NFL Odds Week 10: Broncos vs Bills Lines, Spreads, Betting Trends

Matchup Spread Total Moneyline
Bills vs
-7.5 (-110)
+7.5 (-110)
o47.5 (-105)
u47.5 (-115)

Week 10 of the NFL season concludes with Monday Night Football between the Bills and Broncos. The betting odds see Buffalo as a 7.5-point favorite hoping to bounce back from a road loss at Cincy last week. Coverage begins from Highmark Stadium in Orchard Park on Monday, November 13 at 8:15 p.m. ET on ABC.

Here's everything you need to know about the NFL odds for Week 10 Broncos vs. Bills: the opening lines, spreads, betting trends and more. Stay tuned for more details regarding our ESPN BET promo code as we prepare for the upcoming launch!

Denver Broncos vs Buffalo Bills Odds

  • Opening point spread: Bills -7.5
  • Opening moneyline: Bills -380/Broncos +290
  • Opening total: Over/Under 46 points scored
  • Time: 8:15 p.m. ET Monday (ABC/ESPN)

UPDATE 4:30 P.M. ET WEDNESDAY: Buffalo opened and remains 7.5-point chalk on TwinSpires' NFL Week 10 odds board. Ticket count and money are both in the 2/1 range on the Bills.

"Despite their struggles, the Bills are still a popular bet. The Bills are also the No. 1 teaser choice this week, alongside the Bengals," Lucas said.

TwinSpires' total is up a point to 47, with 63% of tickets/70% of cash on the Over. If you're planning to make a bet, use our Twinspires promo code to get potential bonuses.

UPDATE 11:30 P.M. ET SUNDAY: Buffalo (5-4 SU/3-6 ATS) has alternated SU wins and losses over the past five weeks, while failing to cover in all five games. In the Week 10 Sunday nighter at Cincinnati, the Bills fell 24-18 as 1.5-point road 'dogs.

Denver (3-5 SU/2-5-1 ATS) is coming off a bye after its surprising Week 8 victory over Kansas City. The Broncos, catching 7 points at home, notched a 24-9 win and are on their first two-game SU win streak since Weeks 2 and 3 of the 2022-23 season.

"You watch this [Bills-Bengals] game and tell me you think Buffalo should be a double-digit favorite against anyone," Michaelson said. "Denver is playing way better, and coming off the big win over Kansas City, there's as much belief around the Broncos as there's been all year. We'll still likely need Denver, but I could see some public interest in the Broncos."

Broncos-Bills came off The SuperBook's NFL Week 10 odds board once Bills-Bengals kicked off. Broncos-Bills will go back up Monday morning.

Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 10 Report containing spreads, lines, and trends for every NFL matchup.

Broncos vs Bills Pick, Prediction

Action Network NFL betting expert Brandon Anderson offers this prediction:

Check back soon for picks!

Pick: TBD

For more NFL picks, check out Action Network's NFL Week 10: How to Bet Every Game & Every Team.

The One Stat to Know About Broncos vs Bills

Action Network NFL researcher Evan Abrams offers his top betting stat:

Unders on Monday Night Football are 10-1 in 2023 and 55-28-1 since 2019.

For more NFL betting stats, check out Action Network's NFL Week 10 Betting Trends, Stats, Notes.

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