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Featured Last Updated Sep 19 2025, 9:49 AM

Kansas City Chiefs vs. New York Giants Week 3 Prediction: Odds, Best Bet

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
8 minute read
Kansas City Chiefs vs. New York Giants Week 3 Prediction: Odds, Best Bet

Kansas City Chiefs vs. New York Giants Odds, NFL Week 3

Image Credit: Jay Biggerstaff-Imagn Images

KC @ NYG Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Kansas City Chiefs 477 Chiefs
-6.5 -110 -3.5 -105 + -3.5 -110 + -3.5 -102 + -3.5 -105 + -3.5 -105 -3.5 -105 + -2.5 -125 -3.5 even + -3.5 even -6 -110  
New York Giants 478 Giants
+6.5 -110 +3.5 -115 + +3.5 -110 + +3.5 -118 + +3.5 -115 + +3.5 -125 +3.5 -115 + +2.5 +105 +3.5 -122 + +3.5 -122 +6 -110  
Kansas City Chiefs 477 Chiefs
o43.5 -110 o22.5 -115 + N/A o22.5 -115 + o22.5 -115 + N/A o23.5 +105 + o22.5 -125 o22.5 -121 + o22.5 -121 o45.5 -108  
New York Giants 478 Giants
u43.5 -110 u22.5 -105 + N/A u22.5 -105 + u22.5 -105 + N/A u23.5 -125 + u22.5 +105 u22.5 -103 + u22.5 -103 u45.5 -112  
Kansas City Chiefs 477 Chiefs
-285 -205 + N/A -198 + -205 + -200 -205 + -190 -200 + -200 -325  
New York Giants 478 Giants
+230 +170 + N/A +164 + +170 + +150 +164 + +160 +160 + +160 +260  
Kansas City Chiefs 477 Chiefs
-6.5 -110 -0.5 even + -0.5 -102 + -0.5 +105 + -0.5 even + N/A -1.5 +106 + -0.5 -110 -1.5 +107 + -1.5 +107 -6 -110  
New York Giants 478 Giants
+6.5 -110 +0.5 -120 + +0.5 -125 + +0.5 -125 + +0.5 -130 + N/A +1.5 -128 + +0.5 -120 +1.5 -134 + +1.5 -134 +6 -110  
Kansas City Chiefs 477 Chiefs
o43.5 -110 o7.5 +105 + N/A o7.5 +105 + o7.5 even + N/A o7.5 -106 + o8.5 -130 o8.5 -112 + o8.5 -112 o45.5 -108  
New York Giants 478 Giants
u43.5 -110 u7.5 -125 + N/A u7.5 -125 + u7.5 -130 + N/A u7.5 -116 + u8.5 -105 u8.5 -112 + u8.5 -112 u45.5 -112  
Kansas City Chiefs 477 Chiefs
-285 -170 + N/A -166 + -170 + N/A -170 + -175 -167 + -167 -325  
New York Giants 478 Giants
+230 +145 + N/A +140 + +140 + N/A +138 + +135 +133 + +133 +260  
Kansas City Chiefs 477 Chiefs
-6.5 -110 N/A N/A -2.5 -110 + -2.5 -110 + N/A -2.5 -112 + N/A N/A N/A -6 -110  
New York Giants 478 Giants
+6.5 -110 N/A N/A +2.5 -110 + +2.5 -110 + N/A +2.5 -108 + N/A N/A N/A +6 -110  
Kansas City Chiefs 477 Chiefs
o43.5 -110 o13 -115 + N/A o13.5 -108 + o13.5 -110 + N/A o13.5 -122 + N/A N/A N/A o45.5 -108  
New York Giants 478 Giants
u43.5 -110 u13 -105 + N/A u13.5 -112 + u13.5 -110 + N/A u13.5 -100 + N/A N/A N/A u45.5 -112  
Kansas City Chiefs 477 Chiefs
-285 -190 + N/A -180 + -170 + N/A -180 + N/A N/A N/A -325  
New York Giants 478 Giants
+230 +160 + N/A +150 + +140 + N/A +146 + N/A N/A N/A +260  
Kansas City Chiefs 477 Chiefs
-6.5 -110 N/A N/A -1.5 -105 + -1.5 -110 + N/A -1.5 +102 + N/A N/A N/A -6 -110  
New York Giants 478 Giants
+6.5 -110 N/A N/A +1.5 -115 + +1.5 -110 + N/A +1.5 -124 + N/A N/A N/A +6 -110  
Kansas City Chiefs 477 Chiefs
o43.5 -110 o9.5 -115 + N/A o9.5 -108 + o9.5 -115 + N/A o9.5 -116 + N/A N/A N/A o45.5 -108  
New York Giants 478 Giants
u43.5 -110 u9.5 -105 + N/A u9.5 -112 + u9.5 -105 + N/A u9.5 -106 + N/A N/A N/A u45.5 -112  
Kansas City Chiefs 477 Chiefs
-285 -170 + N/A -198 + -190 + N/A -172 + N/A N/A N/A -325  
New York Giants 478 Giants
+230 +145 + N/A +164 + +160 + N/A +140 + N/A N/A N/A +260  
Kansas City Chiefs 477 Chiefs
-6.5 -110 -0.5 -105 + N/A -1.5 -108 + -1.5 -110 + N/A -1.5 -100 + N/A N/A N/A -6 -110  
New York Giants 478 Giants
+6.5 -110 +0.5 -115 + N/A +1.5 -112 + +1.5 -110 + N/A +1.5 -122 + N/A N/A N/A +6 -110  
Kansas City Chiefs 477 Chiefs
o43.5 -110 o13 -105 + N/A o12.5 -122 + o13.5 +105 + N/A o12.5 -112 + N/A N/A N/A o45.5 -108  
New York Giants 478 Giants
u43.5 -110 u13 -115 + N/A u12.5 +102 + u13.5 -125 + N/A u12.5 -108 + N/A N/A N/A u45.5 -112  
Kansas City Chiefs 477 Chiefs
-285 -150 + N/A -166 + -170 + N/A -162 + N/A N/A N/A -325  
New York Giants 478 Giants
+230 +125 + N/A +140 + +150 + N/A +130 + N/A N/A N/A +260  
Kansas City Chiefs 477 Chiefs
-6.5 -110 -2.5 -125 + N/A N/A -3.5 even + N/A -2.5 -120 + N/A -2.5 -125 + -2.5 -125 -6 -110  
New York Giants 478 Giants
+6.5 -110 +2.5 +105 + N/A N/A +3.5 -120 + N/A +2.5 -100 + N/A +2.5 +102 + +2.5 +102 +6 -110  
Kansas City Chiefs 477 Chiefs
o43.5 -110 o21.5 -115 + N/A N/A o22.5 -115 + N/A o21.5 -115 + N/A o22.5 -109 + o22.5 -109 o45.5 -108  
New York Giants 478 Giants
u43.5 -110 u21.5 -105 + N/A N/A u22.5 -105 + N/A u21.5 -105 + N/A u22.5 -114 + u22.5 -114 u45.5 -112  
Kansas City Chiefs 477 Chiefs
-285 -190 + N/A N/A N/A N/A -190 + N/A -190 + -190 -325  
New York Giants 478 Giants
+230 +160 + N/A N/A N/A N/A +160 + N/A +150 + +150 +260  

