NFL Odds Week 10: Colts vs Patriots Lines, Spreads, Betting Trends

Matchup Spread Total Moneyline
Patriots vs
Colts
+1.5 (-110)
-1.5 (-110)
o42.5 (-105)
u42.5 (-115)
-100
-118

Week 10 of the NFL season showcases another matchup from Germany as the Colts battle the struggling Patriots. The betting line sees Indianapolis as a 1.5-point favorite over New England. Coverage begins from Deutsche Bank Park in Frankfurt on Sunday, November 12 at 9:30 a.m. ET on NFL Network.

Here's everything you need to know about the NFL odds for Week 10 Colts vs. Patriots: the opening lines, spreads, betting trends and more. Stay tuned for more details regarding our ESPN BET promo code as we prepare for the upcoming launch!

Indianapolis Colts vs New England Patriots Odds

The Colts look to reach .500 with a win against the Patriots. (Getty)
  • Opening point spread: Pick
  • Opening moneyline: Colts TBA/Patriots TBA
  • Opening total: Over/Under 43.5 points scored
  • Time: 9:30 a.m. ET Sunday (NFL Network)

UPDATE 6 P.M. ET FRIDAY: In the final Europe game of the season, taking place in Frankfurt, Germany, the Colts are -1.5 (-115) at BetMGM. The Colts opened -1.5 Sunday night, went to -2 Monday, then fell back to -1 by Tuesday morning.

Indy rebounded to -1.5 Tuesday afternoon and hit the current -1.5 (-115) Thursday afternoon. Spread ticket count is 3/1 and money nearing 2.5/1 on the Colts.

The total went from 43.5 to 43 Thursday, with the Under getting pounded to the tune of 88% of tickets/92% of money. In fact, by ticket count, Colts-Patriots is the most-bet Under in BetMGM's NFL odds Week 10 market.

UPDATE 11:30 P.M. ET SUNDAY: New England's freefall of a season continued in Week 9 at home against Washington. The Patriots (2-7 SU and ATS) were 3-point home favorites and lost outright 20-17.

Indianapolis (4-5 SU/5-4 ATS) ended a three-game SU slide. The Colts dropped the Panthers 27-13 giving 1.5 points on the road.

Colts-Patriots is a neutral-site game, taking place in Frankfurt, Germany. The line has already moved from pick 'em to Colts -1 at The SuperBook.

Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 10 Report containing spreads, lines, and trends for every NFL matchup.

Colts vs Patriots Pick, Prediction

Action Network NFL betting expert Brandon Anderson offers this prediction:

This rivalry ain't what it used to be, but it looks like the Colts have finally found a path forward to the future, which is more than we can say for Bill Belichick and the Patriots at this point.

Shane Steichen has done a great job, even with injuries and a lack of high-end personnel, and the Colts rank 12th in both Offensive and Defensive DVOA. The offense in particular is a real strength compared to New England. The offensive line has become a strength under Steichen and a faltering Patriots defense is beatable. New England's line has fallen apart and ranks last in Pass Block Win Rate, so the Colts can win this game in the trenches.

It's typically profitable betting favorites in international games. Excluding Jaguars games, international favorites are 23-9 ATS (72%), including 12-3 ATS as favorites of a field goal or less.

Pick: Colts -1.5 (-115)

For more NFL picks, check out Action Network's NFL Week 10: How to Bet Every Game & Every Team.

The One Stat to Know About Colts vs Patriots

Action Network NFL researcher Evan Abrams offers his top betting stat:

The Colts are the only NFL team to score 20 points in every game this season. They’ve scored 20-plus in 10 straight games. The second-longest streak? Jaguars and Browns with five games.

For more NFL betting stats, check out Action Network's NFL Week 10 Betting Trends, Stats, Notes.

Where to place a bet this NFL Season?

  • Use our exclusive BetMGM Bonus Code VIBONUS1500 to unlock BetMGM’s welcome offer for new sportsbook users!
  • Compare the latest NFL Odds from the best sportsbooks before placing a bet on this week's games.
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