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Featured Last Updated Sep 4 2025, 1:33 PM

49ers vs. Seahawks Week 1 Prediction, Odds, Where to Watch

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
8 minute read
49ers vs. Seahawks Week 1 Prediction, Odds, Where to Watch

San Francisco 49ers vs. Seattle Seahawks Odds, NFL Week 1

Image Credit: Joe Nicholson-Imagn Images

SF @ SEA Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
San Francisco 49ers 473 49ers
-1.5 -108 -0.5 -115 + N/A -0.5 -112 + -0.5 -110 + -0.5 -115 + -1.5 +110 + -0.5 -110 -1.5 +106 + -1.5 +106 -2.5 -112  
Seattle Seahawks 474 Seahawks
+1.5 -112 +0.5 -105 + N/A +0.5 -108 + +0.5 -110 + +0.5 -115 + +1.5 -130 + +0.5 -110 +1.5 -130 + +1.5 -130 +2.5 -108  
San Francisco 49ers 473 49ers
o45.5 -110 N/A N/A N/A N/A N/A N/A o10.5 -105 N/A N/A o43.5 -108  
Seattle Seahawks 474 Seahawks
u45.5 -110 N/A N/A N/A N/A N/A N/A u10.5 -125 N/A N/A u43.5 -112  
San Francisco 49ers 473 49ers
-120 -135 + -130 + -135 + -130 + -135 + -122 + -130 -130 + -130 -142  
Seattle Seahawks 474 Seahawks
even +115 + +110 + +114 + +110 + +105 + -100 + +110 +105 + +105 +120  
San Francisco 49ers 473 49ers
-1.5 -108 -0.5 +130 + -0.5 +130 + -0.5 +130 + -0.5 +130 + -0.5 +125 + -1.5 +140 + -0.5 +120 -1.5 +138 + -1.5 +138 -2.5 -112  
Seattle Seahawks 474 Seahawks
+1.5 -112 +0.5 -155 + +0.5 -165 + +0.5 -155 + +0.5 -160 + +0.5 -160 + +1.5 -170 + +0.5 -160 +1.5 -175 + +1.5 -175 +2.5 -108  
San Francisco 49ers 473 49ers
o45.5 -110 o7.5 -110 + N/A o7.5 -108 + o7.5 -115 + o7.5 even + o7.5 +106 + o8.5 -120 o7.5 +108 + o7.5 +108 o43.5 -108  
Seattle Seahawks 474 Seahawks
u45.5 -110 u7.5 -110 + N/A u7.5 -112 + u7.5 -115 + u7.5 -130 + u7.5 -128 + u8.5 -110 u7.5 -134 + u7.5 -134 u43.5 -112  
San Francisco 49ers 473 49ers
-120 -125 + -120 + -122 + -130 + -125 + -120 + -125 -125 + -125 -142  
Seattle Seahawks 474 Seahawks
even +105 + -102 + +102 + even + -105 + -102 + -105 +102 + +102 +120  
San Francisco 49ers 473 49ers
-1.5 -108 -0.5 -105 + N/A -1.5 +105 + -0.5 -110 + N/A -1.5 +110 + N/A -1.5 +107 + -1.5 +107 -2.5 -112  
Seattle Seahawks 474 Seahawks
+1.5 -112 +0.5 -115 + N/A +1.5 -125 + +0.5 -110 + N/A +1.5 -130 + N/A +1.5 -132 + +1.5 -132 +2.5 -108  
San Francisco 49ers 473 49ers
o45.5 -110 o21.5 -105 + N/A o21.5 -102 + o20.5 -115 + N/A o20.5 -115 + N/A o20.5 -118 + o20.5 -118 o43.5 -108  
Seattle Seahawks 474 Seahawks
u45.5 -110 u21.5 -115 + N/A u21.5 -118 + u20.5 -105 + N/A u20.5 -105 + N/A u20.5 -106 + u20.5 -106 u43.5 -112  
San Francisco 49ers 473 49ers
-120 -120 + N/A -130 + N/A N/A -124 + N/A -129 + -129 -142  
Seattle Seahawks 474 Seahawks
even even + N/A +110 + N/A N/A +106 + N/A +104 + +104 +120  
San Francisco 49ers 473 49ers
-1.5 -108 N/A N/A -0.5 +102 + -1.5 +122 + N/A -1.5 +126 + N/A N/A N/A -2.5 -112  
Seattle Seahawks 474 Seahawks
+1.5 -112 N/A N/A +0.5 -122 + +1.5 -145 + N/A +1.5 -152 + N/A N/A N/A +2.5 -108  
San Francisco 49ers 473 49ers
o45.5 -110 o13.5 +110 + N/A o12.5 -135 + o13.5 even + N/A o13.5 -104 + N/A N/A N/A o43.5 -108  
Seattle Seahawks 474 Seahawks
u45.5 -110 u13.5 -130 + N/A u12.5 +114 + u13.5 -120 + N/A u13.5 -118 + N/A N/A N/A u43.5 -112  
San Francisco 49ers 473 49ers
-120 -135 + N/A -135 + -120 + N/A -118 + N/A N/A N/A -142  
Seattle Seahawks 474 Seahawks
even +115 + N/A +114 + even + N/A -104 + N/A N/A N/A +120  
San Francisco 49ers 473 49ers
-1.5 -108 N/A N/A -0.5 +124 + -1.5 +135 + N/A -1.5 +134 + N/A N/A N/A -2.5 -112  
Seattle Seahawks 474 Seahawks
+1.5 -112 N/A N/A +0.5 -148 + +1.5 -160 + N/A +1.5 -164 + N/A N/A N/A +2.5 -108  
San Francisco 49ers 473 49ers
o45.5 -110 o8.5 -115 + N/A o8.5 -115 + o8.5 -115 + N/A o8.5 -114 + N/A N/A N/A o43.5 -108  
Seattle Seahawks 474 Seahawks
u45.5 -110 u8.5 -105 + N/A u8.5 -105 + u8.5 -105 + N/A u8.5 -108 + N/A N/A N/A u43.5 -112  
San Francisco 49ers 473 49ers
-120 -120 + N/A -120 + -125 + N/A -124 + N/A N/A N/A -142  
Seattle Seahawks 474 Seahawks
even even + N/A even + +105 + N/A +102 + N/A N/A N/A +120  
San Francisco 49ers 473 49ers
-1.5 -108 -0.5 +110 + N/A -0.5 +110 + -1.5 +126 + N/A -1.5 +130 + N/A N/A N/A -2.5 -112  
Seattle Seahawks 474 Seahawks
+1.5 -112 +0.5 -130 + N/A +0.5 -130 + +1.5 -150 + N/A +1.5 -160 + N/A N/A N/A +2.5 -108  
San Francisco 49ers 473 49ers
o45.5 -110 o12.5 -110 + N/A o12.5 -105 + o11.5 -110 + N/A o11.5 -112 + N/A N/A N/A o43.5 -108  
Seattle Seahawks 474 Seahawks
u45.5 -110 u12.5 -110 + N/A u12.5 -115 + u11.5 -110 + N/A u11.5 -108 + N/A N/A N/A u43.5 -112  
San Francisco 49ers 473 49ers
-120 -120 + N/A -125 + -120 + N/A -118 + N/A N/A N/A -142  
Seattle Seahawks 474 Seahawks
even even + N/A +102 + even + N/A -102 + N/A N/A N/A +120  

