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Featured Last Updated Sep 19 2025, 9:40 AM

NFL: Colts vs. Titans, Prediction, Odds, Best Bet

Derek Mountain
Derek Mountain Sports Betting Expert
8 minute read
NFL: Colts vs. Titans, Prediction, Odds, Best Bet

Featured Image Credit: Grace Hollars via Imagn Images

IND @ TEN Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Indianapolis Colts 451 Colts
+1.5 -110 -2.5 -115 + -2.5 -115 + -2.5 -118 + -2.5 -115 + -2.5 -120 + -2.5 -120 + -2.5 -115 -2.5 -115 + -2.5 -115 -4.5 -105  
Tennessee Titans 452 Titans
-1.5 -110 +2.5 -105 + +2.5 -105 + +2.5 -102 + +2.5 -103 + +2.5 -110 + +2.5 -100 + +2.5 -105 +2.5 -108 + +2.5 -108 +4.5 -115  
Indianapolis Colts 451 Colts
o45.5 -105 o21.5 -110 + N/A o21.5 -105 + o21.5 -110 + N/A o22.5 -110 + o22.5 -105 o21.5 -112 + o21.5 -112 o43.5 -110  
Tennessee Titans 452 Titans
u45.5 -115 u21.5 -110 + N/A u21.5 -115 + u21.5 -108 + N/A u22.5 -110 + u22.5 -115 u21.5 -112 + u21.5 -112 u43.5 -110  
Indianapolis Colts 451 Colts
+102 -165 + N/A -166 + -169 + -170 + -182 + -170 -175 + -175 -198  
Tennessee Titans 452 Titans
-122 +140 + N/A +140 + +140 + +130 + +146 + +140 +135 + +135 +164  
Indianapolis Colts 451 Colts
+1.5 -110 -0.5 +120 + -0.5 -102 + -0.5 +120 + N/A -0.5 +105 + -1.5 +110 + -0.5 even -1.5 +112 + -1.5 +112 -4.5 -105  
Tennessee Titans 452 Titans
-1.5 -110 +0.5 -140 + +0.5 -125 + +0.5 -142 + N/A +0.5 -135 + +1.5 -136 + +0.5 -135 +1.5 -137 + +1.5 -137 +4.5 -115  
Indianapolis Colts 451 Colts
o45.5 -105 o7.5 +115 + N/A o7.5 +114 + N/A o7.5 +110 + o7.5 +106 + o8.5 -110 o7.5 +102 + o7.5 +102 o43.5 -110  
Tennessee Titans 452 Titans
u45.5 -115 u7.5 -135 + N/A u7.5 -135 + N/A u7.5 -140 + u7.5 -130 + u8.5 -120 u7.5 -127 + u7.5 -127 u43.5 -110  
Indianapolis Colts 451 Colts
+102 -140 + N/A -148 + -160 + -150 + -164 + -160 -165 + -165 -198  
Tennessee Titans 452 Titans
-122 +120 + N/A +124 + +130 + +120 + +134 + +120 +130 + +130 +164  
Indianapolis Colts 451 Colts
+1.5 -110 N/A N/A -2.5 -110 + N/A N/A -1.5 -104 + N/A N/A N/A -4.5 -105  
Tennessee Titans 452 Titans
-1.5 -110 N/A N/A +2.5 -110 + N/A N/A +1.5 -118 + N/A N/A N/A +4.5 -115  
Indianapolis Colts 451 Colts
o45.5 -105 o13 -105 + N/A o13.5 +105 + N/A N/A o13.5 -104 + N/A N/A N/A o43.5 -110  
Tennessee Titans 452 Titans
u45.5 -115 u13 -115 + N/A u13.5 -125 + N/A N/A u13.5 -116 + N/A N/A N/A u43.5 -110  
Indianapolis Colts 451 Colts
+102 -160 + N/A -166 + N/A N/A -160 + N/A N/A N/A -198  
Tennessee Titans 452 Titans
-122 +135 + N/A +140 + N/A N/A +130 + N/A N/A N/A +164  
Indianapolis Colts 451 Colts
+1.5 -110 N/A N/A -0.5 +110 + N/A N/A -1.5 +126 + N/A N/A N/A -4.5 -105  
Tennessee Titans 452 Titans
-1.5 -110 N/A N/A +0.5 -130 + N/A N/A +1.5 -152 + N/A N/A N/A +4.5 -115  
Indianapolis Colts 451 Colts
o45.5 -105 o9.5 -110 + N/A o8.5 -112 + N/A N/A o8.5 -112 + N/A N/A N/A o43.5 -110  
Tennessee Titans 452 Titans
u45.5 -115 u9.5 -110 + N/A u8.5 -108 + N/A N/A u8.5 -108 + N/A N/A N/A u43.5 -110  
Indianapolis Colts 451 Colts
+102 -140 + N/A -142 + N/A N/A -142 + N/A N/A N/A -198  
Tennessee Titans 452 Titans
-122 +120 + N/A +120 + N/A N/A +116 + N/A N/A N/A +164  
Indianapolis Colts 451 Colts
+1.5 -110 -0.5 -105 + N/A -0.5 -115 + N/A N/A -1.5 +114 + N/A N/A N/A -4.5 -105  
Tennessee Titans 452 Titans
-1.5 -110 +0.5 -115 + N/A +0.5 -105 + N/A N/A +1.5 -140 + N/A N/A N/A +4.5 -115  
Indianapolis Colts 451 Colts
o45.5 -105 o12.5 -110 + N/A o12.5 -112 + N/A N/A o11.5 -110 + N/A N/A N/A o43.5 -110  
Tennessee Titans 452 Titans
u45.5 -115 u12.5 -110 + N/A u12.5 -108 + N/A N/A u11.5 -110 + N/A N/A N/A u43.5 -110  
Indianapolis Colts 451 Colts
+102 -150 + N/A -142 + N/A N/A -142 + N/A N/A N/A -198  
Tennessee Titans 452 Titans
-122 +125 + N/A +120 + N/A N/A +116 + N/A N/A N/A +164  
Indianapolis Colts 451 Colts
+1.5 -110 -1.5 -105 + N/A N/A -1.5 -110 + N/A -1.5 -110 + N/A -1.5 -115 + -1.5 -115 -4.5 -105  
Tennessee Titans 452 Titans
-1.5 -110 +1.5 -115 + N/A N/A +1.5 -110 + N/A +1.5 -110 + N/A +1.5 -108 + +1.5 -108 +4.5 -115  
Indianapolis Colts 451 Colts
o45.5 -105 o20.5 -120 + N/A N/A o20.5 -115 + N/A o20.5 -115 + N/A o21.5 -107 + o21.5 -107 o43.5 -110  
Tennessee Titans 452 Titans
u45.5 -115 u20.5 even + N/A N/A u20.5 -105 + N/A u20.5 -105 + N/A u21.5 -117 + u21.5 -117 u43.5 -110  
Indianapolis Colts 451 Colts
+102 -150 + N/A N/A N/A N/A -148 + N/A -157 + -157 -198  
Tennessee Titans 452 Titans
-122 +125 + N/A N/A N/A N/A +126 + N/A +128 + +128 +164  

