NFL Odds Week 12: Rams vs Cardinals Lines, Spreads, Betting Trends

Matchup Spread Total Moneyline
Cardinals vs
+2.5 (-102)
-2.5 (-120)
o45.5 (-104)
u45.5 (-118)

Week 12 of the NFL season continues with a matchup between bottom dwellers in the NFC West as the Arizona Cardinals host the Los Angeles Rams. The betting odds see the Cards as short home underdogs after playing a pair of competitive games with Kyler Murray under center. Coverage begins from State Farm Stadium in Glendale on Sunday, November 26 at 4:05 p.m. ET on FOX.

Here's everything you need to know about the NFL odds for Week 12: Rams vs Cardinals lines, spreads, betting trends and more.

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Los Angeles Rams vs Arizona Cardinals Odds

  • Opening point spread: Rams -2
  • Opening moneyline: Rams -110/Cardinals -110
  • Opening total: Over/Under 46.5 points scored
  • Time: 4:05 p.m. ET Sunday (FOX)

UPDATE 3:45 P.M. ET SUNDAY: Shortly before kickoff, the Rams are laying 3 points in DraftKings Sportsbook's NFL odds Week 12 market. Los Angeles opened -1, and the line briefly flipped to Arizona -1/-1.5 midweek.

But the number quickly reverted to Rams -1, and it's since gotten out to the current -3. That said, it's two-way spread play with a lean toward L.A., at 55% of tickets/60% of money on L.A.

The total opened at 46.5, plunged to 44.5 Monday until going to 45 Friday. It then spent some time at 45.5 Saturday, but has been at 45 since Saturday night. The Over is seeing 59% of tickets/64% of money.

UPDATE 6 P.M. ET FRIDAY: This line went from Rams -1 to -1.5 (-105) a couple hours after opening Sunday night at BetMGM. L.A. then backed up to -1 Tuesday, and the line jumped the fence to Arizona -1 for a few hours Wednesday.

On Wednesday night, the line returned to Rams -1, then on Thursday went to -2 on the way to -2.5 this afternoon. Tickets and money are in the 4/1 range on Los Angeles.

The total dropped from 46.5 to 44.5 Monday, then rose to 45.5 this afternoon. Current BetMGM splits aren't available.

UPDATE 10 P.M. ET SUNDAY: Arizona (2-9 SU/6-5 ATS) saw its win streak end at a whopping one game. The Cardinals lost to Houston 21-16, but covered as 5.5-point pups, making them 2-0 ATS since Kyler Murray's return.

Los Angeles (4-6 SU/4-5-1 ATS) overcame a 13-0 first-half deficit to beat Seattle 17-16 as a 2.5-point home favorite.

L.A. is down a half-point to -1.5 on The SuperBook's NFL Week 12 odds board.

Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 12 Report containing spreads, lines, and trends for every NFL matchup.

Rams vs Cardinals Pick, Prediction

Action Network NFL betting expert Brandon Anderson offers this prediction:

Check back soon for picks!

Pick: TBD

For more NFL picks, check out Action Network's NFL Week 12: How to Bet Every Game & Every Team.

The One Stat to Know About Rams vs Cardinals

Action Network NFL researcher Evan Abrams offers his top betting stat:

Check back soon for betting stats!

For more NFL betting stats, check out Action Network's NFL Week 12 Betting Trends, Stats, Notes.

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