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Featured Last Updated Dec 12 2025, 7:59 AM

NFL: Colts vs. Seahawks, Prediction, Odds

Derek Mountain
Derek Mountain Sports Betting Expert
8 minute read
NFL: Colts vs. Seahawks, Prediction, Odds

Featured Image Credit: Dale Zanine via Imagn Images

IND @ SEA Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Indianapolis Colts 471 Colts
+3.5 -110 +7.5 -110 + +7.5 -115 + +7.5 -112 + +7.5 -112 + +7.5 -120 + +7.5 -115 + +7.5 -110 + +7.5 -118 + +13.5 even  
Seattle Seahawks 472 Seahawks
-3.5 -110 -7.5 -110 + -7.5 -105 + -7.5 -108 + -7.5 -108 + -7.5 -100 + -7.5 -105 + -7.5 -110 + -7.5 -106 + -13.5 -120  
Indianapolis Colts 471 Colts
o44.5 -110 o21.5 -110 + o22.5 -120 + o20.5 -115 + o21.5 -124 + o22.5 -110 + o22.5 -105 + o22.5 even + o21.5 -115 + o42.5 -108  
Seattle Seahawks 472 Seahawks
u44.5 -110 u21.5 -110 + u22.5 even + u20.5 -105 + u21.5 +102 + u22.5 -110 + u22.5 -115 + u22.5 -120 + u21.5 -108 + u42.5 -112  
Indianapolis Colts 471 Colts
+145 +375 + +360 + +410 + +390 + +380 + N/A +400 + +390 + +700  
Seattle Seahawks 472 Seahawks
-175 -500 + -475 + -575 + -530 + -550 + N/A -550 + -530 + -1100  
Indianapolis Colts 471 Colts
+3.5 -110 +2.5 +115 + +2.5 +115 + +3.5 -130 + N/A +3.5 -128 + +3.5 -125 + +3.5 -120 + +2.5 +112 + +13.5 even  
Seattle Seahawks 472 Seahawks
-3.5 -110 -2.5 -135 + -2.5 -150 + -3.5 +110 + N/A -3.5 +106 + -3.5 +105 + -3.5 even + -2.5 -139 + -13.5 -120  
Indianapolis Colts 471 Colts
o44.5 -110 o7.5 even + o7.5 -110 + o7.5 -102 + N/A o7.5 -106 + o7.5 -105 + o8.5 -110 + o7.5 even + o42.5 -108  
Seattle Seahawks 472 Seahawks
u44.5 -110 u7.5 -120 + u7.5 -118 + u7.5 -118 + N/A u7.5 -116 + u7.5 -115 + u8.5 -120 + u7.5 -122 + u42.5 -112  
Indianapolis Colts 471 Colts
+145 +240 + +220 + +245 + N/A +250 + N/A +240 + +220 + +700  
Seattle Seahawks 472 Seahawks
-175 -300 + -295 + -305 + N/A -325 + N/A -350 + -286 + -1100  
Indianapolis Colts 471 Colts
+3.5 -110 +6 -110 + N/A +6.5 -115 + N/A +6.5 -110 + N/A N/A +6.5 -117 + +13.5 even  
Seattle Seahawks 472 Seahawks
-3.5 -110 -6 -110 + N/A -6.5 -115 + N/A -6.5 -110 + N/A N/A -6.5 -107 + -13.5 -120  
Indianapolis Colts 471 Colts
o44.5 -110 o20 -115 + N/A o20.5 -102 + N/A o20.5 +105 + o20.5 -105 + N/A o19.5 -127 + o42.5 -108  
Seattle Seahawks 472 Seahawks
u44.5 -110 u20 -105 + N/A u20.5 -118 + N/A u20.5 -125 + u20.5 -125 + N/A u19.5 +102 + u42.5 -112  
Indianapolis Colts 471 Colts
+145 +250 + N/A +290 + N/A +320 + N/A N/A +310 + +700  
Seattle Seahawks 472 Seahawks
-175 -310 + N/A -395 + N/A -410 + N/A N/A -420 + -1100  
Indianapolis Colts 471 Colts
+3.5 -110 N/A N/A +4.5 -120 + N/A +4.5 -118 + +4.5 -120 + N/A N/A +13.5 even  
Seattle Seahawks 472 Seahawks
-3.5 -110 N/A N/A -4.5 -110 + N/A -4.5 -104 + -4.5 -110 + N/A N/A -13.5 -120  
Indianapolis Colts 471 Colts
o44.5 -110 o12.5 -115 + N/A o12.5 -135 + N/A o13.5 -110 + o13.5 +110 + N/A N/A o42.5 -108  
Seattle Seahawks 472 Seahawks
u44.5 -110 u12.5 -105 + N/A u12.5 +105 + N/A u13.5 -110 + u13.5 -140 + N/A N/A u42.5 -112  
Indianapolis Colts 471 Colts
+145 +375 + N/A +310 + N/A +285 + N/A N/A N/A +700  
Seattle Seahawks 472 Seahawks
-175 -500 + N/A -425 + N/A -375 + N/A N/A N/A -1100  
Indianapolis Colts 471 Colts
+3.5 -110 N/A N/A +3.5 -135 + N/A +3.5 -130 + +3.5 -135 + N/A N/A +13.5 even  
Seattle Seahawks 472 Seahawks
-3.5 -110 N/A N/A -3.5 +105 + N/A -3.5 +106 + -3.5 +105 + N/A N/A -13.5 -120  
Indianapolis Colts 471 Colts
o44.5 -110 o7.5 -110 + N/A o8.5 -115 + N/A o7.5 -110 + o7.5 -115 + N/A N/A o42.5 -108  
Seattle Seahawks 472 Seahawks
u44.5 -110 u7.5 -110 + N/A u8.5 -115 + N/A u7.5 -110 + u7.5 -115 + N/A N/A u42.5 -112  
Indianapolis Colts 471 Colts
+145 +270 + N/A +220 + N/A +260 + N/A N/A N/A +700  
Seattle Seahawks 472 Seahawks
-175 -340 + N/A -298 + N/A -340 + N/A N/A N/A -1100  
Indianapolis Colts 471 Colts
+3.5 -110 +3 -115 + N/A +3.5 -140 + N/A +2.5 +114 + +3.5 -135 + N/A N/A +13.5 even  
Seattle Seahawks 472 Seahawks
-3.5 -110 -3 -105 + N/A -3.5 +110 + N/A -2.5 -140 + -3.5 +105 + N/A N/A -13.5 -120  
Indianapolis Colts 471 Colts
o44.5 -110 o12 -110 + N/A o10.5 -110 + N/A o10.5 +102 + N/A N/A N/A o42.5 -108  
Seattle Seahawks 472 Seahawks
u44.5 -110 u12 -110 + N/A u10.5 -120 + N/A u10.5 -124 + N/A N/A N/A u42.5 -112  
Indianapolis Colts 471 Colts
+145 +175 + N/A +200 + N/A +210 + N/A N/A N/A +700  
Seattle Seahawks 472 Seahawks
-175 -210 + N/A -260 + N/A -265 + N/A N/A N/A -1100  

The Colts will take on the Seahawks in this week's NFL action. Kickoff is set for 4:25 p.m. EST at Lumen Field in Seattle, Wash. The game will be broadcast live on CBS. Here's everything you need to know about Colts vs. Seahawks odds, the latest NFL spreads, NFL over/unders and more.

The Seahawks opened as a -13.5 point favorite over Colts. The total is set at over/under 42.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 12/12/25

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Indianapolis Colts vs. Seattle Seahawks Best Bet

This line is already rising, and I want to grab it before it gets any higher. Indianapolis just lost Daniel Jones to a season-ending Achilles injury. Riley Leonard relieved Jones, but he's dealing with a knee injury. The team is reportedly bringing in Philip Rivers for a visit. That's a pretty concerning development (with all due respect to the 44-year-old Rivers). This was already going to be a tough spot on the road against one of the toughest defenses in the league. It could get ugly for the Colts.

Colts vs. Seahawks Best Bet: Seattle Seahawks -12.5 (-114)

(Pick from Charlie Wright)

Looking for more best bets? Check out our free NFL picks and our premium subscription for the best picks!

What Time is the Indianapolis Colts vs. Seattle Seahawks Game?

The Indianapolis Colts vs. Seattle Seahawks is at 4:25 PM ET on Sunday, December 14th.

Where is the Indianapolis Colts vs. Seattle Seahawks Game Being Played?

This game will be played at Lumen Field in Seattle, Washington.

How Can I Watch Indianapolis Colts vs. Seattle Seahawks?

You can watch Colts vs. Seahawks on CBS.

Can the Colts Beat the Seahawks?

The Colts will need to play a complete game with their season on the line this Sunday.

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Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
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