Jacksonville Jaguars vs. Indianapolis Colts Picks, Predictions, Odds

Week 6 of the NFL season will resume on Sunday afternoon with a compelling AFC South rematch between the Jacksonville Jaguars and Indianapolis Colts. Coverage begins from Lucas Oil Stadium in Indy at 1:00 p.m. ET on CBS.

Updated on 04/20/2024
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Jacksonville showed flashes of brilliance in their first three contests under new head coach Doug Pederson, as the Jaguars averaged 28 PPG and turned the ball over just once across a solid 2-1 start to open the season. However, Trevor Lawrence and co. have been careless with the ball the last few weeks, as the Jaguars scored just 13.5 PPG and turned the ball over seven times in ugly losses to the Eagles and Texans in Weeks 4 and 5.

The Colts, on the other hand, elected to move in a different direction at QB after missing the playoffs with a record of 9-8 last season, and so far, it’s been an absolute disaster, as Indy’s offense averaged a league-worst 13.8 PPG and turned the ball over 11 times in Matt Ryan’s first five games under center, mostly thanks to Ryan’s seven interceptions and 11 fumbles. (three fumbles lost)

I’ll back Jacksonville here, as this will be the second meeting of the year between these AFC South rivals, as the Jaguars held Indy to 218 total yards and forced three turnovers en route to a triumphant 24-0 home win over the Colts back in Week 2. And while it’s probably not fair to expect another shutout performance from the Jags’ defense this Sunday, the Colts’ have now scored 20 PTS or less in five straight contests to start the season, so I like my chances with a Jags squad that averaged 26.3 PPG across their first four matchups of the season.

Score Prediction: Jaguars 23, Colts 20
Best Bet: Jaguars ML (+115)


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Date: Sunday, Oct. 16, 2022
Matchup: AFC South
Venue: Lucas Oil Stadium
Location: Indianapolis, Indiana
Time-TV: CBS, 1:00 p.m. ET


The Jaguars finished dead last in the AFC South with a record of 3-14 last season, which was the worst mark in the entire league, as the Texans and Jets both narrowly edged Jacksonville by one game at the bottom of the totem pole. However, Jacksonville’s offensive struggles during Lawrence’s rookie campaign were inexcusable, as the Jags’ glorified first overall pick led them to just 14.9 PPG on 305 YPG last season, which ranked 32nd in scoring and 27th in total yardage.

The Jaguars aren’t exactly an AFC powerhouse yet, but at least their offense is playing much better with Pederson at the helm this season (22.2 PPG), and that’s pretty much all the front office can ask for with a 23-year-old QB and a new coach leading the charge.

The Colts are 0-6 ATS in their last six matchups against Jacksonville. (Getty Images)


The Colts’ offense averaged 26.5 PPG and turned the ball over just 19 times with Carson Wentz under center last season, which ranked Top 10 in the league in both departments, as Wentz completed 62% of his passes for 3,563 YDS and a 27-7 INT ratio in his first campaign with Indy. However, the Colts still underachieved as a unit, so they decided to bring in 37-year-old veteran Matt Ryan to help guide the ship, and so far, the move hasn’t worked at all, as the Indy’s offense currently ranks dead-last in scoring (14.3 PPG), and they’ve turned the ball over a league-worst 11 times.

It's easy to look at this Colts squad as a group still ironing out kinks with a new signal-caller under center, however, there’s only so much a team can do when their new QB throws seven picks and fumbles the ball 11 times in the first five games of the season.


  • The Jaguars are 3-10 ATS in their last 13 games.
  • The Colts are 2-5 ATS in their last seven games.
  • The total has gone OVER in six of Jacksonville's last nine games.
  • The total has gone UNDER in 10 straight Colts' games.
  • The Jaguars are 3-11 SU in their last 14 games.
  • Jacksonville are 6-0 ATS in their last six games against Indianapolis.
  • The total has gone UNDER in five of Indianapolis' last six home games.
  • The Jaguars are 4-2 SU in their last six games against Indianapolis.
  • The total has gone OVER in five straight Jaguars' road games.
  • The Jaguars are 1-8 SU in their last nine road games games against Indianapolis.
  • The total has gone UNDER in four of the last five games between the Colts and Jaguars.

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  • Compare the latest NFL Odds from the best sportsbooks before placing a bet on this week's games.
  • Check out the North Carolina Sportsbooks just before they launch legal online sports betting.