to Cincinnati 31-17 laying 4.5 points at home in Week 8, their third consecutive SU and ATS setback.

"Both teams were on byes, so not a ton changed from the lookahead, which we closed at San Francisco -2.5 (-120). Which is frankly a pretty similar line to -3 (even)," Michaelson said. "The whole West Coast team going east thing that the wiseguys like is probably negated a little bit by the bye week. And though San Francisco has struggled recently, the 49ers are still power-rated like few others."

Neither the spread nor total moved tonight at The SuperBook.

Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 10 Report containing spreads, lines, and trends for every NFL matchup.

49ers vs. Jaguars Pick, Prediction

Action Network NFL betting expert Brandon Anderson offers this prediction:

Check back soon for picks!

Pick: TBD

For more NFL picks, check out Action Network's NFL Week 10: How to Bet Every Game & Every Team.

The One Stat to Know About 49ers vs. Jaguars

Action Network NFL researcher Evan Abrams offers his top betting stat:

When two teams are off 14-plus days rest – a bye – last 20 years, the favorite is 31-22 SU, but with no home/road advantage, 19-19 split.

For more NFL betting stats, check out Action Network's NFL Week 10 Betting Trends, Stats, Notes.

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