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Featured Last Updated Dec 8 2025, 2:26 PM

NFL: Los Angeles Rams vs. Detroit Lions: Prediction, Odds, Preview

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
8 minute read
NFL: Los Angeles Rams vs. Detroit Lions: Prediction, Odds, Preview

Featured Image Credit: Rob Schumacher/The Republic / USA TODAY NETWORK via Imagn Images

DET @ LA Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Detroit Lions 477 Lions
-1.5 -105 N/A N/A N/A +3.5 -115 + +3.5 -115 + N/A +3.5 -125 + N/A +6 -115  
Los Angeles Rams 478 Rams
+1.5 -115 N/A N/A N/A -3.5 -105 + -3.5 -105 + N/A -3.5 +105 + N/A -6 -105  
Detroit Lions 477 Lions
o48.5 -110 N/A N/A N/A o27.5 -105 + o27.5 -100 + N/A o26.5 -120 + N/A o55.5 -108  
Los Angeles Rams 478 Rams
u48.5 -110 N/A N/A N/A u27.5 -115 + u27.5 -120 + N/A u26.5 even + N/A u55.5 -112  
Detroit Lions 477 Lions
-118 N/A N/A N/A +164 + +162 + N/A +150 + N/A +210  
Los Angeles Rams 478 Rams
-102 N/A N/A N/A -200 + -205 + N/A -180 + N/A -258  
Detroit Lions 477 Lions
-1.5 -105 N/A N/A N/A N/A +1.5 -132 + N/A +1.5 -120 + N/A +6 -115  
Los Angeles Rams 478 Rams
+1.5 -115 N/A N/A N/A N/A -1.5 +108 + N/A -1.5 even + N/A -6 -105  
Detroit Lions 477 Lions
o48.5 -110 N/A N/A N/A N/A o10.5 +110 + N/A o10.5 +115 + N/A o55.5 -108  
Los Angeles Rams 478 Rams
u48.5 -110 N/A N/A N/A N/A u10.5 -134 + N/A u10.5 -155 + N/A u55.5 -112  
Detroit Lions 477 Lions
-118 N/A N/A N/A N/A +136 + N/A +135 + N/A +210  
Los Angeles Rams 478 Rams
-102 N/A N/A N/A N/A -168 + N/A -175 + N/A -258  
Detroit Lions 477 Lions
-1.5 -105 N/A N/A N/A N/A +2.5 -105 + N/A N/A N/A +6 -115  
Los Angeles Rams 478 Rams
+1.5 -115 N/A N/A N/A N/A -2.5 -115 + N/A N/A N/A -6 -105  
Detroit Lions 477 Lions
o48.5 -110 N/A N/A N/A N/A o27.5 -100 + N/A N/A N/A o55.5 -108  
Los Angeles Rams 478 Rams
u48.5 -110 N/A N/A N/A N/A u27.5 -120 + N/A N/A N/A u55.5 -112  
Detroit Lions 477 Lions
-118 N/A N/A N/A N/A +152 + N/A N/A N/A +210  
Los Angeles Rams 478 Rams
-102 N/A N/A N/A N/A -180 + N/A N/A N/A -258  
Detroit Lions 477 Lions
-1.5 -105 N/A N/A N/A N/A +2.5 -112 + N/A N/A N/A +6 -115  
Los Angeles Rams 478 Rams
+1.5 -115 N/A N/A N/A N/A -2.5 -108 + N/A N/A N/A -6 -105  
Detroit Lions 477 Lions
o48.5 -110 N/A N/A N/A N/A o16.5 -126 + N/A N/A N/A o55.5 -108  
Los Angeles Rams 478 Rams
u48.5 -110 N/A N/A N/A N/A u16.5 +104 + N/A N/A N/A u55.5 -112  
Detroit Lions 477 Lions
-118 N/A N/A N/A N/A +140 + N/A N/A N/A +210  
Los Angeles Rams 478 Rams
-102 N/A N/A N/A N/A -172 + N/A N/A N/A -258  
Detroit Lions 477 Lions
-1.5 -105 N/A N/A N/A N/A +1.5 -122 + N/A N/A N/A +6 -115  
Los Angeles Rams 478 Rams
+1.5 -115 N/A N/A N/A N/A -1.5 -100 + N/A N/A N/A -6 -105  
Detroit Lions 477 Lions
o48.5 -110 N/A N/A N/A N/A o10.5 -108 + N/A N/A N/A o55.5 -108  
Los Angeles Rams 478 Rams
u48.5 -110 N/A N/A N/A N/A u10.5 -112 + N/A N/A N/A u55.5 -112  
Detroit Lions 477 Lions
-118 N/A N/A N/A N/A +142 + N/A N/A N/A +210  
Los Angeles Rams 478 Rams
-102 N/A N/A N/A N/A -176 + N/A N/A N/A -258  
Detroit Lions 477 Lions
-1.5 -105 N/A N/A N/A N/A +1.5 -136 + N/A N/A N/A +6 -115  
Los Angeles Rams 478 Rams
+1.5 -115 N/A N/A N/A N/A -1.5 +112 + N/A N/A N/A -6 -105  
Detroit Lions 477 Lions
o48.5 -110 N/A N/A N/A N/A o14.5 -116 + N/A N/A N/A o55.5 -108  
Los Angeles Rams 478 Rams
u48.5 -110 N/A N/A N/A N/A u14.5 -106 + N/A N/A N/A u55.5 -112  
Detroit Lions 477 Lions
-118 N/A N/A N/A N/A +114 + N/A N/A N/A +210  
Los Angeles Rams 478 Rams
-102 N/A N/A N/A N/A -140 + N/A N/A N/A -258  

The Lions will take on the Rams in this week's NFL action. Kickoff is set for 4:25 p.m. EST at SoFi Stadium in Inglewood, Calif. The game will be broadcast live on FOX. Here's everything you need to know about Lions vs. Rams odds, the latest NFL spreads, NFL over/unders and more.

The Rams opened as a -5.5 point favorite over Lions. The total is set at over/under 55 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 12/8/25

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Los Angeles Rams vs. Detroit Lions Prediction

The Rams have an offensive edge in this matchup, just barely beating the Lions in both rush and dropback EPA. When you compare these two teams on defense, it is not as close. The Rams rank 2nd in dropback EPA allowed and 3rd in rush EPA allowed.

The Lions find themselves in the middle of the pack in terms of defense, so the advantage is clear. The Rams should strengthen their grip here on the NFC.

Los Angeles Rams vs. Detroit Lions Prediction: Los Angeles Rams -5.5 (-110)

(Pick from Dylan Wilkerson)

Looking for more predictions? Check out our free NFL picks and our premium subscription for the best picks!

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What Time is the Los Angeles Rams vs. Detroit Lions Game?

The Los Angeles Rams vs. Detroit Lions game is at 4:25 PM ET on Sunday, December 14th.

Where is the Los Angeles Rams vs. Detroit Lions Game Being Played?

This game will be played at SoFi Stadium in Inglewood, Calif.

How Can I Watch Los Angeles Rams vs. Detroit Lions?

You can watch Los Angeles Rams vs. Detroit Lions on FOX.

Can the Lions Beat the Rams?

Of course! The Lions are a 5.5 point anything can happen in the NFL!

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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