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Featured Last Updated Sep 5 2025, 5:55 PM

Friday Night Football: Chiefs vs. Chargers, Prediction, Odds, Best Bet

Derek Mountain
Derek Mountain Sports Betting Expert
8 minute read
Friday Night Football: Chiefs vs. Chargers, Prediction, Odds, Best Bet

Image Credit: Kirby Lee/USA Today Network via Imagn Images

KC @ LAC Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Kansas City Chiefs 453 Chiefs
-3 -110 -1.5 -110 + -2.5 -110 + -1.5 -112 + -1.5 -110 + -1.5 -115 + -1.5 -110 + -2.5 even -2.5 -109 + -2.5 -109 -3 -118  
Los Angeles Chargers 454 Chargers
+3 -110 +1.5 -110 + +2.5 -120 + +1.5 -108 + +1.5 -110 + +1.5 -115 + +1.5 -110 + +2.5 -120 +2.5 -114 + +2.5 -114 +3 -102  
Kansas City Chiefs 453 Chiefs
o44.5 -110 N/A N/A N/A N/A N/A N/A o10.5 +125 N/A N/A o47.5 -110  
Los Angeles Chargers 454 Chargers
u44.5 -110 N/A N/A N/A N/A N/A N/A u10.5 -165 N/A N/A u47.5 -110  
Kansas City Chiefs 453 Chiefs
-155 -152 + -155 + -148 + -145 + -145 + -148 + -145 -159 + -159 -175  
Los Angeles Chargers 454 Chargers
+130 +125 + +125 + +124 + +122 + +115 + +122 + +120 +128 + +128 +145  
Kansas City Chiefs 453 Chiefs
-3 -110 -0.5 +120 + -0.5 +110 + -0.5 +114 + -0.5 +110 + -0.5 +115 + -1.5 +124 + -0.5 +110 -1.5 +120 + -1.5 +120 -3 -118  
Los Angeles Chargers 454 Chargers
+3 -110 +0.5 -142 + +0.5 -140 + +0.5 -135 + +0.5 -140 + +0.5 -145 + +1.5 -152 + +0.5 -145 +1.5 -152 + +1.5 -152 +3 -102  
Kansas City Chiefs 453 Chiefs
o44.5 -110 N/A N/A N/A N/A N/A N/A o4.5 -120 N/A N/A o47.5 -110  
Los Angeles Chargers 454 Chargers
u44.5 -110 N/A N/A N/A N/A N/A N/A u4.5 -110 N/A N/A u47.5 -110  
Kansas City Chiefs 453 Chiefs
-155 -136 + -135 + -142 + -140 + -135 + -134 + -140 -143 + -143 -175  
Los Angeles Chargers 454 Chargers
+130 +115 + +105 + +120 + +110 + +105 + +110 + +105 +117 + +117 +145  
Kansas City Chiefs 453 Chiefs
-3 -110 -1.5 -115 + N/A -1.5 -115 + -1.5 -105 + N/A -1.5 -110 + N/A -1.5 -108 + -1.5 -108 -3 -118  
Los Angeles Chargers 454 Chargers
+3 -110 +1.5 -105 + N/A +1.5 -105 + +1.5 -115 + N/A +1.5 -110 + N/A +1.5 -115 + +1.5 -115 +3 -102  
Kansas City Chiefs 453 Chiefs
o44.5 -110 o22.5 -115 + N/A o23.5 -105 + o23.5 -115 + N/A o23.5 -105 + N/A o23.5 -107 + o23.5 -107 o47.5 -110  
Los Angeles Chargers 454 Chargers
u44.5 -110 u22.5 -105 + N/A u23.5 -115 + u23.5 -105 + N/A u23.5 -115 + N/A u23.5 -117 + u23.5 -117 u47.5 -110  
Kansas City Chiefs 453 Chiefs
-155 -157 + N/A -155 + N/A N/A -146 + N/A -152 + -152 -175  
Los Angeles Chargers 454 Chargers
+130 +130 + N/A +130 + N/A N/A +124 + N/A +120 + +120 +145  
Kansas City Chiefs 453 Chiefs
-3 -110 N/A N/A -0.5 -105 + -1.5 +105 + N/A -1.5 +102 + N/A N/A N/A -3 -118  
Los Angeles Chargers 454 Chargers
+3 -110 N/A N/A +0.5 -115 + +1.5 -125 + N/A +1.5 -126 + N/A N/A N/A +3 -102  
Kansas City Chiefs 453 Chiefs
o44.5 -110 o13.5 -115 + N/A o13.5 -112 + o13.5 -120 + N/A o14.5 +102 + N/A N/A N/A o47.5 -110  
Los Angeles Chargers 454 Chargers
u44.5 -110 u13.5 -105 + N/A u13.5 -108 + u13.5 even + N/A u14.5 -124 + N/A N/A N/A u47.5 -110  
Kansas City Chiefs 453 Chiefs
-155 -136 + N/A -135 + -140 + N/A -144 + N/A N/A N/A -175  
Los Angeles Chargers 454 Chargers
+130 +115 + N/A +114 + +118 + N/A +118 + N/A N/A N/A +145  
Kansas City Chiefs 453 Chiefs
-3 -110 N/A N/A -0.5 +120 + -1.5 +126 + N/A -1.5 +118 + N/A N/A N/A -3 -118  
Los Angeles Chargers 454 Chargers
+3 -110 N/A N/A +0.5 -142 + +1.5 -150 + N/A +1.5 -148 + N/A N/A N/A +3 -102  
Kansas City Chiefs 453 Chiefs
o44.5 -110 o9.5 -110 + N/A o9.5 -110 + o9.5 -120 + N/A o9.5 -132 + N/A N/A N/A o47.5 -110  
Los Angeles Chargers 454 Chargers
u44.5 -110 u9.5 -110 + N/A u9.5 -110 + u9.5 even + N/A u9.5 +108 + N/A N/A N/A u47.5 -110  
Kansas City Chiefs 453 Chiefs
-155 -131 + N/A -130 + -140 + N/A -142 + N/A N/A N/A -175  
Los Angeles Chargers 454 Chargers
+130 +110 + N/A +110 + +118 + N/A +116 + N/A N/A N/A +145  
Kansas City Chiefs 453 Chiefs
-3 -110 -0.5 even + N/A -0.5 +102 + -1.5 +118 + N/A -1.5 +116 + N/A N/A N/A -3 -118  
Los Angeles Chargers 454 Chargers
+3 -110 +0.5 -120 + N/A +0.5 -122 + +1.5 -140 + N/A +1.5 -140 + N/A N/A N/A +3 -102  
Kansas City Chiefs 453 Chiefs
o44.5 -110 o12.5 -115 + N/A o12.5 -115 + o12.5 -120 + N/A o13.5 +102 + N/A N/A N/A o47.5 -110  
Los Angeles Chargers 454 Chargers
u44.5 -110 u12.5 -105 + N/A u12.5 -105 + u12.5 even + N/A u13.5 -126 + N/A N/A N/A u47.5 -110  
Kansas City Chiefs 453 Chiefs
-155 -131 + N/A -130 + -135 + N/A -134 + N/A N/A N/A -175  
Los Angeles Chargers 454 Chargers
+130 +110 + N/A +110 + +115 + N/A +110 + N/A N/A N/A +145  

