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Featured Last Updated Sep 12 2025, 11:29 AM

Broncos vs. Colts Week 2 Prediction: Odds, Best Bet

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
8 minute read
Broncos vs. Colts Week 2 Prediction: Odds, Best Bet

Denver Broncos vs. Indianapolis Colts Odds, NFL Week 2

Image Credit: Grace Hollars-USA TODAY Network via Imagn Images

DEN @ IND Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Denver Broncos 271 Broncos
-3.5 -110 -0.5 +105 + -0.5 -110 + -0.5 +105 + -0.5 +105 + -0.5 -105 + +1.5 -140 + -0.5 even -1.5 +110 + -1.5 +110 -1.5 -110  
Indianapolis Colts 272 Colts
+3.5 -110 +0.5 -125 + +0.5 -110 + +0.5 -125 + +0.5 -125 + +0.5 -125 + -1.5 +120 + +0.5 -120 +1.5 -137 + +1.5 -137 +1.5 -110  
Denver Broncos 271 Broncos
o44.5 -110 o21.5 -105 + N/A o20.5 -112 + o21.5 -105 + N/A o21.5 -105 + o22.5 +105 o22.5 -113 + o22.5 -113 o43.5 -108  
Indianapolis Colts 272 Colts
u44.5 -110 u21.5 -115 + N/A u20.5 -108 + u21.5 -115 + N/A u21.5 -115 + u22.5 -125 u22.5 -110 + u22.5 -110 u43.5 -112  
Denver Broncos 271 Broncos
-175 -115 + N/A -115 + -115 + -130 + -110 + -115 -124 + -124 -120  
Indianapolis Colts 272 Colts
+145 -105 + N/A -105 + -105 + even + -110 + -105 even + even even  
Denver Broncos 271 Broncos
-3.5 -110 -0.5 +135 + -0.5 +130 + -0.5 +140 + -0.5 +140 + -0.5 +130 + +1.5 -174 + -0.5 +130 -2.5 +138 + -2.5 +138 -1.5 -110  
Indianapolis Colts 272 Colts
+3.5 -110 +0.5 -160 + +0.5 -165 + +0.5 -170 + +0.5 -170 + +0.5 -170 + -1.5 +142 + +0.5 -170 +2.5 -175 + +2.5 -175 +1.5 -110  
Denver Broncos 271 Broncos
o44.5 -110 o7.5 +105 + N/A o7.5 +102 + o7.5 even + o7.5 -105 + o7.5 +104 + o8.5 -120 o9.5 -110 + o9.5 -110 o43.5 -108  
Indianapolis Colts 272 Colts
u44.5 -110 u7.5 -125 + N/A u7.5 -122 + u7.5 -130 + u7.5 -125 + u7.5 -128 + u8.5 -110 u9.5 -113 + u9.5 -113 u43.5 -112  
Denver Broncos 271 Broncos
-175 -120 + N/A -118 + -130 + -125 + -102 + -120 -121 + -121 -120  
Indianapolis Colts 272 Colts
+145 even + N/A -102 + even + -105 + -120 + -110 -104 + -104 even  
Denver Broncos 271 Broncos
-3.5 -110 -0.5 -115 + N/A -1.5 +114 + -0.5 even + N/A -1.5 +105 + N/A -1.5 +108 + -1.5 +108 -1.5 -110  
Indianapolis Colts 272 Colts
+3.5 -110 +0.5 -105 + N/A +1.5 -135 + +0.5 -120 + N/A +1.5 -125 + N/A +1.5 -137 + +1.5 -137 +1.5 -110  
Denver Broncos 271 Broncos
o44.5 -110 o20.5 -110 + N/A o21.5 -102 + o21.5 -110 + N/A o20.5 -115 + N/A o20.5 -115 + o20.5 -115 o43.5 -108  
Indianapolis Colts 272 Colts
u44.5 -110 u20.5 -110 + N/A u21.5 -118 + u21.5 -110 + N/A u20.5 -105 + N/A u20.5 -108 + u20.5 -108 u43.5 -112  
Denver Broncos 271 Broncos
-175 -135 + N/A -115 + N/A N/A -132 + N/A -132 + -132 -120  
Indianapolis Colts 272 Colts
+145 +115 + N/A -105 + N/A N/A +110 + N/A +106 + +106 even  
Denver Broncos 271 Broncos
-3.5 -110 N/A N/A -0.5 +114 + -1.5 +120 + N/A -1.5 +126 + N/A N/A N/A -1.5 -110  
Indianapolis Colts 272 Colts
+3.5 -110 N/A N/A +0.5 -135 + +1.5 -140 + N/A +1.5 -154 + N/A N/A N/A +1.5 -110  
Denver Broncos 271 Broncos
o44.5 -110 o12.5 -135 + N/A o12.5 -135 + o13.5 +105 + N/A o13.5 -100 + N/A N/A N/A o43.5 -108  
Indianapolis Colts 272 Colts
u44.5 -110 u12.5 +115 + N/A u12.5 +114 + u13.5 -125 + N/A u13.5 -122 + N/A N/A N/A u43.5 -112  
Denver Broncos 271 Broncos
-175 -120 + N/A -115 + -125 + N/A -115 + N/A N/A N/A -120  
Indianapolis Colts 272 Colts
+145 even + N/A -105 + +105 + N/A -105 + N/A N/A N/A even  
Denver Broncos 271 Broncos
-3.5 -110 N/A N/A -0.5 +130 + -1.5 +126 + N/A -1.5 +126 + N/A N/A N/A -1.5 -110  
Indianapolis Colts 272 Colts
+3.5 -110 N/A N/A +0.5 -155 + +1.5 -150 + N/A +1.5 -154 + N/A N/A N/A +1.5 -110  
Denver Broncos 271 Broncos
o44.5 -110 o7.5 -110 + N/A o9.5 -105 + o7.5 -110 + N/A o8.5 -110 + N/A N/A N/A o43.5 -108  
Indianapolis Colts 272 Colts
u44.5 -110 u7.5 -110 + N/A u9.5 -115 + u7.5 -110 + N/A u8.5 -110 + N/A N/A N/A u43.5 -112  
Denver Broncos 271 Broncos
-175 -130 + N/A -115 + -125 + N/A -138 + N/A N/A N/A -120  
Indianapolis Colts 272 Colts
+145 +110 + N/A -105 + +105 + N/A +112 + N/A N/A N/A even  
Denver Broncos 271 Broncos
-3.5 -110 -0.5 +105 + N/A -0.5 +120 + -1.5 +126 + N/A -1.5 +126 + N/A N/A N/A -1.5 -110  
Indianapolis Colts 272 Colts
+3.5 -110 +0.5 -125 + N/A +0.5 -142 + +1.5 -150 + N/A +1.5 -156 + N/A N/A N/A +1.5 -110  
Denver Broncos 271 Broncos
o44.5 -110 o11.5 -115 + N/A o12.5 -108 + o11.5 -110 + N/A o11.5 -116 + N/A N/A N/A o43.5 -108  
Indianapolis Colts 272 Colts
u44.5 -110 u11.5 -105 + N/A u12.5 -112 + u11.5 -110 + N/A u11.5 -106 + N/A N/A N/A u43.5 -112  
Denver Broncos 271 Broncos
-175 -130 + N/A -115 + -120 + N/A -120 + N/A N/A N/A -120  
Indianapolis Colts 272 Colts
+145 +110 + N/A -105 + even + N/A -102 + N/A N/A N/A even  

