Arizona Cardinals vs. Seattle Seahawks Picks, Predictions, Odds

Week 6 of the NFL season will resume on Sunday mid-afternoon with a compelling NFC West showdown between the Arizona Cardinals and Seattle Seahawks. Coverage begins from Lumen Field in Seattle at 4:05 p.m. ET on FOX.

Updated on 04/17/2024
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The Cardinals are off to a frustrating 2-3 start to the season, however, cut them some slack, their schedule hasn’t exactly been a walk in the park, as Arizona racked up 27.5 PPG on 376 YPG across a pair of wins over the Raiders and Panthers, and averaged just 16.7 PPG on 337 YPG in losses to the Chiefs, Rams, and Eagles.

The Seahawks, on the other hand, also went 2-3 in their first five contests, however, Seattle has been lauded for its surprisingly pedestrian start, as Geno Smith and co. currently rank seventh in the league in scoring and eighth in total offense at 25.4 PPG and 368 YPG respectively, which nobody saw coming. But it still hasn’t been enough to compensate for their defense surrendering 27+ PTS in four-of-five matchups to open the season (30.8 PPG).

I’ll back Arizona to cover here, as Kyler Murray and co. should rip Seattle’s bottom-ranked defense to shreds in Sunday’s contest (31 PPG, 430 YPG), and while the Seahawks’ offense generated 34.3 PPG on 457 YPG against a trio of soft defenses in Atlanta, Detroit, and New Orleans, they also looked terrible against tough San Francisco and Denver defensive units (12 PPG, 235 YPG). So, I think we’ll see them struggle against a Cardinals defense that’s surrendered 20 PTS or less in three-of-five matchups so far this season.

Score Prediction: Cardinals 28, Seahawks 20
Best Bet: Cardinals -2.5 (-110)


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Date: Sunday, Oct. 16, 2022
Matchup: NFC West
Venue: Lumen Field
Location: Seattle, Washington
Time-TV: FOX, 4:05 p.m. ET


After barreling out to an impressive 10-2 start to the season, the Cardinals completely fell apart down the homestretch last year, as Arizona closed the regular season with a head-scratching 1-4 skid, which included frustrating losses to the Lions, Colts, and Seahawks. Despite their bumpy finish, the Cards still secured the top NFC Wild Card spot with a record of 11-6, however, their struggles only got worse in the postseason, as the Rams stomped them by a score of 34-11 in the opening round.

So, compared to last year’s miserable finish, the Cardinals have looked great to start this season, however, they still scored 17 PTS or less in two of their first five matchups, and that type of offensive inconsistency doesn’t bode well for a squad that also allows 24.6 PPG on the defensive side. But they shouldn’t have trouble moving the ball against a Seahawks defense that surrendered 30.8 PPG on 430 YPG in their first five contests.

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The Cardinals are 6-1 ATS in their last seven road games against Seattle. (Getty Images)


The Seahawks have been one of the most exciting squads to watch through the first five weeks of the season, as Seattle posted a surprisingly modest 2-3 stretch in the immediate aftermath of Russell Wilson’s departure, while scoring 23+ PTS in three of those contests and allowing 27+ PTS in four of them (25 OPPG, 31 DPPG).

However, Seattle’s offensive numbers are heavily inflated by a pair of monster performances in Weeks 4 and 5, highlighted by the Seahawks scored just 15.7 PPG on 296 YPG in their first three matchups of the season, compared to 40 PPG on 476 YPG in their latest two affairs. We shouldn’t focus on the explosiveness of Seattle’s offense, though. We should really be talking about their abomination of a defense that’s allowed 27+ PTS in four-of-five matchups to open the season.


  • The total has gone UNDER in seven of Arizona's last ten games.
  • The total has gone OVER in six of Seattle's last eight games.
  • The total has gone UNDER in four of Seattle's last six games against Arizona.
  • The Cardinals are 3-8 SU in their last 11 games.
  • The total has gone OVER in four of Seattle's last five home games.
  • The Cardinals are 6-3 ATS in their last nine games against Seattle.
  • The Seahawks are 1-6 ATS in their last seven home games against Arizona.
  • The Cardinals are 10-2 ATS in their last 12 road games.
  • The Cardinals are 6-1 ATS in their last seven road games against Seattle.

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  • Use our exclusive BetMGM Bonus Code VIBONUS1500 to unlock BetMGM’s welcome offer for new sportsbook users!
  • Compare the latest NFL Odds from the best sportsbooks before placing a bet on this week's games.
  • Check out the North Carolina Sportsbooks just before they launch legal online sports betting.