Dallas Cowboys vs. San Francisco 49ers Picks, Predictions, Odds

The NFL playoffs continue on Sunday afternoon in the Bay Area with an NFC Divisional Playoff matchup between the Dallas Cowboys and San Francisco 49ers. Coverage begins from Levi's Stadium in Santa Clara at 6:30 p.m. ET on FOX.

Updated on 04/23/2024
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Back in the early 90’s, Cowboys-49ers was must-watch television in the NFC playoffs. Dallas captured the 1992 NFC Championship by knocking off San Francisco at Candlestick Park, followed by a home win over the 49ers the next season. The Cowboys grabbed back-to-back Super Bowl victories those seasons, but Dallas lost the next year to San Francisco, who cruised to a Super Bowl title in 1994.

However, this marks the second consecutive postseason that Dallas and San Francisco are hooking up as the 49ers eliminated the Cowboys at AT&T Stadium in the Wild Card round last season. San Francisco won 23-17, as Dallas’ late rally came up short thanks to Dak Prescott and the Cowboys running out of time on the final possession.

This time around, Dallas is listed as an underdog, marking the second time this season when Prescott is starting that the Cowboys are receiving points (first time came in the Week 1 loss to Tampa Bay). 

The 49ers pulled away from the Seahawks last week, but face a Cowboys’ team that crushed the Buccaneers on Monday night for the franchise’s first road playoff win in 30 years, which came at San Francisco.

Dallas is in a tough scheduling spot by playing its fourth straight road game and owning less rest than San Francisco. However, as long as the Cowboys can avoid a slow start similar to last year’s matchup, they have a good chance not only at a cover, but an outright victory on Sunday.

Score Prediction: Cowboys 24, 49ers 21
Best Bet: Cowboys +3.5 (-110)


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Date: Sunday, January 22, 2023
Matchup: NFC Divisional Playoffs
Venue: Levi's Stadium
Location: Santa Clara, California
Time-TV: FOX, 6:30 p.m. ET



Will this be the season for Prescott and the Cowboys to make their first Super Bowl since 1995? Dallas finished in second place of the NFC East with a 12-5 record, as the Cowboys took care of business as a road favorite in a Wild Card blowout of Tampa Bay, 31-14 as 2 ½-point chalk.

Prescott threw for 305 yards and four touchdowns and Dallas won in spite of kicker Brett Maher missing four extra points, which has not happened since 1932. The Cowboys improved to 5-4 away from AT&T Stadium, with two of those losses coming in overtime at Green Bay and Jacksonville.

In three opportunities as a road underdog this season, Dallas posted a 2-1 ATS mark, but all three games with back-up Cooper Rush running the show in place of the injured Prescott.

Since 2014, the Cowboys own a 3-4 SU and 2-5 ATS mark in the playoffs, while losing six straight times in the divisional round dating back to 1996. The last time Dallas was victorious in the divisional playoffs was the same year they won their most recent Super Bowl in 1995, when the Cowboys defeated the Eagles, 30-11.

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The Cowboys and 49ers meet in the playoffs for a second straight year. (Getty)


The 49ers remain the hottest team in the NFL after picking up their 11th consecutive win by knocking off the Seahawks, 41-23 in the Wild Card round. San Francisco trailed 16-14 at the half, but the Niners scored 25 unanswered points, which included two touchdown passes and a touchdown run by rookie quarterback Brock Purdy.

Purdy threw for 332 yards in his playoff debut, while running back Christian McCaffrey rushed for 119 yards and pulled in a touchdown pass from “Mr. Irrelevant,” the nickname given to the former Iowa State quarterback for being the last pick of the NFL draft.

Purdy has been anything but irrelevant after taking over for Jimmy Garoppolo in a Week 13 win over Miami as the 49ers are a perfect 6-0 in the rookie’s six starts. San Francisco has cashed five times during this stretch with the lone ATS defeat coming as 10-point favorites in an overtime triumph at Las Vegas.

From a totals perspective, the 49ers have eclipsed the total in six of the last seven games, while scoring 30 points or more in four of the past five contests.


  • 49ers are 5-1 to the Over in the last six games
  • 49ers are 6-0 ATS in the last six games
  • Cowboys are 4-1 to the Under in their last five road games
  • Cowboys are 3-1 ATS in the last four games as an underdog

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  • Compare the latest NFL Odds from the best sportsbooks before placing a bet on this week's games.
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