NFL Odds Week 4: Cardinals vs 49ers Lines, Spreads, Betting Trends

Patrick Everson Sports Betting Expert

3 minute read

The Week 4 NFL betting odds list the 49ers as enormous home favorites over the Cardinals this Sunday, despite Arizona pulling off an upset victory over Dallas last week. Coverage begins from Levi's Stadium in Santa Clara on Sunday, October 1 at 4:25 p.m. ET on FOX.

Here's everything you need to know about the NFL odds for Week 4 Cardinals vs 49ers: the opening lines, spreads, betting trends and more. Check back regularly for updates.

Arizona Cardinals vs San Francisco 49ers Odds

• Opening point spread: 49ers -14.5
• Opening moneyline: 49ers -1000/Cardinals +600
• Opening total: Over/Under 42 points scored
• Time: 4:25 p.m. ET Sunday (FOX)

UPDATE 2:30 P.M. ET SUNDAY: San Francisco has been pinned to -14 all week at TwinSpires Sportsbook. Arizona, which is 3-0 ATS, is getting 58% of spread bets/57% of spread money.

"Bettors are buying into the Arizona hype and taking the two TDs, expecting the Cardinals to get to 4-0 ATS," Lucas said.

The total opened at 42.5, peaked at 44 and is now 43.5. The Over is drawing 59% of bets/67% of money.

"Sharp play on Over 42.5," Lucas said.

UPDATE 9 P.M. ET WEDNESDAY: Some bettors are starting to take note of Arizona, which was thought to be tanking before the season even began. The Cards are one of just three teams with a perfect 3-0 ATS mark.

TwinSpires Sportsbook opened the Niners -14 and is still there. The Cardinals are attracting 58% of spread tickets/56% of spread money in the early going.

"Bettors are buying into the Arizona hype. Getting 14 points in a divisional matchup is enticing bettors," Lucas said.

TwinSpires' total climbed from 42.5 to 44, with 57% of tickets/73% of dollars on the Over.

UPDATE 10 P.M. ET SUNDAY: After a 3-0 SU start, San Francisco is atop the Super Bowl odds board. In the Week 3 Thursday nighter, the Niners (2-1 ATS) rolled over the beat-up New York Giants 30-12 as 10.5-point home favorites.

Arizona pulled the biggest upset of the season thus far. Catching 11.5 points, the Cardinals (1-2 SU/3-0 ATS) shocked Dallas 28-16.

The Cards-Niners line backed up to -14 about an hour after opening this evening at The SuperBook.

Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 4 Report containing spreads, lines, and trends for every NFL matchup.

Cardinals vs 49ers Pick, Prediction

Action Network NFL betting expert Brandon Anderson offers this prediction:

I won't need to invest much in this game, but every piece of data we have says this line is ridiculously long. The numbers say the Cardinals are playing like a playoff team, and there are all sorts of trends backing long division underdogs and double-digit division dogs, especially on the road and early in the season.

My brain says the Niners roll and end this cute little Cinderella run with a 30-point blowout. But the numbers say +650 is way too long and worth a little nibble. My gut said the Cards were live against the Cowboys last week too and I sat that one out, so I have to get a taste this time.

Pick: Cardinals ML (+650)

For more NFL Week 4 picks, check out Action Network's NFL Week 4: How to Bet Every Game & Every Team.

The One Stat to Know About Cardinals vs 49ers

Action Network NFL researcher Evan Abrams offers his top betting stat:

They will be the first team in the Wild Card era to be a double-digit dog in their fourth game after starting 3-0 ATS. The closest? The 1992 Bucs, who won outright on the road as 9.5-point 'dogs against the Lions to move to 4-0 ATS.

For more NFL Week 4 picks, check out Action Network's NFL Week 4 Betting Trends, Stats, Notes.

Where to place a bet this NFL Season?

• Use our exclusive BetMGM Bonus Code VIBONUS1500 to unlock BetMGM’s welcome offer for new sportsbook users!
• Compare the latest NFL Odds from the best sportsbooks before placing a bet on this week's games.
• Check out the North Carolina Sportsbooks just before they launch legal online sports betting.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson