NFL Odds Week 2: Colts vs Texans Lines, Spreads, Betting Trends

Matchup Spread Total Moneyline

NFL odds for Week 2 are on the board and receiving plenty of attention as the regular season gets ready to kick off. The Colts and Texans meet at NRG Stadium in Houston on Sunday, September 17 at 1:00 p.m. ET on FOX.

Here's everything you need to know about the NFL odds for the Week 2 game between the Colts and Texans: the opening lines, spreads, betting trends and more. Check back regularly for updates.

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Indianapolis Colts vs Houston Texans Odds

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  • Opening point spread: Houston -2
  • Opening moneyline: Houston -120/Indianapolis even
  • Opening total: Over/Under 40 points scored
  • Time: 1 p.m. ET Sunday (FOX)

UPDATE 10:30 A.M. ET SUNDAY: As noted Friday (see below), this number jumped the fence a couple of times after opening Texans -1.5 at BetMGM. Houston briefly got as high as -2.5 (even) this morning, but it's now Texans -1. Current splits aren't available.

This morning, the total nudged from 39.5 to 40, still down from the 40.5 opener but up from the 38.5 low point. The Under is seeing 57% of tickets, while 69% of money is on the Over.

UPDATE 6:30 P.M. ET FRIDAY: This line jumped the fence a couple times this week at BetMGM. The Texans opened -1.5, the number flipped to Colts -1.5 on Monday, then returned to Texans -1.5 by lunch time Thursday.

Houston is now -1 while taking 56% of early spread bets/65% of early spread money.

The total opened at 40.5, bottomed out at 38.5 Thursday and rebounded to 39.5 today. The Under is netting 60% of bets, while 81% of cash is on the Over.

UPDATE 11 P.M. ET SUNDAY: Indy gave Jacksonville a game much of the way. But the Colts (0-1 SU and ATS) allowed two late TDs in a 31-21 loss getting 3.5 points at home. Houston (0-1 SU and ATS) lost at Baltimore 25-9 as a 9.5-point road 'dog.

Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 2 Report containing spreads, lines, and trends for every NFL matchup.

Colts vs Texans Pick, Prediction

Action Network NFL betting expert Brandon Anderson offers this prediction:

Both teams debuted rookie QBs in Week 1, and Anthony Richardson and C.J. Stroud are now both 0-1. The Texans' injury list is ugly. Houston is missing three offensive linemen and could add stud LT Laremy Tunsil to that mix.

The Texans are also missing both safeties, and Stroud is questionable too. Houston has won only two of the last 10 meetings in this divisional rivalry (2-7-1 SU), though last year's games ended in a tie and a one-point loss.

I went all-in on the Texans this season but can't trust the offense right now with as roughshod as the line looks, and now Stroud is banged up, too. I do still like the defense, though, and DeMeco Ryans could unleash this talented unit and make life difficult for Richardson making his professional road debut.

Houston can win this bet with a dominant defensive performance, but you're also protected if the Texans offense just no shows. Three of the last four matchups have been at 40 or below, and unders went 12-4 in Week 1. Week 2 unders at 40 and below are 47-19-3 to the under (71%) the last two decades.

Pick: Under 39.5 (-110)

For more NFL Week 2 picks, check out Action Network's NFL Week 2: How to Bet Every Game & Every Team.

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