2025 Thursday Night Football Odds: Cowboys vs. Eagles Week 1
Thursday Night Football odds for Week 1 hit the board in a hurry, once the NFL released its 2025-26 regular-season schedule. In fact, some books already have TNF odds up for the entire season.
There's a bundle of eye-catching matchups this season, and Week 1 is no exception, with the Super Bowl champion on the docket.
Check back weekly throughout the season for updates on NFL odds for Thursday Night Football, and use our bet365 bonus code to get the most out of your action
Thursday Night Football Week 1 Odds
Thursday Night Football highlights an NFC East clash to kick off the 2025-26 season. The Philadelphia Eagles look to successfully kick off defense of their Super Bowl title when they host the Dallas Cowboys.
Cowboys @ Eagles Betting Odds
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | ESPNBet | FanDuel | BallyBet | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open |  › |  › |  › |  › |  › |  › |  › |  › |  | ||
 451 Cowboys | +7 -110 | +6.5 -105 | +7 -105 | +7 -110 | +7 -110 | +7 -115 | +6.5 -102 | +7 -117 | +7 -118 | +7 -110 | |
 452 Eagles | -7 -110 | -6.5 -115 | -7 -115 | -7 -110 | -7 -110 | -7 -105 | -6.5 -120 | -7 -105 | -7 -106 | -7 -110 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 451 Cowboys | o46.5 -110 | o46.5 -110 | o46.5 -115 | o46.5 -110 | o47 -110 | o46.5 -115 | o46.5 -115 | o46.5 -110 | o46.5 -112 | o46.5 -110 | |
| 452 Eagles | u46.5 -110 | u46.5 -110 | u46.5 -105 | u46.5 -110 | u47 -110 | u46.5 -105 | u46.5 -105 | u46.5 -110 | u46.5 -112 | u46.5 -110 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 451 Cowboys | +240 | +250 | +260 | +260 | +260 | +240 | +265 | +250 | +240 | +260 | |
| 452 Eagles | -298 | -310 | -325 | -325 | -335 | -290 | -330 | -315 | -315 | -325 | |
NFL Thursday Night Football 2025 Schedule & How To Watch
| 🗓️ Week | 📆 Date | 🏈 Matchup | ⌚ Time (ET) | 📡 Coverage |
|---|---|---|---|---|
| 1 | Sept. 4 | Dallas Cowboys vs. Philadelphia Eagles (-7) | 8:20 p.m. | NBC |
| 2 | Sept. 11 | Washington Commanders vs. Green Bay Packers (-1.5) | 8:15 p.m. | Prime Video |
| 3 | Sept. 18 | Miami Dolphins vs. Buffalo Bills (-8.5) | 8:15 p.m. | Prime Video |
| 4 | Sept. 25 | Seattle Seahawks vs. Arizona Cardinals (-2.5) | 8:15 p.m. | Prime Video |
| 5 | Oct. 2 | San Francisco 49ers vs. Los Angeles Rams (-1.5) | 8:15 p.m. | Prime Video |
| 6 | Oct. 9 | Philadelphia Eagles (-7) vs. New York Giants | 8:15 p.m. | Prime Video |
| 7 | Oct. 16 | Pittsburgh Steelers vs. Cincinnati Bengals (-4.5) | 8:15 p.m. | Prime Video |
| 8 | Oct. 23 | Minnesota Vikings vs. Los Angeles Chargers (-3) | 8:15 p.m. | Prime Video |
| 9 | Oct. 30 | Baltimore Ravens (-5.5) vs. Miami Dolphins | 8:15 p.m. | Prime Video |
| 10 | Nov. 6 | Las Vegas Raiders vs. Denver Broncos (-6.5) | 8:15 p.m. | Prime Video |
| 11 | Nov. 13 | New York Jets vs. New England Patriots (-5.5) | 8:15 p.m. | Prime Video |
| 12 | Nov. 20 | Buffalo Bills (-3.5) vs. Houston Texans | 8:15 p.m. | NBC |
| 13 | Nov. 28* | Chicago Bears vs. Philadelphia Eagles (-7) | 3 p.m. | Prime Video |
| 14 | Dec. 4 | Dallas Cowboys vs. Detroit Lions (-6) | 8:15 p.m. | Prime Video |
| 15 | Dec. 11 | Atlanta Falcons vs. Tampa Bay Buccaneers (-5.5) | 8:15 p.m. | Prime Video |
| 16 | Dec. 18 | Los Angeles Rams (-1.5) vs. Seattle Seahawks | 8:15 p.m. | Prime Video |
| 17 | Dec. 25 | Denver Broncos vs. Kansas City Chiefs (-5.5) | 8:15 p.m. | Prime Video |
*Friday edition of Thursday Night Football
Thursday Night Football has been an up-and-down adventure ride since its debut in 2006. Its novelty wore off quickly, as the schedule bounced around between broadcast outlets. There was a few-years stretch in which the matchups always seemed to be ugly football.