The Chiefs will take on the Giants in this week's NFL action. Kickoff is set for 8:20 p.m. EDT at MetLife Stadium in East Rutherford, N.J. The game will be broadcast live on NBC. Here's everything you need to know about Chiefs vs. Giants odds, the latest NFL spreads, NFL over/unders and more.

The Chiefs opened as a -6 point favorite over Giants. The total is set at over/under 45.5 total points scored by both teams combined.

Be sure to check out the latest NFL Odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

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Kansas City Chiefs vs. New York Giants Best Bet

Russell Wilson went to town against the Cowboys last week, but that's probably not going to happen again here against the Chiefs.

Kansas City has allowed just one completion on eight attempts 20 or more yards down the field to start the year — the third-best rate in the league — and we know Wilson is nothing without his deep ball.

The Chiefs did slow the Eagles' vaunted offense last week, but I feel as though I've spent most of this column bashing Philly.

I don't think this is the best defense in the world, but Kansas City did hold Saquon Barkley in check last week after slamming the door on the Chargers' backfield in Week 1.

Are we going to be overly critical about one tough game against Justin Herbert, who might be growing into the league's best quarterback? I don't think we are.

If they shut down the deep ball and the run just as they've been doing through two weeks, the Chiefs are going to render the Giants' offense ineffective, which should open the door for a big-time statement win.

Let's also remember New York allowed 40 points last week.

Kansas City Chiefs vs. New York Giants Best Bet: Chiefs -5.5

(Pick via Kenny Ducey)


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What Time is the Kansas City Chiefs vs. New York Giants Game?

The Kansas City Chiefs vs. New York Giants play at 8:20 PM ET on Sunday, September 21st.

Where is the Kansas City Chiefs vs. New York Giants Game Being Played?

This game is going to be played at MetLife Stadium in East Rutherford, N.J.

How Can I Watch the Kansas City Chiefs vs. New York Giants?

You can watch Kansas City Chiefs vs. New York Giants on NBC.

Can The Giants Beat The Chiefs?

The Giants are a 6.5 point underdog against the Chiefs. Anything can happen in the NFL!

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 2 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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