NFL Odds Week 10: Giants vs Cowboys Lines, Spreads, Betting Trends

Patrick Everson Sports Betting Expert

4 minute read

Week 10 of the NFL season continues with a matchup between NFL East division rivals as the Giants visit the Cowboys. The betting odds see New York as a massive 16-point underdog following a season-ending injury to QB Daniel Jones. Coverage begins from AT&T Stadium in Arlington, Texas on Sunday, November 12 at 4:25 p.m. ET on FOX.

Here's everything you need to know about the NFL odds for Week 10 Giants vs. Cowboys: the opening lines, spreads, betting trends and more. Stay tuned for more details regarding our ESPN BET promo code as we prepare for the upcoming launch!

New York Giants vs Dallas Cowboys Odds

• Opening point spread: Cowboys -15
• Opening moneyline: Cowboys -1600/Giants +850
• Opening total: Over/Under 40.5 points scored
• Time: 4:25 p.m. ET Sunday (FOX)

UPDATE 4:30 P.M. ET WEDNESDAY: Dallas opened a hefty 16.5-point favorite in TwinSpires' NFL odds Week 10 market and is up a notch to -16.5 against shorthanded New York. Spread tickets and money are running 2/1 on the Cowoboys.

"We need Tommy DeVito to have the game of his life. We aren't hopeful," Lucas said, alluding to the undrafted rookie QB making his first start for the Giants.

The total dipped a point from 39.5 to 38.5, with 53% of tickets/56% of money on the Under so far.

UPDATE 11:30 P.M. ET SUNDAY: Dallas (5-3 SU and ATS) certainly had its chances to knock off defending NFC champion Philadelphia. But the Cowboys came up short 28-23 catching 3 points on the road.

New York (2-7 SU/2-6-1 ATS) had no answer in Las Vegas, falling behind 27-0 by midway through the third quarter in a 30-6 loss getting 1.5 points. QB Daniel Jones exited in the first quarter with what's reported to be a significant knee injury.

That changed the outlook a lot for Giants-Cowboys.

"We closed Cowboys -10 on [last week's] lookahead line, and then Daniel Jones got hurt. So it's Tommy DeVito, who has not looked like an NFL-caliber QB so far," Michaelson said. "Daniel Jones being worth a TD seems crazy, but the market doesn't think highly of DeVito. Plus, the Cowboys are classic flat-track bullies. They blow out bad teams at home.

"The public might be scared off by this line, but we'll see."

Early on, Dallas is already getting attention. The SuperBook moved from -15 to -15.5, then to -16, all within an hour of opening tonight.

Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 10 Report containing spreads, lines, and trends for every NFL matchup.

Giants vs. Cowboys Pick, Prediction

Action Network NFL betting expert Brandon Anderson offers this prediction:

If you're looking for some special matchup or wild insight as to why the Giants might secretly have a chance here, I don't have it. DeVito should be at least a little better with a full week of practice as the starter, but this is as a big a mismatch as we've seen this season and you remember the 40-0 meeting the first time.

There's no reason to expect the Giants to contend — which is why we have to bet them. Brian Daboll is 8-4 ATS after a loss and 5-2 as a division underdog, but the team-agnostic trends really line up here and support double-digit 'dogs on the road and in the division. It's about playing the number, because sports are wild and crazy things happen.

Since 2018, moneyline underdogs at +750 or longer are 4-18 straight up. That might not seem great, but that's good for a 69% ROI. It doesn't have to make sense. Just play the long number.

Pick: Giants ML (+1000)

For more NFL picks, check out Action Network's NFL Week 10: How to Bet Every Game & Every Team.

The One Stat to Know About Giants vs. Cowboys

Action Network NFL researcher Evan Abrams offers his top betting stat:

Dallas: Double-digit favorites in divisional games are 122-149-9 ATS (45%) last 20 years. In November or earlier, they are 54-85-6 ATS (38.8%).

For more NFL betting stats, check out Action Network's NFL Week 10 Betting Trends, Stats, Notes.

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Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson