Sign Up Subscribe
Featured Last Updated Sep 12 2025, 12:44 PM

NFL: Bears vs. Lions, Prediction, Odds, Best Bet

Derek Mountain
Derek Mountain Sports Betting Expert
9 minute read
NFL: Bears vs. Lions, Prediction, Odds, Best Bet

Featured Image Credit: Jeff Hanisch via Imagn Images

CHI @ DET Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Chicago Bears 263 Bears
+4.5 -105 +3.5 -105 + +3.5 -110 + +3.5 -112 + +3.5 -105 + +3.5 -110 + +3.5 -110 + +3.5 -110 +3.5 -109 + +3.5 -109 +6.5 -112  
Detroit Lions 264 Lions
-4.5 -115 -3.5 -115 + -3.5 -110 + -3.5 -108 + -3.5 -115 + -3.5 -120 + -3.5 -110 + -3.5 -110 -3.5 -114 + -3.5 -114 -6.5 -108  
Chicago Bears 263 Bears
o48.5 -110 o23.5 -105 + N/A o23.5 -105 + o23.5 -105 + N/A o23.5 -120 + o24.5 +105 o23.5 even + o23.5 even o46.5 -112  
Detroit Lions 264 Lions
u48.5 -110 u23.5 -115 + N/A u23.5 -115 + u23.5 -115 + N/A u23.5 -100 + u24.5 -125 u23.5 -122 + u23.5 -122 u46.5 -108  
Chicago Bears 263 Bears
+180 +185 + N/A +170 + +180 + +180 + +178 + +185 +175 + +175 +230  
Detroit Lions 264 Lions
-218 -220 + N/A -198 + -220 + -250 + -220 + -225 -225 + -225 -278  
Chicago Bears 263 Bears
+4.5 -105 +0.5 -115 + +0.5 -118 + +0.5 -115 + +0.5 -125 + +0.5 -125 + +1.5 -124 + +1.5 -120 +1.5 -118 + +1.5 -118 +6.5 -112  
Detroit Lions 264 Lions
-4.5 -115 -0.5 -105 + -0.5 -110 + -0.5 -105 + -0.5 -105 + -0.5 -105 + -1.5 +102 + -1.5 -110 -1.5 -106 + -1.5 -106 -6.5 -108  
Chicago Bears 263 Bears
o48.5 -110 o7.5 -105 + N/A o7.5 -105 + o7.5 -110 + o8.5 -125 + o8.5 -116 + o8.5 -125 o9.5 -108 + o9.5 -108 o46.5 -112  
Detroit Lions 264 Lions
u48.5 -110 u7.5 -115 + N/A u7.5 -115 + u7.5 -120 + u8.5 -105 + u8.5 -106 + u8.5 -105 u9.5 -115 + u9.5 -115 u46.5 -108  
Chicago Bears 263 Bears
+180 +145 + N/A +145 + +140 + +135 + +146 + +145 +155 + +155 +230  
Detroit Lions 264 Lions
-218 -170 + N/A -180 + -170 + -180 + -184 + -190 -200 + -200 -278  
Chicago Bears 263 Bears
+4.5 -105 +2.5 even + N/A +3.5 -118 + +2.5 even + N/A +2.5 -100 + N/A +2.5 -106 + +2.5 -106 +6.5 -112  
Detroit Lions 264 Lions
-4.5 -115 -2.5 -120 + N/A -3.5 -102 + -2.5 -120 + N/A -2.5 -120 + N/A -2.5 -118 + -2.5 -118 -6.5 -108  
Chicago Bears 263 Bears
o48.5 -110 o23.5 even + N/A o22.5 -115 + o22.5 -115 + N/A o22.5 -120 + N/A o22.5 -124 + o22.5 -124 o46.5 -112  
Detroit Lions 264 Lions
u48.5 -110 u23.5 -120 + N/A u22.5 -105 + u22.5 -105 + N/A u22.5 -100 + N/A u22.5 even + u22.5 even u46.5 -108  
Chicago Bears 263 Bears
+180 +155 + N/A +170 + N/A N/A +156 + N/A +145 + +145 +230  
Detroit Lions 264 Lions
-218 -185 + N/A -205 + N/A N/A -184 + N/A -182 + -182 -278  
Chicago Bears 263 Bears
+4.5 -105 N/A N/A +2.5 -105 + +2.5 -110 + N/A +2.5 -106 + N/A N/A N/A +6.5 -112  
Detroit Lions 264 Lions
-4.5 -115 N/A N/A -2.5 -115 + -2.5 -110 + N/A -2.5 -116 + N/A N/A N/A -6.5 -108  
Chicago Bears 263 Bears
o48.5 -110 o13.5 -125 + N/A o14.5 even + o14.5 -105 + N/A o14.5 -102 + N/A N/A N/A o46.5 -112  
Detroit Lions 264 Lions
u48.5 -110 u13.5 +105 + N/A u14.5 -122 + u14.5 -115 + N/A u14.5 -120 + N/A N/A N/A u46.5 -108  
Chicago Bears 263 Bears
+180 +150 + N/A +154 + +145 + N/A +152 + N/A N/A N/A +230  
Detroit Lions 264 Lions
-218 -180 + N/A -180 + -170 + N/A -188 + N/A N/A N/A -278  
Chicago Bears 263 Bears
+4.5 -105 N/A N/A +0.5 -115 + +1.5 -130 + N/A +1.5 -128 + N/A N/A N/A +6.5 -112  
Detroit Lions 264 Lions
-4.5 -115 N/A N/A -0.5 -105 + -1.5 +110 + N/A -1.5 +106 + N/A N/A N/A -6.5 -108  
Chicago Bears 263 Bears
o48.5 -110 o9.5 -120 + N/A o9.5 -122 + o9.5 -125 + N/A o9.5 -118 + N/A N/A N/A o46.5 -112  
Detroit Lions 264 Lions
u48.5 -110 u9.5 even + N/A u9.5 +102 + u9.5 +105 + N/A u9.5 -102 + N/A N/A N/A u46.5 -108  
Chicago Bears 263 Bears
+180 +140 + N/A +142 + +135 + N/A +138 + N/A N/A N/A +230  
Detroit Lions 264 Lions
-218 -165 + N/A -175 + -165 + N/A -170 + N/A N/A N/A -278  
Chicago Bears 263 Bears
+4.5 -105 +0.5 -105 + N/A +1.5 -112 + +1.5 -120 + N/A +1.5 -128 + N/A N/A N/A +6.5 -112  
Detroit Lions 264 Lions
-4.5 -115 -0.5 -115 + N/A -1.5 -108 + -1.5 even + N/A -1.5 +104 + N/A N/A N/A -6.5 -108  
Chicago Bears 263 Bears
o48.5 -110 o13.5 even + N/A o13.5 even + o13.5 +105 + N/A o13.5 -100 + N/A N/A N/A o46.5 -112  
Detroit Lions 264 Lions
u48.5 -110 u13.5 -120 + N/A u13.5 -120 + u13.5 -125 + N/A u13.5 -122 + N/A N/A N/A u46.5 -108  
Chicago Bears 263 Bears
+180 +130 + N/A +140 + +130 + N/A +126 + N/A N/A N/A +230  
Detroit Lions 264 Lions
-218 -155 + N/A -170 + -160 + N/A -154 + N/A N/A N/A -278  

The Bears will take on the Lions in this week's NFL action. Kickoff is set for 1:00 p.m. EDT at Ford Field in Detroit, Mich. The game will be broadcast live on FOX. Here's everything you need to know about Bears vs. Lions odds, the latest NFL spreads, NFL over/unders and more.

The Lions opened as a -6 point favorite over Bears. The total is set at over/under 46.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 9/12/25

bet365
Bet $5, Get $300 in Bonus Bets Win or Lose!
Bonus Code
VIBONUS
Claim $300
New customers only, 21+ (18+ in KY). Gambling Problem? Call 1-800-GAMBLER. Available in AZ, CO, IA, IL, IN, KS, KY, LA, MD, NC, NJ, OH, PA, TN, VA only. Bet $5 and Get $300 in Bonus Bets at bet365. Registration required. Minimum $10 deposit required. Minimum odds -500 of greater. Bonus Bets wager excluded from returns. T&Cs, time limits and exclusions apply.

Chicago Bears vs. Detroit Lions Best Bet

Whenever there's an island game, there is a propensity to overreact and that's exactly what we got last Monday Night.

After struggling down the stretch with some inaccuracy and sporadic play, Caleb Williams was the punching bag of plenty of sports discourse early this week.

However, for his first game in a new system under Ben Johnson, against one of the game's best defensive coordinators, I think there's a lot of good that Williams can build on.

Despite facing constant pressure all night from one of the more multiple defenses in football, Williams was only sacked twice, and did not commit any turnovers.

This week, he faces a Lions' defense that is talented, but is still breaking in with a new defensive coordinator, Kelvin Sheppard.

The Lions played man coverage on nearly 40% of their dropbacks a season ago, and it looked like more of the same this past week as they were in man coverage on 52% of the Packers' dropbacks. Williams should be able to take advantage of these simpler looks and build off some positives from a week ago.

Six points is too many here. I expect Chicago to keep this one close with the potential to win.

Bears vs. Lions Best Bet: Bears +6.5

(Pick from Derek Mountain)

Looking for more best bets? Check out our free NFL picks and our premium subscription for the best picks!

What Time is the Chicago Bears vs. Detroit Lions Game?

The Chicago Bears will take on the Detroit Lions at 1:00 ET on Sunday, September 14th.

Where is the Chicago Bears vs. Detroit Lions Game Being Played?

This game is going to be played at Ford Field in Detroit, Michigan.

How Can I Watch Bears vs. Lions?

You can watch Bears vs. Lions on FOX.

Can the Bears Beat the Lions?

The Bears can absolutely beat the Lions! Although it is a relatively large spread by NFL standards, there are plenty of upsets week-to-week.

Featured News

Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
•