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Featured Last Updated Oct 17 2025, 9:43 AM

NFL: Indianapolis Colts vs. Los Angeles Chargers: Prediction, Odds, Best Bet

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
8 minute read
NFL: Indianapolis Colts vs. Los Angeles Chargers: Prediction, Odds, Best Bet

Featured Image Credit: Trevor Ruszkowski-Imagn Images

NYG @ DEN Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
New York Giants 467 Giants
+7.5 -112 +4 -115 + +4.5 -130 + +3.5 -102 + +3.5 -102 + +3.5 even + +4.5 -120 + +3.5 even + +3.5 +105 +3.5 -103 + +7 -105  
Denver Broncos 468 Broncos
-7.5 -108 -4 -105 + -4.5 even + -3.5 -118 + -3.5 -121 + -3.5 -130 + -4.5 -100 + -3.5 -120 + -3.5 -125 -3.5 -122 + -7 -115  
New York Giants 467 Giants
o42.5 -110 o20 -110 + N/A o20.5 +102 + o20.5 -103 + N/A o20.5 +105 + o20.5 +105 + o20.5 +105 o20.5 +107 + o39.5 -115  
Denver Broncos 468 Broncos
u42.5 -110 u20 -110 + N/A u20.5 -122 + u20.5 -120 + N/A u20.5 -125 + u20.5 -125 + u20.5 -125 u20.5 -132 + u39.5 -105  
New York Giants 467 Giants
+260 +200 + +220 + +200 + +205 + +190 + +215 + N/A +200 +200 + +300  
Denver Broncos 468 Broncos
-325 -245 + -275 + -245 + -265 + -260 + -270 + N/A -250 -250 + -395  
New York Giants 467 Giants
+7.5 -112 +0.5 -105 + +0.5 -118 + +0.5 -115 + N/A +0.5 -120 + +1.5 -116 + +0.5 -115 + +1.5 -125 +1.5 -120 + +7 -105  
Denver Broncos 468 Broncos
-7.5 -108 -0.5 -115 + -0.5 -110 + -0.5 -105 + N/A -0.5 -110 + -1.5 -108 + -0.5 -105 + -1.5 -105 -1.5 -105 + -7 -115  
New York Giants 467 Giants
o42.5 -110 o7.5 +115 + N/A o7.5 +120 + N/A o7.5 +115 + o7.5 +130 + o7.5 +130 + o8.5 +105 o7.5 +118 + o39.5 -115  
Denver Broncos 468 Broncos
u42.5 -110 u7.5 -135 + N/A u7.5 -142 + N/A u7.5 -145 + u7.5 -156 + u7.5 -155 + u8.5 -140 u7.5 -148 + u39.5 -105  
New York Giants 467 Giants
+260 +165 + +155 + +160 + N/A +140 + +168 + N/A +150 +163 + +300  
Denver Broncos 468 Broncos
-325 -200 + -200 + -185 + N/A -190 + -215 + N/A -200 -205 + -395  
New York Giants 467 Giants
+7.5 -112 +3.5 -110 + N/A +3.5 -102 + N/A N/A +3.5 -110 + N/A N/A +3.5 -118 + +7 -105  
Denver Broncos 468 Broncos
-7.5 -108 -3.5 -110 + N/A -3.5 -118 + N/A N/A -3.5 -110 + N/A N/A -3.5 -106 + -7 -115  
New York Giants 467 Giants
o42.5 -110 o20 -110 + N/A o18.5 -115 + N/A N/A o19.5 -110 + o19.5 -120 + N/A o19.5 -124 + o39.5 -115  
Denver Broncos 468 Broncos
u42.5 -110 u20 -110 + N/A u18.5 -105 + N/A N/A u19.5 -110 + u19.5 -110 + N/A u19.5 even + u39.5 -105  
New York Giants 467 Giants
+260 +165 + N/A +205 + N/A N/A +190 + N/A N/A +180 + +300  
Denver Broncos 468 Broncos
-325 -200 + N/A -250 + N/A N/A -230 + N/A N/A -230 + -395  
New York Giants 467 Giants
+7.5 -112 N/A N/A +2.5 +102 + N/A N/A +2.5 +110 + +2.5 +105 + N/A N/A +7 -105  
Denver Broncos 468 Broncos
-7.5 -108 N/A N/A -2.5 -122 + N/A N/A -2.5 -134 + -2.5 -135 + N/A N/A -7 -115  
New York Giants 467 Giants
o42.5 -110 o10.5 -110 + N/A o12.5 -122 + N/A N/A o12.5 -128 + o12.5 -130 + N/A N/A o39.5 -115  
Denver Broncos 468 Broncos
u42.5 -110 u10.5 -110 + N/A u12.5 +102 + N/A N/A u12.5 +106 + u12.5 even + N/A N/A u39.5 -105  
New York Giants 467 Giants
+260 +200 + N/A +164 + N/A N/A +180 + N/A N/A N/A +300  
Denver Broncos 468 Broncos
-325 -245 + N/A -205 + N/A N/A -230 + N/A N/A N/A -395  
New York Giants 467 Giants
+7.5 -112 N/A N/A +1.5 -112 + N/A N/A +1.5 -112 + +1.5 -115 + N/A N/A +7 -105  
Denver Broncos 468 Broncos
-7.5 -108 N/A N/A -1.5 -108 + N/A N/A -1.5 -108 + -1.5 -115 + N/A N/A -7 -115  
New York Giants 467 Giants
o42.5 -110 o7.5 -105 + N/A o7.5 +110 + N/A N/A o7.5 +106 + o7.5 +105 + N/A N/A o39.5 -115  
Denver Broncos 468 Broncos
u42.5 -110 u7.5 -115 + N/A u7.5 -130 + N/A N/A u7.5 -128 + u7.5 -135 + N/A N/A u39.5 -105  
New York Giants 467 Giants
+260 +165 + N/A +170 + N/A N/A +168 + N/A N/A N/A +300  
Denver Broncos 468 Broncos
-325 -200 + N/A -198 + N/A N/A -210 + N/A N/A N/A -395  
New York Giants 467 Giants
+7.5 -112 +0.5 -110 + N/A +2.5 -108 + N/A N/A +1.5 -114 + N/A N/A N/A +7 -105  
Denver Broncos 468 Broncos
-7.5 -108 -0.5 -110 + N/A -2.5 -112 + N/A N/A -1.5 -110 + N/A N/A N/A -7 -115  
New York Giants 467 Giants
o42.5 -110 o10.5 -110 + N/A o10.5 +114 + N/A N/A o10.5 +106 + o10.5 even + N/A N/A o39.5 -115  
Denver Broncos 468 Broncos
u42.5 -110 u10.5 -110 + N/A u10.5 -135 + N/A N/A u10.5 -130 + u10.5 -130 + N/A N/A u39.5 -105  
New York Giants 467 Giants
+260 +145 + N/A +164 + N/A N/A +146 + N/A N/A N/A +300  
Denver Broncos 468 Broncos
-325 -170 + N/A -198 + N/A N/A -180 + N/A N/A N/A -395  

