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Featured Last Updated Sep 26 2025, 9:54 AM

Indianapolis Colts vs. Los Angeles Rams Week 4 Prediction: Odds, Best Bet

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
8 minute read
Indianapolis Colts vs. Los Angeles Rams Week 4 Prediction: Odds, Best Bet

Indianapolis Colts vs. Los Angeles Rams Odds, NFL Week 4

Image Credit: Andrew Nelles / The Tennessean / USA TODAY NETWORK via Imagn Images

IND @ LA Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Indianapolis Colts 269 Colts
+6.5 -110 +2.5 -105 + +2.5 -110 + +2.5 -108 + +2.5 -105 + +2.5 -110 + +1.5 -110 + +1.5 even +1.5 -112 + +2.5 -110 +3.5 -105  
Los Angeles Rams 270 Rams
-6.5 -110 -2.5 -115 + -2.5 -110 + -2.5 -112 + -2.5 -115 + -2.5 -120 + -1.5 -110 + -1.5 -120 -1.5 -112 + -2.5 -110 -3.5 -115  
Indianapolis Colts 269 Colts
o46.5 -110 o24.5 even + N/A o23.5 -122 + o24.5 even + N/A o24.5 -105 + o24.5 even o24.5 -106 + o24.5 even o49.5 -115  
Los Angeles Rams 270 Rams
u46.5 -110 u24.5 -120 + N/A u23.5 +102 + u24.5 -120 + N/A u24.5 -115 + u24.5 -120 u24.5 -117 + u24.5 -120 u49.5 -105  
Indianapolis Colts 269 Colts
+230 +135 + N/A +136 + +140 + +130 + +122 + +130 +120 + N/A +160  
Los Angeles Rams 270 Rams
-285 -160 + N/A -162 + -165 + -170 + -148 + -160 -150 + N/A -192  
Indianapolis Colts 269 Colts
+6.5 -110 +0.5 -150 + +0.5 -155 + +0.5 -148 + +0.5 -150 + +0.5 -160 + +1.5 -166 + +1.5 -180 +1.5 -155 + +0.5 -150 +3.5 -105  
Los Angeles Rams 270 Rams
-6.5 -110 -0.5 +125 + -0.5 +120 + -0.5 +124 + -0.5 +120 + -0.5 +125 + -1.5 +136 + -1.5 +130 -1.5 +125 + -0.5 +125 -3.5 -115  
Indianapolis Colts 269 Colts
o46.5 -110 o9.5 -120 + N/A o9.5 -115 + o9.5 -125 + o9.5 -125 + o9.5 -116 + o8.5 -150 o9.5 -121 + o9.5 -120 o49.5 -115  
Los Angeles Rams 270 Rams
u46.5 -110 u9.5 even + N/A u9.5 -105 + u9.5 -105 + u9.5 -105 + u9.5 -106 + u8.5 +110 u9.5 -104 + u9.5 even u49.5 -105  
Indianapolis Colts 269 Colts
+230 +105 + N/A +105 + even + -105 + -100 + -105 +105 + N/A +160  
Los Angeles Rams 270 Rams
-285 -125 + N/A -125 + -130 + -125 + -122 + -125 -132 + N/A -192  
Indianapolis Colts 269 Colts
+6.5 -110 +2 -110 + N/A +1.5 -105 + +1.5 -110 + N/A +2.5 -110 + N/A +1.5 -118 + N/A +3.5 -105  
Los Angeles Rams 270 Rams
-6.5 -110 -2 -110 + N/A -1.5 -115 + -1.5 -110 + N/A -2.5 -110 + N/A -1.5 -105 + N/A -3.5 -115  
Indianapolis Colts 269 Colts
o46.5 -110 o24 -110 + N/A o24.5 -108 + o24.5 even + N/A o24.5 -100 + N/A o23.5 -125 + o24.5 -105 o49.5 -115  
Los Angeles Rams 270 Rams
u46.5 -110 u24 -110 + N/A u24.5 -112 + u24.5 -120 + N/A u24.5 -120 + N/A u23.5 even + u24.5 -125 u49.5 -105  
Indianapolis Colts 269 Colts
+230 +120 + N/A +136 + N/A N/A +138 + N/A +123 + N/A +160  
Los Angeles Rams 270 Rams
-285 -140 + N/A -162 + N/A N/A -162 + N/A -157 + N/A -192  
Indianapolis Colts 269 Colts
+6.5 -110 N/A N/A +1.5 -112 + +2.5 -110 + N/A +1.5 -122 + N/A N/A +1.5 -120 +3.5 -105  
Los Angeles Rams 270 Rams
-6.5 -110 N/A N/A -1.5 -108 + -2.5 -110 + N/A -1.5 -100 + N/A N/A -1.5 -110 -3.5 -115  
Indianapolis Colts 269 Colts
o46.5 -110 o14 -105 + N/A o14.5 -102 + o14.5 -105 + N/A o15.5 -114 + N/A N/A o15.5 -115 o49.5 -115  
Los Angeles Rams 270 Rams
u46.5 -110 u14 -115 + N/A u14.5 -118 + u14.5 -115 + N/A u15.5 -108 + N/A N/A u15.5 -115 u49.5 -105  
Indianapolis Colts 269 Colts
+230 +130 + N/A +140 + +140 + N/A +122 + N/A N/A N/A +160  
Los Angeles Rams 270 Rams
-285 -155 + N/A -166 + -165 + N/A -150 + N/A N/A N/A -192  
Indianapolis Colts 269 Colts
+6.5 -110 N/A N/A +0.5 -115 + +0.5 -120 + N/A +1.5 -124 + N/A N/A +0.5 -120 +3.5 -105  
Los Angeles Rams 270 Rams
-6.5 -110 N/A N/A -0.5 -105 + -0.5 even + N/A -1.5 +102 + N/A N/A -0.5 -110 -3.5 -115  
Indianapolis Colts 269 Colts
o46.5 -110 o10 -110 + N/A o10.5 +120 + o10.5 +120 + N/A o9.5 -146 + N/A N/A o9.5 -160 o49.5 -115  
Los Angeles Rams 270 Rams
u46.5 -110 u10 -110 + N/A u10.5 -142 + u10.5 -140 + N/A u9.5 +120 + N/A N/A u9.5 +120 u49.5 -105  
Indianapolis Colts 269 Colts
+230 +120 + N/A +136 + +130 + N/A +138 + N/A N/A N/A +160  
Los Angeles Rams 270 Rams
-285 -140 + N/A -162 + -155 + N/A -170 + N/A N/A N/A -192  
Indianapolis Colts 269 Colts
+6.5 -110 +0.5 -125 + N/A +0.5 -122 + +0.5 -120 + N/A +1.5 -144 + N/A N/A N/A +3.5 -105  
Los Angeles Rams 270 Rams
-6.5 -110 -0.5 +105 + N/A -0.5 +102 + -0.5 even + N/A -1.5 +118 + N/A N/A N/A -3.5 -115  
Indianapolis Colts 269 Colts
o46.5 -110 o14 -110 + N/A o13.5 -122 + o13.5 -120 + N/A o13.5 -116 + N/A N/A o13.5 -115 o49.5 -115  
Los Angeles Rams 270 Rams
u46.5 -110 u14 -110 + N/A u13.5 +102 + u13.5 even + N/A u13.5 -106 + N/A N/A u13.5 -115 u49.5 -105  
Indianapolis Colts 269 Colts
+230 +110 + N/A +110 + +105 + N/A +110 + N/A N/A N/A +160  
Los Angeles Rams 270 Rams
-285 -130 + N/A -130 + -125 + N/A -134 + N/A N/A N/A -192  