Sometimes, late-season matchups that looked great on paper – when the schedule first came out – ended up with two terrible teams.
At the moment, in late May, the quality of the 2025 Thursday Night Football schedule looks great. That are quite a few good divisional matchups, and others such as Commanders vs. Packers that will surely attract a lot of attention.
The season-opening contest in Thursday Night Football odds, between the Eagles and Cowboys, airs on NBC. Every other week, the matchup is on Amazon's Prime Video.
One thing for certain: With TNF on the schedule, Thursday mornings are a little better for sports bettors. It heralds the arrival of the NFL week, another chance to beat the house with all the sports betting tips you find on VegasInsider. No matter what matchups the schedule provides, there’s an angle you can find to cash some tickets.
Other Ways to Bet on Thursday Night Football
One wager that’s always exciting is which player will score the first touchdown of the game. There's usually only one contest on the schedule, though there are a few doubleheaders this season.
Still, there's not a bunch of games to bounce around to, which makes playing that first TD proposition more fun, especially when you cash.
Single-game parlays make up more of the action when there's only one game on TV. Props that correlate together, including who will score, number of receptions and yards rushing, can all be combined on one ticket, dramatically increasing the odds payoff if the parlay hits.
Of course, as with all parlays, if even one play loses, the entire ticket is trashed. Make sure to use our parlay calculator before placing your bets.
TNF Betting Tips
How many times have you seen someone lose their weekly contest because they never entered their pick for Thursday Night Football? Whether it’s a fantasy lineup, an ATS contest or just a pick 'em pool, sometimes life gets in the way of sports betting. Always get your plays locked and loaded early to begin the week.
Going blank on Thursday, the start of that week’s journey towards profitability, can blow up your entire weekend.
That said, you shouldn't let TNF – or any standalone game – make you feel as if you must make a bet. As with Monday Night Football odds, just because there’s a game on doesn’t mean you have to bet it. And if a good spot becomes available in-game, most books have enough live-action options that you can hop on then.
We’ve all seen a tale of two halves. These are games where each half has a completely different outcome. Maybe it’s 6-3 at the break, and both teams combine for 31 points in the second half. Or a team down double digits at halftime ends up winning the game by that much. Betting only the first or second half is a great way to minimize your investment and risk, in any Thursday Night Football game.
Thursday Night Football FAQ
When does Thursday Night Football start?
Thursday Night Football returns for the 2025 season on Sept. 4.
How can I watch Thursday Night Football?
The Week 1 Cowboys vs. Eagles showdown will again be on NBC. From there, all action involving Thursday Night Football odds will again be on Amazon's Prime Video.
One note: Prime won't have a Thanksgiving Day game, but rather will have the Black Friday matchup between the Chicago Bears and Philadelphia Eagles, in a special 3 p.m. ET kickoff.
What is the highest-scoring Thursday Night Football game of all time?
If you like betting Overs, there have been some great TNF matchups in the past. The record for the highest-scoring Thursday Night Football game was set in a 2023 Week 15 contest. The Raiders destroyed the Chargers 63-21, as the two teams combined for 84 points.
Who are the favorites to win the NFL Championship?
The Eagles, Ravens, Bills and Chiefs are the favorites to win this year’s NFL title.
What’s A Good Source For The Best NFL Picks?
You don’t even have to leave this site to find the best NFL handicappers. Check out all the VegasInsider pages for great tips, sports betting advice and some of the best handicappers on the planet.
You can also sign up for VegasInsider Premium, where our experts give more than 1,000 picks per month!