The Colts will take on the Chargers in this week's NFL action. Kickoff is set for 4:05 p.m. EDT at SoFi Stadium in Inglewood, Calif. The game will be broadcast live on CBS. Here's everything you need to know about Colts vs. Chargers odds, the latest NFL spreads, NFL over/unders and more.

The Chargers opened as a -1.5 point favorite over Colts. The total is set at over/under 48.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Check out my full list of NFL Week 7 best bets.

Updated on 10/17/25

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Indianapolis Colts vs. Los Angeles Chargers Best Bet

The Chargers are decimated, especially the RB room. Najee Harris and Omarion Hampton are both on the IL, and Kimani Vidal is currently RB1. Joe Alt is questionable, and he is desperately needed on this offensive line that has been abysmal. Laiatu Latu for the Colts has been amazing, coming in as the 7th-rated edge defender, and I am not sure how the Chargers are going to be able to stop him.

Indianapolis Colts vs. Los Angeles Chargers Best Bet: Indianapolis Colts Moneyline (+112)

(Pick from Dylan Wilkerson)


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What Time is the Indianapolis Colts vs. Los Angeles Chargers Game?

The Indianapolis Colts vs. Los Angeles Chargers game is at 8:20 PM ET on Sunday, October 19th.

Where is the Indianapolis Colts vs. Los Angeles Chargers Game Being Played?

This game will be played at Levi's Stadium in Santa Clara, Calif.

How Can I Watch Indianapolis Colts vs. Los Angeles Chargers?

You can watch Indianapolis Colts vs. Los Angeles Chargers on NBC.

Can the Colts Beat the Chargers?

Of course! The Coltsa are only a 1.5 point underdog so anyone can win.

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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