The Colts will take on the Rams in this week's NFL action. Kickoff is set for 4:05 p.m. EDT at SoFi Stadium in Inglewood, Calif. The game will be broadcast live on FOX. Here's everything you need to know about Colts vs. Rams odds, the latest NFL spreads, NFL over/unders and more.

The Rams opened as a -3.5 point favorite over Colts. The total is set at over/under 49.5 total points scored by both teams combined.

Be sure to check out the latest NFL Odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 9/26/25

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Indianapolis Colts vs. Los Angeles Rams Best Bet

Jones has thrown for at least 228 yards in every game this season, yet he enters this week as a 3.5-point road underdog with a passing line set at just 214.5. That number feels far too low. Just this past weekend, we watched the Eagles racked up 209 passing yards in the second half alone against the Rams, even when Los Angeles knew the pass was coming. The absence of Alec Pierce isn’t a major blow to the deep passing game, as Adonai Mitchell still provides the explosive play-making ability needed to push Jones comfortably over this line.

Indianapolis Colts vs. Los Angeles Rams Best Bet: Daniel Jones o215.5 Passing Yards (-115)

(Pick via Jordan Vanek)


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What Time is the Indianapolis Colts vs. Los Angeles Rams Game?

The Indianapolis Colts and Los Angeles Rams play at 4:05 PM ET on Sunday, September 28th.

Where is the Indianapolis Colts vs. Los Angeles Rams Game Being Played?

This game is going to be played at SoFi Stadium in Inglewood, CA.

How Can I Watch the Indianapolis Colts vs. Los Angeles Rams?

You can watch Indianapolis Colts vs. Los Angeles Rams on FOX.

Can The Colts Beat The Rams?

The Rams are a 3.5-point favorite against the Colts. Anything can happen in the NFL!

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 2 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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