The Chiefs will take on the Chargers in this week's NFL action. Kickoff is set for 8:00 p.m. EDT at Arena Corinthians in São Paulo, Brazil. The game will be broadcast live on YouTube. Here's everything you need to know about Chiefs vs. Chargers odds, the latest NFL spreads, NFL over/unders and more.

The Chiefs opened as a -3 point favorite over Chargers. The total is set at over/under 46.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 9/5/25

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Kansas City Chiefs vs. Los Angeles Chargers Best Bet

Kelce has had an amazing run-out in life. He's won 3 Super Bowls and is now engaged to one of the most famous people in the world. I generally prefer to bet overs rather than unders given the fact that I find them more fun to sweat, but I'm taking the under on the near 36-year-old veteran in his Week 1 matchup against the Chargers. His target share has diminished over the last couple of seasons, both of these teams want to run the ball (which means fewer plays for each offense), and this has historically been a difficult matchup for him. He's been held to 45 or fewer receiving yards in 3 of his last 4 games against the Chargers when Derwin James has been active.

Chiefs vs. Chargers Best Bet: Travis Kelce u49.5 Receiving Yards (-110)

(Pick from Derek Farnsworth)


PLACE THIS BET INSTANTLY AT bet365!

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What Time is the Kansas City Chiefs vs. Los Angeles Chargers Game?

The Kansas City Chiefs will take on the Los Angles Chargers at 8:00 ET on Friday, September 5th.

Where is the Kansas City Chiefs vs. Los Angeles Chargers Game Being Played?

This game is going to be played at Corinthians Arena in Sao Paulo, Brazil.

How Can I Watch Kansas City vs. Los Angeles?

You can watch Chiefs vs. Chargers on Youtube.

Can the Chargers beat the Chiefs?

Of course! Although the Chiefs have won seven straight matchups against the Chargers, these have been highly contested matchups, where KC has won six of them by seven points or less. The spread is just a field goal so the oddsmakers think this should be a tight one.

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Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
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