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Featured Last Updated Sep 26 2025, 10:56 AM

Jacksonville Jaguars vs. San Francisco 49ers Week 4 Prediction: Odds, Best Bet

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
8 minute read
Jacksonville Jaguars vs. San Francisco 49ers Week 4 Prediction: Odds, Best Bet

Jacksonville Jaguars vs. San Francisco 49ers Odds, NFL Week 4

Image Credit: Brett Davis-Imagn Images

JAC @ SF Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Jacksonville Jaguars 267 Jaguars
+5.5 -112 +1.5 -110 + +1.5 -115 + +1.5 -112 + +1.5 -114 + +1.5 -125 + +1.5 -115 + +1.5 -105 +1.5 -115 + +1.5 -115 +3 -105  
San Francisco 49ers 268 49ers
-5.5 -108 -1.5 -110 + -1.5 -105 + -1.5 -108 + -1.5 -107 + -1.5 -105 + -1.5 -105 + -1.5 -115 -1.5 -108 + -1.5 -105 -3 -115  
Jacksonville Jaguars 267 Jaguars
o48.5 -110 o23.5 -105 + N/A o23.5 even + o23.5 -105 + N/A o23.5 -100 + o24.5 +110 o23.5 -112 + o23.5 -110 o46.5 -110  
San Francisco 49ers 268 49ers
u48.5 -110 u23.5 -115 + N/A u23.5 -120 + u23.5 -117 + N/A u23.5 -120 + u24.5 -135 u23.5 -112 + u23.5 -110 u46.5 -110  
Jacksonville Jaguars 267 Jaguars
+180 +125 + N/A +124 + +120 + +115 + +116 + +130 +118 + N/A +140  
San Francisco 49ers 268 49ers
-218 -150 + N/A -148 + -148 + -145 + -140 + -160 -148 + N/A -166  
Jacksonville Jaguars 267 Jaguars
+5.5 -112 +0.5 -150 + +0.5 -160 + +0.5 -155 + N/A +0.5 -150 + +1.5 -160 + +1.5 -155 +1.5 -162 + +0.5 -150 +3 -105  
San Francisco 49ers 268 49ers
-5.5 -108 -0.5 +125 + -0.5 +125 + -0.5 +130 + N/A -0.5 +120 + -1.5 +134 + -1.5 +115 -1.5 +128 + -0.5 +125 -3 -115  
Jacksonville Jaguars 267 Jaguars
o48.5 -110 o8.5 -110 + N/A o8.5 -115 + N/A o7.5 -120 + o7.5 -106 + o8.5 -145 o7.5 -114 + o8.5 -115 o46.5 -110  
San Francisco 49ers 268 49ers
u48.5 -110 u8.5 -110 + N/A u8.5 -105 + N/A u7.5 -110 + u7.5 -116 + u8.5 +105 u7.5 -109 + u8.5 -105 u46.5 -110  
Jacksonville Jaguars 267 Jaguars
+180 +110 + N/A +105 + +110 + even + +106 + +110 +108 + N/A +140  
San Francisco 49ers 268 49ers
-218 -130 + N/A -125 + -140 + -130 + -130 + -145 -134 + N/A -166  
Jacksonville Jaguars 267 Jaguars
+5.5 -112 +1 -110 + N/A +1.5 -115 + +1.5 -110 + N/A +1.5 -115 + N/A +1.5 -120 + N/A +3 -105  
San Francisco 49ers 268 49ers
-5.5 -108 -1 -110 + N/A -1.5 -105 + -1.5 -110 + N/A -1.5 -105 + N/A -1.5 -105 + N/A -3 -115  
Jacksonville Jaguars 267 Jaguars
o48.5 -110 o23.5 -110 + N/A o22.5 -115 + o23.5 -105 + N/A o22.5 -110 + N/A o23.5 -103 + o23.5 -110 o46.5 -110  
San Francisco 49ers 268 49ers
u48.5 -110 u23.5 -110 + N/A u22.5 -105 + u23.5 -115 + N/A u22.5 -110 + N/A u23.5 -122 + u23.5 -120 u46.5 -110  
Jacksonville Jaguars 267 Jaguars
+180 +110 + N/A +120 + N/A N/A +122 + N/A +120 + N/A +140  
San Francisco 49ers 268 49ers
-218 -130 + N/A -142 + N/A N/A -144 + N/A -150 + N/A -166  
Jacksonville Jaguars 267 Jaguars
+5.5 -112 N/A N/A +0.5 -108 + N/A N/A +1.5 -134 + N/A N/A +0.5 -120 +3 -105  
San Francisco 49ers 268 49ers
-5.5 -108 N/A N/A -0.5 -112 + N/A N/A -1.5 +110 + N/A N/A -0.5 -110 -3 -115  
Jacksonville Jaguars 267 Jaguars
o48.5 -110 o13.5 -110 + N/A o13.5 -115 + N/A N/A o13.5 -124 + N/A N/A o14.5 even o46.5 -110  
San Francisco 49ers 268 49ers
u48.5 -110 u13.5 -110 + N/A u13.5 -105 + N/A N/A u13.5 +102 + N/A N/A u14.5 -130 u46.5 -110  
Jacksonville Jaguars 267 Jaguars
+180 +125 + N/A +124 + N/A N/A +114 + N/A N/A N/A +140  
San Francisco 49ers 268 49ers
-218 -150 + N/A -148 + N/A N/A -140 + N/A N/A N/A -166  
Jacksonville Jaguars 267 Jaguars
+5.5 -112 N/A N/A +0.5 -125 + N/A N/A +1.5 -146 + N/A N/A +0.5 -135 +3 -105  
San Francisco 49ers 268 49ers
-5.5 -108 N/A N/A -0.5 +105 + N/A N/A -1.5 +122 + N/A N/A -0.5 +105 -3 -115  
Jacksonville Jaguars 267 Jaguars
o48.5 -110 o10 -105 + N/A o9.5 -118 + N/A N/A o9.5 -118 + N/A N/A o9.5 -130 o46.5 -110  
San Francisco 49ers 268 49ers
u48.5 -110 u10 -115 + N/A u9.5 -102 + N/A N/A u9.5 -104 + N/A N/A u9.5 even u46.5 -110  
Jacksonville Jaguars 267 Jaguars
+180 +115 + N/A +120 + N/A N/A +116 + N/A N/A N/A +140  
San Francisco 49ers 268 49ers
-218 -135 + N/A -142 + N/A N/A -144 + N/A N/A N/A -166  
Jacksonville Jaguars 267 Jaguars
+5.5 -112 +0.5 -130 + N/A +0.5 -125 + N/A N/A +1.5 -150 + N/A N/A +0.5 -110 +3 -105  
San Francisco 49ers 268 49ers
-5.5 -108 -0.5 +110 + N/A -0.5 +105 + N/A N/A -1.5 +122 + N/A N/A -0.5 -120 -3 -115  
Jacksonville Jaguars 267 Jaguars
o48.5 -110 o13.5 -110 + N/A o12.5 -125 + N/A N/A o12.5 -124 + N/A N/A o13.5 -105 o46.5 -110  
San Francisco 49ers 268 49ers
u48.5 -110 u13.5 -110 + N/A u12.5 +105 + N/A N/A u12.5 +102 + N/A N/A u13.5 -125 u46.5 -110  
Jacksonville Jaguars 267 Jaguars
+180 +105 + N/A +105 + N/A N/A +104 + N/A N/A N/A +140  
San Francisco 49ers 268 49ers
-218 -125 + N/A -125 + N/A N/A -128 + N/A N/A N/A -166  

