NFL Odds Week 2: Chargers vs Titans Lines, Spreads, Betting Trends

Matchup Spread Total Moneyline

NFL odds for Week 2 are on the board and receiving plenty of attention as the regular season gets ready to kick off. The Chargers and Titans meet at Nissan Stadium in Nashville on Sunday, September 17 at 1:00 p.m. ET on CBS.

Here's everything you need to know about the NFL odds for the Week 2 game between the Chargers and Titans: the opening lines, spreads, betting trends and more. Check back regularly for updates.

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Los Angeles Chargers vs Tennessee Titans Odds

  • Opening point spread: Chargers -3
  • Opening moneyline: Chargers -180/Titans +150
  • Opening total: Over/Under 45.5 points scored
  • Time: 1 p.m. ET Sunday (CBS)

UPDATE 10 A.M. ET SUNDAY: Not much has changed at BetMGM since Friday (see below). Los Angeles is still -2.5 (-120), with tickets and money just shy of 2/1 on the Chargers, who won't have running back Austin Ekeler (ankle) today.

The total has been at 45.5 since Thursday, after opening there as well and spending time at 46. The Under is getting 60% of tickets/58% of money.

UPDATE 6 P.M. ET FRIDAY: On Sunday night, BetMGM pegged the Chargers 3-point favorites, and the line spent a few hours Monday at -3.5. But the number was at various iterations of -3 most of the week and is now L.A. -2.5 (-120).

Spread tickets and money are just shy of 2/1 on Los Angeles.

The total bounced around throughout the week, from 45.5 to 46, then down to 45. It's been at 45.5 since Thursday morning, with 60% of tickets on the Under/63% of money on the Over.

UPDATE 11 P.M. ET SUNDAY: Los Angeles (0-1 SU and ATS) played a riveting Week 1 game, but came up short. The Chargers gave up a last-minute touchdown, losing 36-34 as 3-point home favorites against Miami.

Tennessee failed to score a touchdown, with all its points coming on Nick Folk field goals in a 16-15 loss at New Orleans. But the Titans (0-1 SU/1-0 ATS) cashed as 3-point pups.

Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 2 Report containing spreads, lines, and trends for every NFL matchup.

Chargers vs Titans Pick, Prediction

Action Network NFL betting expert Brandon Anderson offers this prediction:

The Chargers showed off a great rushing attack under new OC Kellen Moore in the opener, but the Titans led the league in run defense DVOA last season. Tennessee also ranked 28th against the pass, and the Titans are missing CB Kristian Fuller and S Amani Hooker, so this should set up for a big game for Justin Herbert.

The underdog formula sets up well. The Chargers struggle against the run. Hand the ball off to Derrick Henry all game, keep it close, and let Mike Vrabel work his magic as a great home underdog (60% ATS). Play the spread, not the moneyline, in case the Titans lose another close one.

Pick: Titans +2.5 (-105)

For more NFL Week 2 picks, check out Action Network's NFL Week 2: How to Bet Every Game & Every Team.

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  • Compare the latest NFL Odds from the best sportsbooks before placing a bet on this week's games.
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