The 49ers will take on the Seahawks in this week's NFL action. Kickoff is set for 4:05 p.m. EDT at Lumen Field in Seattle, Wash. The game will be broadcast live on FOX. Here's everything you need to know about 49ers vs. Seahawks odds, the latest NFL spreads, NFL over/unders and more.

The 49ers opened as a -2.5 point favorite over Seahawks. The total is set at over/under 43.5 total points scored by both teams combined.

Be sure to check out the latest NFL Odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

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49ers vs. Seahawks Best Bet

The 49ers name holds a bit more weight than their game heading into this season. They finally had to pay the piper with all their young players, mainly QB Brock Purdy. Shelling out the money they did for Purdy, Kittle, and Aiyuk (plus CMC) has left the Niners defense in a much worse spot, and now they are dealing with a litany of injuries on offense. Jauan Jennings wants a new contract and is dealing with a calf injury, and he has no return timeline. Brandon Aiyuk looks unlikely to be ready for the season, and even intriguing backup Jacob Cowing is out with a rough hamstring injury. Seattle has concerns with Sam Darnold at QB, but their defense looks strong, and I think they come away with the win against an ailing Niners squad.

49ers vs. Seahawks Pick: Seattle Seahawks Moneyline (+116)

(Pick via Erik Beimfohr)


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What Time is the San Francisco 49ers vs. Seattle Seahawks Game?

The San Francisco 49ers will take on the Seattle Seahawks at 4:05 ET on Sunday, September 7th.

Where is the San Francisco 49ers vs. Seattle Seahawks Game Being Played?

This game is going to be played at Lumen Field in Seattle. WA.

How Can I Watch the 49ers vs. Seahawks?

You can watch The 49ers vs. The Seahawks on FOX.

Can The Seahawks Beat The 49ers?

The Seahawks can certainly beat the 49ers. Although oddsmakers have 49ers as the favorite, it is slight (just 2.5 points).

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 2 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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