The Jaguars will take on the 49ers in this week's NFL action. Kickoff is set for 4:05 p.m. EDT at Levi's Stadium in Santa Clara, Calif. The game will be broadcast live on FOX. Here's everything you need to know about Jaguars vs. 49ers odds, the latest NFL spreads, NFL over/unders and more.

The 49ers opened as a -3.5 point favorite over Jaguars. The total is set at over/under 46.5 total points scored by both teams combined.

Be sure to check out the latest NFL Odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

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Jacksonville Jaguars vs. San Francisco 49ers Best Bet

I refuse to bet on Mac Jones until he faces a real defense — I will hold firm in my stance here. He's not even completely healthy either — with Brock Purdy returning to practice in a limited capacity, it's not a guarantee Jones plays.

Whatever the case, the 49ers are getting decently lucky — but that all seems like it could be changing.

Nick Bosa suffered a devastating injury in Week 3, as did Ricky Pearsall, who didn't practice on Wednesday and may miss this game. I mean, how many receivers have to go down until we stop acting like this is the same 49ers offense that inflicted fear into opposing defenses?

The Jaguars may be 2-1, but Trevor Lawrence still stinks. Th defense has been the Jags' calling card, and why wouldn't they keep going here with so many question marks surrounding the Niners?

I really don't love the under here with the numbers San Francisco has put up, but it is going to regress in time as this team plays some better defenses.

Jacksonville Jaguars vs. San Francisco 49ers Best Bet: Under 47

(Pick via Kenny Ducey)


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What Time is the Jacksonville Jaguars vs. San Francisco 49ers Game?

The Jacksonville Jaguars and San Francisco 49ers play at 4:05 PM ET on Sunday, September 28th.

Where is the Jacksonville Jaguars vs. San Francisco 49ers Game Being Played?

This game is going to be played at Levi's Stadium in Santa Clara, CA.

How Can I Watch the Jacksonville Jaguars vs. San Francisco 49ers?

You can watch Jacksonville Jaguars vs. San Francisco 49ers on FOX.

Can The 49ers Beat The Jaguars?

The 49ers are a 3.5-point favorite against the Jaguars. Anything can happen in the NFL!

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 2 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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