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Featured Last Updated Sep 19 2025, 9:45 AM

Arizona Cardinals vs. San Francisco 49ers Week 3 Prediction: Odds, Best Bet

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
8 minute read
Arizona Cardinals vs. San Francisco 49ers Week 3 Prediction: Odds, Best Bet

Arizona Cardinals vs. San Francisco 49ers Odds, NFL Week 3

Image Credit: Brett Davis-Imagn Images

ARI @ SF Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Arizona Cardinals 475 Cardinals
+3.5 -110 +0.5 -115 + +0.5 -115 + +0.5 -110 + +0.5 -115 + +0.5 -120 +1.5 -120 + +1.5 -125 +1.5 -120 + +1.5 -120 +3 -120  
San Francisco 49ers 476 49ers
-3.5 -110 -0.5 -105 + -0.5 -105 + -0.5 -110 + -0.5 -105 + -0.5 -110 -1.5 -100 + -1.5 +105 -1.5 -104 + -1.5 -104 -3 even  
Arizona Cardinals 475 Cardinals
o47.5 -115 o23.5 even + N/A o22.5 -125 + o23 -105 + N/A o23.5 +105 + o22.5 -125 o22.5 -124 + o22.5 -124 o45.5 -115  
San Francisco 49ers 476 49ers
u47.5 -105 u23.5 -120 + N/A u22.5 +105 + u23 -115 + N/A u23.5 -125 + u22.5 +105 u22.5 even + u22.5 even u45.5 -105  
Arizona Cardinals 475 Cardinals
+150 +105 + N/A +105 + +105 + even + +112 + +105 +110 + +110 +136  
San Francisco 49ers 476 49ers
-180 -125 + N/A -125 + -125 + -130 + -136 + -125 -136 + -136 -162  
Arizona Cardinals 475 Cardinals
+3.5 -110 +0.5 -160 + +0.5 -155 + +0.5 -162 + +0.5 -160 + N/A +1.5 -164 + +1.5 -180 +1.5 -165 + +1.5 -165 +3 -120  
San Francisco 49ers 476 49ers
-3.5 -110 -0.5 +135 + -0.5 +118 + -0.5 +136 + -0.5 +130 + N/A -1.5 +134 + -1.5 +130 -1.5 +132 + -1.5 +132 -3 even  
Arizona Cardinals 475 Cardinals
o47.5 -115 o7.5 -105 + N/A o7.5 -105 + o7.5 -105 + N/A o7.5 -106 + o8.5 -105 o7.5 even + o7.5 even o45.5 -115  
San Francisco 49ers 476 49ers
u47.5 -105 u7.5 -115 + N/A u7.5 -115 + u7.5 -125 + N/A u7.5 -116 + u8.5 -125 u7.5 -124 + u7.5 -124 u45.5 -105  
Arizona Cardinals 475 Cardinals
+150 even + N/A even + even + N/A +106 + even +108 + +108 +136  
San Francisco 49ers 476 49ers
-180 -120 + N/A -120 + -130 + N/A -130 + -130 -134 + -134 -162  
Arizona Cardinals 475 Cardinals
+3.5 -110 N/A N/A +0.5 -122 + +0.5 -130 + N/A +1.5 -136 + N/A N/A N/A +3 -120  
San Francisco 49ers 476 49ers
-3.5 -110 N/A N/A -0.5 +102 + -0.5 +110 + N/A -1.5 +112 + N/A N/A N/A -3 even  
Arizona Cardinals 475 Cardinals
o47.5 -115 o13.5 -105 + N/A o13.5 -112 + o13.5 +105 + N/A o13.5 -118 + N/A N/A N/A o45.5 -115  
San Francisco 49ers 476 49ers
u47.5 -105 u13.5 -115 + N/A u13.5 -108 + u13.5 -125 + N/A u13.5 -104 + N/A N/A N/A u45.5 -105  
Arizona Cardinals 475 Cardinals
+150 +115 + N/A +105 + +105 + N/A +106 + N/A N/A N/A +136  
San Francisco 49ers 476 49ers
-180 -135 + N/A -125 + -125 + N/A -130 + N/A N/A N/A -162  
Arizona Cardinals 475 Cardinals
+3.5 -110 N/A N/A +0.5 -135 + +0.5 -135 + N/A +1.5 -158 + N/A N/A N/A +3 -120  
San Francisco 49ers 476 49ers
-3.5 -110 N/A N/A -0.5 +114 + -0.5 +115 + N/A -1.5 +130 + N/A N/A N/A -3 even  
Arizona Cardinals 475 Cardinals
o47.5 -115 o9.5 -120 + N/A o9.5 -115 + o9.5 -115 + N/A o9.5 -110 + N/A N/A N/A o45.5 -115  
San Francisco 49ers 476 49ers
u47.5 -105 u9.5 even + N/A u9.5 -105 + u9.5 -105 + N/A u9.5 -110 + N/A N/A N/A u45.5 -105  
Arizona Cardinals 475 Cardinals
+150 +105 + N/A +114 + +115 + N/A +106 + N/A N/A N/A +136  
San Francisco 49ers 476 49ers
-180 -125 + N/A -135 + -135 + N/A -130 + N/A N/A N/A -162  
Arizona Cardinals 475 Cardinals
+3.5 -110 +0.5 -135 + N/A +0.5 -115 + +0.5 -115 + N/A +1.5 -148 + N/A N/A N/A +3 -120  
San Francisco 49ers 476 49ers
-3.5 -110 -0.5 +115 + N/A -0.5 -105 + -0.5 -105 + N/A -1.5 +122 + N/A N/A N/A -3 even  
Arizona Cardinals 475 Cardinals
o47.5 -115 o13 -110 + N/A o13.5 +105 + o13.5 even + N/A o12.5 -124 + N/A N/A N/A o45.5 -115  
San Francisco 49ers 476 49ers
u47.5 -105 u13 -110 + N/A u13.5 -125 + u13.5 -120 + N/A u12.5 +102 + N/A N/A N/A u45.5 -105  
Arizona Cardinals 475 Cardinals
+150 even + N/A +114 + -10000 + N/A +104 + N/A N/A N/A +136  
San Francisco 49ers 476 49ers
-180 -120 + N/A -135 + -10000 + N/A -128 + N/A N/A N/A -162  
Arizona Cardinals 475 Cardinals
+3.5 -110 +0.5 -125 + N/A N/A +1.5 -115 + N/A +1.5 -125 + N/A +1.5 -132 + +1.5 -132 +3 -120  
San Francisco 49ers 476 49ers
-3.5 -110 -0.5 +105 + N/A N/A -1.5 -105 + N/A -1.5 +105 + N/A -1.5 +107 + -1.5 +107 -3 even  
Arizona Cardinals 475 Cardinals
o47.5 -115 o21.5 even + N/A N/A o22.5 -115 + N/A o22.5 -110 + N/A o22.5 -109 + o22.5 -109 o45.5 -115  
San Francisco 49ers 476 49ers
u47.5 -105 u21.5 -120 + N/A N/A u22.5 -105 + N/A u22.5 -110 + N/A u22.5 -114 + u22.5 -114 u45.5 -105  
Arizona Cardinals 475 Cardinals
+150 -105 + N/A N/A N/A N/A +112 + N/A +108 + +108 +136  
San Francisco 49ers 476 49ers
-180 -115 + N/A N/A N/A N/A -132 + N/A -136 + -136 -162  

