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Featured Last Updated Sep 25 2025, 1:13 PM

NFL: Chargers vs. Giants, Prediction, Odds, Best Bet

Derek Mountain
Derek Mountain Sports Betting Expert
8 minute read
NFL: Chargers vs. Giants, Prediction, Odds, Best Bet

Featured Image Credit: Jayne Kamin-Oncea via Imagn Images

LAC @ NYG Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Los Angeles Chargers 265 Chargers
-3.5 -110 -3.5 -110 + -3.5 -110 + -3.5 -110 + -3.5 -110 + -3.5 -110 + -3.5 -110 + -4.5 +115 -3.5 -106 + -3.5 -105 -6 -110  
New York Giants 266 Giants
+3.5 -110 +3.5 -110 + +3.5 -110 + +3.5 -110 + +3.5 -110 + +3.5 -120 + +3.5 -110 + +4.5 -140 +3.5 -118 + +3.5 -115 +6 -110  
Los Angeles Chargers 265 Chargers
o43.5 -110 o22.5 -105 + N/A o22.5 -118 + o22.5 -110 + N/A o22.5 -110 + o22.5 -115 o22.5 -115 + o22.5 -110 o43.5 -115  
New York Giants 266 Giants
u43.5 -110 u22.5 -115 + N/A u22.5 -102 + u22.5 -110 + N/A u22.5 -110 + u22.5 -105 u22.5 -108 + u22.5 -110 u43.5 -105  
Los Angeles Chargers 265 Chargers
-175 -220 + N/A -218 + -220 + -200 + -220 + -210 -210 + N/A -285  
New York Giants 266 Giants
+145 +180 + N/A +180 + +180 + +150 + +176 + +175 +165 + N/A +230  
Los Angeles Chargers 265 Chargers
-3.5 -110 -0.5 -105 + -0.5 -102 + -0.5 even + -0.5 -105 + N/A -1.5 -100 + -0.5 -105 -1.5 +107 + -0.5 even -6 -110  
New York Giants 266 Giants
+3.5 -110 +0.5 -115 + +0.5 -125 + +0.5 -120 + +0.5 -125 + N/A +1.5 -122 + +0.5 -125 +1.5 -132 + +0.5 -120 +6 -110  
Los Angeles Chargers 265 Chargers
o43.5 -110 o7.5 -105 + N/A o7.5 -108 + o7.5 -105 + N/A o7.5 +102 + o8.5 -105 o7.5 -106 + o7.5 even o43.5 -115  
New York Giants 266 Giants
u43.5 -110 u7.5 -115 + N/A u7.5 -112 + u7.5 -125 + N/A u7.5 -126 + u8.5 -125 u7.5 -118 + u7.5 -120 u43.5 -105  
Los Angeles Chargers 265 Chargers
-175 -180 + N/A -175 + -180 + N/A -188 + -190 -180 + N/A -285  
New York Giants 266 Giants
+145 +150 + N/A +145 + +150 + N/A +152 + +145 +143 + N/A +230  
Los Angeles Chargers 265 Chargers
-3.5 -110 -3 -110 + N/A -3.5 +102 + -3.5 -115 + N/A -3.5 -100 + N/A -3.5 even + N/A -6 -110  
New York Giants 266 Giants
+3.5 -110 +3 -110 + N/A +3.5 -122 + +3.5 -105 + N/A +3.5 -120 + N/A +3.5 -124 + N/A +6 -110  
Los Angeles Chargers 265 Chargers
o43.5 -110 o20.5 -110 + N/A o20.5 -120 + o20.5 -115 + N/A o20.5 -115 + N/A o20.5 -108 + o20.5 -120 o43.5 -115  
New York Giants 266 Giants
u43.5 -110 u20.5 -110 + N/A u20.5 even + u20.5 -105 + N/A u20.5 -105 + N/A u20.5 -115 + u20.5 -110 u43.5 -105  
Los Angeles Chargers 265 Chargers
-175 -170 + N/A -192 + N/A N/A -210 + N/A -205 + N/A -285  
New York Giants 266 Giants
+145 +145 + N/A +160 + N/A N/A +174 + N/A +160 + N/A +230  
Los Angeles Chargers 265 Chargers
-3.5 -110 N/A N/A -2.5 -118 + -2.5 -120 + N/A -2.5 -116 + N/A N/A -2.5 -120 -6 -110  
New York Giants 266 Giants
+3.5 -110 N/A N/A +2.5 -102 + +2.5 even + N/A +2.5 -106 + N/A N/A +2.5 -110 +6 -110  
Los Angeles Chargers 265 Chargers
o43.5 -110 o13 -105 + N/A o13.5 even + o13.5 even + N/A o13.5 -104 + N/A N/A o13.5 even o43.5 -115  
New York Giants 266 Giants
u43.5 -110 u13 -115 + N/A u13.5 -120 + u13.5 -120 + N/A u13.5 -118 + N/A N/A u13.5 -130 u43.5 -105  
Los Angeles Chargers 265 Chargers
-175 -220 + N/A -185 + -190 + N/A -188 + N/A N/A N/A -285  
New York Giants 266 Giants
+145 +180 + N/A +154 + +160 + N/A +152 + N/A N/A N/A +230  
Los Angeles Chargers 265 Chargers
-3.5 -110 N/A N/A -0.5 -105 + -0.5 -110 + N/A -1.5 -102 + N/A N/A -0.5 -115 -6 -110  
New York Giants 266 Giants
+3.5 -110 N/A N/A +0.5 -115 + +0.5 -110 + N/A +1.5 -120 + N/A N/A +0.5 -115 +6 -110  
Los Angeles Chargers 265 Chargers
o43.5 -110 o9.5 -110 + N/A o8.5 -115 + o8.5 -115 + N/A o8.5 -116 + N/A N/A o8.5 -120 o43.5 -115  
New York Giants 266 Giants
u43.5 -110 u9.5 -110 + N/A u8.5 -105 + u8.5 -105 + N/A u8.5 -106 + N/A N/A u8.5 -110 u43.5 -105  
Los Angeles Chargers 265 Chargers
-175 -180 + N/A -175 + -175 + N/A -188 + N/A N/A N/A -285  
New York Giants 266 Giants
+145 +150 + N/A +145 + +150 + N/A +152 + N/A N/A N/A +230  
Los Angeles Chargers 265 Chargers
-3.5 -110 -0.5 -105 + N/A -0.5 -115 + -1.5 even + N/A -1.5 -102 + N/A N/A -2.5 -130 -6 -110  
New York Giants 266 Giants
+3.5 -110 +0.5 -115 + N/A +0.5 -105 + +1.5 -120 + N/A +1.5 -120 + N/A N/A +2.5 even +6 -110  
Los Angeles Chargers 265 Chargers
o43.5 -110 o12.5 -110 + N/A o12.5 -108 + o11.5 -115 + N/A o11.5 -110 + N/A N/A o11.5 -115 o43.5 -115  
New York Giants 266 Giants
u43.5 -110 u12.5 -110 + N/A u12.5 -112 + u11.5 -105 + N/A u11.5 -110 + N/A N/A u11.5 -115 u43.5 -105  
Los Angeles Chargers 265 Chargers
-175 -150 + N/A -155 + -165 + N/A -168 + N/A N/A N/A -285  
New York Giants 266 Giants
+145 +125 + N/A +130 + +145 + N/A +136 + N/A N/A N/A +230  

