NFL Odds Week 13: Colts vs Titans Lines, Spreads, Betting Trends
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Week 13 of the NFL season continues with an AFC South battle between the Indianapolis Colts and Tennessee Titans. The betting odds see Tennessee as a short home underdog coming off losses in three of the last four games. Coverage begins from Nissan Stadium in Nashville on Sunday, December 3 at 1:00 p.m. ET on CBS.
Here's everything you need to know about the NFL odds for Week 13: Colts vs Titans lines, spreads, betting trends and more.
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Indianapolis Colts vs Tennessee Titans Odds

- Opening point spread: Colts -2.5
- Opening moneyline: Colts -135/Titans +115
- Opening total: Over/Under 42 points scored
- Time: 1 p.m. ET Sunday (CBS)
UPDATE 2 P.M. ET FRIDAY: Indy moved from -2 to -2.5 Monday at BetMGM, but by Tuesday afternoon, the Colts were down to -1. The line remains Colts -1 this afternoon on two-way spread play with a lean toward the Titans. Tennessee is drawing 56% of spread bets/52% of spread money.
The total opened at 42.5 and is now 42.5. In between, the number touched 43 a couple times early in the week. The Under is taking 85% of bets/84% of money.
UPDATE 10 P.M. ET SUNDAY: Indianapolis (6-5 SU/7-4 ATS) is on a three-game SU and ATS upswing and is 5-2 ATS in its last seven games. In Week 12, the Colts topped Tampa Bay 27-20 as 2.5-point home favorites.
Tennessee (4-7 SU/5-6 ATS) beat Carolina 17-10 to cash as a 3.5-point home fave. That ended a 1-5 SU and ATS purge for the Titans.
The Colts-Titans total is up a tick tonight to 42.5.
Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 13 Report containing spreads, lines, and trends for every NFL matchup.
Colts vs Titans Pick, Prediction
Action Network NFL betting expert Brandon Anderson offers this prediction:
The Titans defense is a pass funnel, and it's going to be tough to run on them, especially with Taylor out. But Tennessee ranks 30th in Pass Defense DVOA and bleeds huge production to opposing receivers. The Titans have allowed the fifth-most WR receptions, and opposing WR1s have at least six catches in eight of 11 Tennessee games (73%) this season.
Pittman needs one more than that to go over this line, but that shouldn't be a problem considering he's had at least eight catches in eight of 11 games. He's clearly the go-to guy for Gardner Minshew, and there's little reason to expect his receptions to disappear against an opponent that prefers it that way. Pittman already has seven games with at least 11 targets.
Pick: Michael Pittman Over 6.5 Receptions (-115)
For more NFL picks, check out Action Network's NFL Week 13: How to Bet Every Game & Every Team.
The One Stat to Know About Colts vs Titans
Action Network NFL researcher Evan Abrams offers his top betting stat:
Colts: Minshew is 6-11 SU, 7-10 ATS in “toss up” games – a spread of 4 or less.
For more NFL betting stats, check out Action Network's NFL Week 13 Betting Trends, Stats, Notes.
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