NFL Odds Week 2: Giants vs Cardinals Lines, Spreads, Betting Trends

Matchup Spread Total Moneyline
Cardinals vs
+4.5 (-110)
-4.5 (-110)
o39.5 (-118)
u39.5 (-104)

NFL odds for Week 2 are on the board and receiving plenty of attention as the regular season gets ready to kick off. The Giants and Cardinals meet at State Farm Stadium in Glendale on Sunday, September 17 at 4:05 p.m. ET on FOX.

Here's everything you need to know about the NFL odds for the Week 2 game between the Giants and Cardinals: the opening lines, spreads, betting trends and more. Check back regularly for updates.

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New York Giants vs Arizona Cardinals Odds

The Cardinals head home in Week 2 as an underdog to host the Giants. (Getty)
  • Opening point spread: Giants -5.5
  • Opening moneyline: Giants -220/Cardinals +180
  • Opening total: Over/Under 37.5 points scored
  • Time: 4:05 p.m. Sunday ET (FOX)

UPDATE 6:30 P.M. ET FRIDAY: The Giants went from -4.5 to -5.5 Tuesday at BetMGM, then by Thursday afternoon backed up to -4. Still, spread tickets almost 3/1 and spread money 6/1 on New York.

BetMGM moved the total from 38.5 to 40 by Monday night, then inched to 39.5 Wednesday afternoon. The Under is getting 61% of tickets, while 60% of money is on the Over.

UPDATE 11 P.M. ET SUNDAY: Arizona was the consummate bet-against team on the spread in Week 1, but did the bookmakers a big favor. The Cardinals (0-1 SU/1-0 ATS) lost to Washington 20-16, covering as a 7-point road underdog.

New York could only wish it was as competitive under the Sunday night lights. The Giants (0-1 SU and ATS) got steamrolled 40-0 as 3-point home pups to the Cowboys.

During that Sunday night game, The SuperBook took Giants-Cards off the NFL Week 2 odds board. The game will go back up Monday morning.

Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 2 Report containing spreads, lines, and trends for every NFL matchup.

Giants vs Cardinals Pick, Prediction

Action Network NFL betting expert Brandon Anderson offers this prediction:

The Giants got embarrassed in the Sunday night opener, losing 40-0 to the Cowboys, but this team also went 9-7-1 last year and won a playoff game. New York went 2-5 against playoff teams but 7-1-1 against teams that fell short.

This line is downright insulting. The Giants won a playoff game! This calendar year!! Four points, against the worst team in the league, missing its only good player in Budda Baker?! Come on now.

Brian Daboll is a perfect 6-0 ATS after a loss, and Daniel Jones is 20-10 ATS (67%) in that spot. Teams coming off a shutout loss as an underdog cover 58% of the time, and Week 2 teams coming off a double-digit loss are 36-18-3 ATS (67%) against other opponents since 2012, including 20-4-1 (83%) on the road.

Pick: Giants -4 (-110)

For more NFL Week 2 picks, check out Action Network's NFL Week 2: How to Bet Every Game & Every Team.

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  • Compare the latest NFL Odds from the best sportsbooks before placing a bet on this week's games.
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