The Colts will take on the Titans in this week's NFL action. Kickoff is set for 1:00 p.m. EDT at Nissan Stadium in Nashville, Tenn. The game will be broadcast live on CBS. Here's everything you need to know about Colts vs. Titans odds, the latest NFL spreads, NFL over/unders and more.

The Colts opened as a -4.5 point favorite over Titans. The total is set at over/under 43.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

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Indianapolis Colts vs. Tennessee Titans Best Bet

Taylor's current role in the Colts offense appears to be one of the best in the league. He played on 92.5% of snaps in Week 2 in a competitive home win against Denver while dominating one of the best defenses in the league for 165 yards rushing with another 50 yards receiving and a TD.

No other Colts RB touched the ball last week either. In a competitive game, Taylor can project for the highest weekly workload of nearly any RB in the league. The Titans have already given up 3 rushing TDs this year and the 5th-most RB rushing yards. We aren't going to see any better odds than this as kickoff gets closer, so I'm loading up early to win 2 units. I would play this to -140 for 2 units and -150 for a single unit.

Colts vs. Titans Best Bet: Jonathan Taylor Anytime Touchdown

(Pick from Brit Devine)

Looking for more best bets? Check out our free NFL picks and our premium subscription for the best picks!

What Time is the Indianapolis Colts vs. Tennessee Titans Game?

The Indianapolis Colts will take on the Tennessee Titans at 1:00 ET on Sunday, September 21st.

Where is the Indianapolis Colts vs. Tennessee Titans Game Being Played?

This game is going to be played at Nissan Stadium in Nashville, Tennessee.

How Can I Watch Titans vs. Colts?

You can watch Titans vs. Colts on CBS.

Can the Titans Beat the Colts?

With a spread of just 4-4.5 points, the Vegas oddsmakers are certainly expecting a tight one where the Titans could upset the 2-0 Colts.

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Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
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