The Chargers will take on the Giants in this week's NFL action. Kickoff is set for 1:00 p.m. EDT at MetLife Stadium in East Rutherford, N.J. The game will be broadcast live on CBS. Here's everything you need to know about Chargers vs. Giants odds, the latest NFL spreads, NFL over/unders and more.

The Chargers opened as a -6.5 point favorite over Giants. The total is set at over/under 44 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

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Los Angeles Chargers vs. New York Giants Best Bet

The Chargers are really good, but can they make our lives a little bit easier?

Justin Herbert threw for 300 yards against Denver, but he was sacked five times and came home with a measly 6.4 yards per attempt. The Chargers stopped Bo Nix in his tracks, but that's been a common theme this year. The run defense and the tackling continue to be brutal, and that's giving me a lot of pause.

We know L.A. loves to air it out, but thus far it's completed just four passes of 20 or more yards despite ranking near the top of the league with 14 attempts.

The Giants have allowed a sub-30% completion percentage on these throws, and they've also run the ball quite admirably — something the Chargers have had a tough time stopping.

It's going to be Jaxson Dart's first career start, and it's also going to be another tall task for a shaky Giants defense to slow down a complete Chargers team that can also run the ball quite well.

With that said, we saw Herbert struggle against Denver's pass rush, and New York's isn't too bad. If we had more of an assurance at quarterback I'd be all over the home underdogs.

Chargers vs. Giants Best Bet: Lean Giants +6.5

(Pick from Kenny Ducey)

Looking for more best bets? Check out our free NFL picks and our premium subscription for the best picks!

What Time is the Los Angeles Chargers vs. New York Giants Game?

The Los Angeles Chargers vs. New York Giants game is at 1:00 PM ET on Sunday, September 28th.

Where is the Los Angeles Chargers vs. New York Giants Being Played?

This game will be played at MetLife Stadium in East Rutherford, New Jersey.

How Can I Watch Chargers vs. Giants?

You can watch Chargers vs. Giants on CBS.

Can the Giants Beat the Chargers?

The Giants and rookie Jaxson Dart will need to bring their A-game to take down the undefeated LA Chargers.

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Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
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