NFL Odds Week 7: 49ers vs Vikings Lines, Spreads, Betting Trends

Patrick Everson Sports Betting Expert

4 minute read

Week 7 of the NFL season concludes with Monday Night Football in Minneapolis with the 49ers set to visit the Vikings in primetime. The betting odds favor San Francisco by a touchdown as they try to bounce back from their first loss of the year. Coverage begins from U. S. Bank Stadium on Monday, October 23rd, at 8:15 p.m. ET on ABC.

Here's everything you need to know about the NFL odds for Week 7 49ers vs Vikings: the opening lines, spreads, betting trends and more. Check back regularly for updates and use our BetMGM bonus code to get the most out of your action.

San Francisco 49ers vs Minnesota Vikings Odds

• Opening point spread: 49ers -7
• Opening moneyline: 49ers -330/Vikings +260
• Opening total: Over/Under 44.5 points scored
• Time: 8:15 p.m. ET Monday (ABC/ESPN)

UPDATE 3 P.M. ET WEDNESDAY: TwinSpires opened San Fran -7, briefly dipped to -6.5, then returned to -7. The Niners are dinged up, with running back Christian McCaffrey (oblique/ribs), wideout Deebo Samuel shoulder) and left tackle (ankle) all questionable.

However, it appears there's a fair chance all could play Monday night. At the moment, San Francisco is seeing 52% of spread tickets, while 53% of spread money is on Minnesota.

"Good two-way action so far. The 49ers and Seahawks are both being teased a lot, so I expect we'll need the Vikes," Lucas said.

The total crept from 44.5 to 44, with 57% of early tickets/55% of early money on the Under.

UPDATE 11 P.M. ET SUNDAY: Like Philly, San Francisco fell from the ranks of the unbeaten in Week 7. But the Niners' loss was surely more stunning.

San Fran closed as a 9.5-point favorite at Cleveland, which had the unknown PJ Walker at quarterback in place of the injured Deshaun Watson. But the 49ers (5-1 SU/4-2 ATS) gave up two late field goals and missed a final-seconds field-goal attempt to fall 19-17.

Adding injury to insult, 49ers running back Christian McCaffrey (oblique) and wideout Deebo Samuel (shoulder) were banged up in Sunday's loss.

With the Niners and Eagles losing, there are no NFL teams with a perfect SU record. San Fran had its regular-season SU win streak snapped at 15, a stretch in which the Niners went 12-3 ATS.

Meanwhile, Minnesota (2-4 SU/2-3-1 ATS) topped Chicago 19-13 giving 3 points on the road.

"The lookahead closed 49ers -7.5, but this line had to go down due to all the uncertainty with injuries for San Francisco's offense," Michaelson said of Niners-Vikings opening -7. "A road loss in bad weather to a really good Browns defense is excusable. But the 49ers can't lay more than a TD until we know about the health of the team.

"Minnesota didn't look great today. I think this line is simply a reflection of what we don't know in regards to San Fran's health."

Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 7 Report containing spreads, lines, and trends for every NFL matchup.

49ers vs Vikings Pick, Prediction

Action Network NFL betting expert Brandon Anderson offers this prediction:

I'm still awaiting the final injury report on this game before making bets.

This was my Lookahead pick. The Vikings won but looked like garbage against Chicago, but the Niners lost the game and three of its stars. I suspect Christian McCaffrey and/or Deebo Samuel could miss this Monday night game, and Trent Williams could join them if that ankle sprain doesn't sit right.

It's still really hard to see San Francisco losing this, so a teaser looks right. Kirk Cousins is 2-10 SU on Monday night, and the Vikings offense looked awful without Justin Jefferson.

Pick: Lean 49ers -7

For more NFL picks, check out Action Network's NFL Week 7: How to Bet Every Game & Every Team.

The One Stat to Know About 49ers vs Vikings

Action Network NFL researcher Evan Abrams offers his top betting stat:

Over the last 20 years, the over is 83-63-1 (56.8%) in Kirk Cousins starts, making him the second-most profitable quarterback to the over in that span. He’s 34-21-1 to the over since 2020, the most profitable quarterback to the over in that span.

This season, Vikings are actually 5-1 to the under.

For more NFL betting stats, check out Action Network's NFL Week 7 Betting Trends, Stats, Notes.

Where to place a bet this NFL Season?

• Use our exclusive BetMGM Bonus Code VIBONUS1500 to unlock BetMGM’s welcome offer for new sportsbook users!
• Compare the latest NFL Odds from the best sportsbooks before placing a bet on this week's games.
• Check out the North Carolina Sportsbooks just before they launch legal online sports betting.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson