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Featured Last Updated Dec 22 2025, 11:49 AM

NFL: San Francisco 49ers vs. Chicago Bears: Prediction, Odds, Preview

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
8 minute read
NFL: San Francisco 49ers vs. Chicago Bears: Prediction, Odds, Preview

Featured Image Credit: Cary Edmondson-Imagn Images

CHI @ SF Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Chicago Bears 429 Bears
+3.5 -110 N/A N/A N/A N/A +1.5 -125 N/A N/A N/A +3 -120  
San Francisco 49ers 430 49ers
-3.5 -110 N/A N/A N/A N/A -1.5 +105 N/A N/A N/A -3 even  
Chicago Bears 429 Bears
o46.5 -110 N/A N/A N/A N/A o25.5 -110 N/A N/A N/A o50.5 -105  
San Francisco 49ers 430 49ers
u46.5 -110 N/A N/A N/A N/A u25.5 -110 N/A N/A N/A u50.5 -115  
Chicago Bears 429 Bears
+150 N/A N/A N/A N/A +106 N/A N/A N/A +124  
San Francisco 49ers 430 49ers
-180 N/A N/A N/A N/A -128 N/A N/A N/A -148  
Chicago Bears 429 Bears
+3.5 -110 N/A N/A N/A N/A +1.5 -120 N/A N/A N/A +3 -120  
San Francisco 49ers 430 49ers
-3.5 -110 N/A N/A N/A N/A -1.5 -100 N/A N/A N/A -3 even  
Chicago Bears 429 Bears
o46.5 -110 N/A N/A N/A N/A o24.5 -105 N/A N/A N/A o50.5 -105  
San Francisco 49ers 430 49ers
u46.5 -110 N/A N/A N/A N/A u24.5 -115 N/A N/A N/A u50.5 -115  
Chicago Bears 429 Bears
+150 N/A N/A N/A N/A +116 N/A N/A N/A +124  
San Francisco 49ers 430 49ers
-180 N/A N/A N/A N/A -136 N/A N/A N/A -148  
Chicago Bears 429 Bears
+3.5 -110 N/A N/A N/A N/A +1.5 -178 N/A N/A N/A +3 -120  
San Francisco 49ers 430 49ers
-3.5 -110 N/A N/A N/A N/A -1.5 +146 N/A N/A N/A -3 even  
Chicago Bears 429 Bears
o46.5 -110 N/A N/A N/A N/A o9.5 -132 N/A N/A N/A o50.5 -105  
San Francisco 49ers 430 49ers
u46.5 -110 N/A N/A N/A N/A u9.5 +108 N/A N/A N/A u50.5 -115  
Chicago Bears 429 Bears
+150 N/A N/A N/A N/A -106 N/A N/A N/A +124  
San Francisco 49ers 430 49ers
-180 N/A N/A N/A N/A -114 N/A N/A N/A -148  
Chicago Bears 429 Bears
+3.5 -110 N/A N/A N/A N/A +1.5 -136 N/A N/A N/A +3 -120  
San Francisco 49ers 430 49ers
-3.5 -110 N/A N/A N/A N/A -1.5 +112 N/A N/A N/A -3 even  
Chicago Bears 429 Bears
o46.5 -110 N/A N/A N/A N/A o15.5 -112 N/A N/A N/A o50.5 -105  
San Francisco 49ers 430 49ers
u46.5 -110 N/A N/A N/A N/A u15.5 -108 N/A N/A N/A u50.5 -115  
Chicago Bears 429 Bears
+150 N/A N/A N/A N/A +110 N/A N/A N/A +124  
San Francisco 49ers 430 49ers
-180 N/A N/A N/A N/A -134 N/A N/A N/A -148  
Chicago Bears 429 Bears
+3.5 -110 N/A N/A N/A N/A +1.5 -148 N/A N/A N/A +3 -120  
San Francisco 49ers 430 49ers
-3.5 -110 N/A N/A N/A N/A -1.5 +122 N/A N/A N/A -3 even  
Chicago Bears 429 Bears
o46.5 -110 N/A N/A N/A N/A o9.5 -132 N/A N/A N/A o50.5 -105  
San Francisco 49ers 430 49ers
u46.5 -110 N/A N/A N/A N/A u9.5 +108 N/A N/A N/A u50.5 -115  
Chicago Bears 429 Bears
+150 N/A N/A N/A N/A +116 N/A N/A N/A +124  
San Francisco 49ers 430 49ers
-180 N/A N/A N/A N/A -142 N/A N/A N/A -148  
Chicago Bears 429 Bears
+3.5 -110 N/A N/A N/A N/A +1.5 -154 N/A N/A N/A +3 -120  
San Francisco 49ers 430 49ers
-3.5 -110 N/A N/A N/A N/A -1.5 +126 N/A N/A N/A -3 even  
Chicago Bears 429 Bears
o46.5 -110 N/A N/A N/A N/A o13.5 -128 N/A N/A N/A o50.5 -105  
San Francisco 49ers 430 49ers
u46.5 -110 N/A N/A N/A N/A u13.5 +104 N/A N/A N/A u50.5 -115  
Chicago Bears 429 Bears
+150 N/A N/A N/A N/A -102 N/A N/A N/A +124  
San Francisco 49ers 430 49ers
-180 N/A N/A N/A N/A -120 N/A N/A N/A -148  

The Bears will take on the 49ers in this week's NFL action. Kickoff is set for 8:20 p.m. EST at Levi's Stadium in Santa Clara, Calif. The game will be broadcast live on NBC/Peacock. Here's everything you need to know about Bears vs. 49ers odds, the latest NFL spreads, NFL over/unders and more.

The 49ers opened as a -2.5 point favorite over Bears. The total is set at over/under 50.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

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San Francisco 49ers vs. Chicago Bears Prediction

The 49ers have a lot of things going for them in this matchup. They rank 8th in red-zone touchdown conversion rate, where Chicago ranks 16th. The 49ers rank 2nd in 3rd-down EPA/play, where Chicago ranks 9th. The 49ers are also more efficient at moving the ball through the air, and the rush attacks for these two teams are comparable.

Brock Purdy will be spreading the love early and often in this game, looking to expose a Chicago pass defense that is less than stellar. That will be the winning recipe for the 49ers.

San Francisco 49ers vs. Chicago Bears Prediction: San Francisco 49ers -2.5 (-115)

(Pick from Dylan Wilkerson)

Looking for more predictions? Check out our free NFL picks and our premium subscription for the best picks!

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What Time is the San Francisco 49ers vs. Chicago Bears Game?

The San Francisco 49ers vs. Chicago Bears game is at 8:20 PM ET on Sunday, December 28th.

Where is the San Francisco 49ers vs. Chicago Bears Game Being Played?

This game will be played at Levi's Stadium in Santa Clara, Calif.

How Can I Watch San Francisco 49ers vs. Chicago Bears?

You can watch San Francisco 49ers vs. Chicago Bears on NBC/Peacock.

Can the 49ers Beat the Bears?

Of course! The 49ers are a 2.5 point favorite, so the oddsmakers think they will win. However, anything can happen in the NFL!

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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