The Cardinals will take on the 49ers in this week's NFL action. Kickoff is set for 4:25 p.m. EDT at Levi's Stadium in Santa Clara, Calif. The game will be broadcast live on FOX. Here's everything you need to know about Cardinals vs. 49ers odds, the latest NFL spreads, NFL over/unders and more.

The 49ers opened as a -2.5 point favorite over Cardinals. The total is set at over/under 45 total points scored by both teams combined.

Be sure to check out the latest NFL Odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

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Arizona Cardinals vs. San Francisco 49ers Best Bet

I don't think it's right to hop right back on the Niners' offense after one good Mac Jones game against one of the worst secondaries in football.

I especially don't feel good about that, given the Cardinals have performed exceptionally against the pass through two weeks, ranking third-best in explosive play rate through the air and grading out as the seventh-best cover unit according to PFF.

Arizona's been able to slow the run, too, so why not bet on this team against a San Francisco offense weakened by the loss of Brock Purdy and several key pass-catchers?

A terribly easy schedule to open up the season is why, but I feel like I've talked myself into the Cardinals as this blurb has gone on. It's not like the 49ers have been able to stop the run, and that's what's led Arizona to a 2-0 record.

Sure, let's do it.

Arizona Cardinals vs. San Francisco 49ers Best Bet: Cardinals +3 (-120)

(Pick via Kenny Ducey)


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What Time is the Arizona Cardinals vs. San Francisco 49ers Game?

The Arizona Cardinals vs. San Francisco 49ers play at 4:25 PM ET on Sunday, September 21st.

Where is the Arizona Cardinals vs. San Francisco 49ers Game Being Played?

This game is going to be played at Levi's Stadium in Santa Clara, CA.

How Can I Watch the Arizona Cardinals vs. San Francisco 49ers?

You can watch Arizona Cardinals vs. San Francisco 49ers on FOX.

Can The 49ers Beat The Cardinals?

The 49ers are a 2.5-point favorite against the Cardinals. Anything can happen in the NFL!

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 2 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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