The Broncos will take on the Colts in this week's NFL action. Kickoff is set for 4:05 p.m. EDT at Lucas Oil Stadium in Indianapolis, Ind. The game will be broadcast live on CBS. Here's everything you need to know about Broncos vs. Colts odds, the latest NFL spreads, NFL over/unders and more.

The Broncos opened as a -1.5 point favorite over Colts. The total is set at over/under 43.5 total points scored by both teams combined.

Be sure to check out the latest NFL Odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

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Denver Broncos vs. Indianapolis Colts Best Bet

Warren put together an incredible debut from a usage perspective. He paced Indianapolis with 7 catches on 9 targets, while finishing 2nd with 76 receiving yards. The rookie ranked 10th among all pass catchers in target share, 6th in targets per route run (minimum 20 routes), and 8th in yards per route run (minimum 20 routes). Warren posted a healthy 30% 1st read target share.

Denver unsurprisingly stifled the Titans in Cam Ward's first start. They'll be a much tougher matchup than Indianapolis had in Week 1 against Miami. The best way to attack the Broncos is with slot receivers and tight ends to avoid Patrick Surtain and company. Warren should once again lead the team in opportunities.

Denver Broncos vs. Indianapolis Colts Best Bet: Tyler Warren o43.5 Receiving Yards (-110)

(Pick via Charlie Wright)


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What Time is the Denver Broncos vs. Indianapolis Colts Game?

The Denver Broncos will take on the Indianapolis Colts at 4:05 ET on Sunday, September 14th.

Where is the Denver Broncos vs. Indianapolis Colts Game Being Played?

This game is going to be played at Lucas Oil Stadium in Indianapolis, IN.

How Can I Watch the Denver Broncos vs. Indianapolis Colts?

You can watch The Broncos vs. The Colts on CBS.

Can The Broncos Beat The Colts?

The Broncos can certainly beat Indianapolis. The Broncos are actually favorites in this game so they are more likely to win than the Colts.

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 2 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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