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Packers vs 49ers Prediction, Picks, Odds | NFL Divisional Playoff Game

Michael Crosson
Michael Crosson Sports Betting Expert
5 minute read

Here's everything you need to know about the Packers vs 49ers Picks, Predictions, and Odds for this NFL Divisional Round Game.

The second round of the NFL Playoffs continues on Saturday night with a matchup between the top and bottom seeds in the NFC as the Green Bay Packers take on the San Francisco 49ers. Coverage begins from Levi’s Stadium in Santa Clara at 8:15 p.m. ET on FOX.

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Packers vs 49ers Betting Prediction & Odds for NFL Divisional Playoff Game

Matchup Spread Total Moneyline

On a personal note: I officially wrote off the Packers following their 17-13 loss to the Raiders back in Week 5 – and for a little while, I felt vindicated in my decision as Green Bay stumbled out to a frustrating 3-6 start to the season, while scoring 20 points or less in seven of those nine contests.

However, this young Green Bay team has quickly blossomed before our very eyes. After falling short of the 20-point mark in seven of nine contests to open their campaign, the Packers averaged over 25 PPG across a 6-2 run to close the regular season – and they solidified their claim to fame with a dominant 48-point performance in a road playoff win over Dallas last week.

That said, the oddsmakers seem to think the Packers’ fairytale run is destined to come to a screeching halt in the Divisional Round. According to VegasInsider’s Patrick Everson, the SuperBook opened the spread for this contest at 49ers -9.5, and it has held there at most shops with Patrick noting that the books would like to keep that number above the key line of -8.5 to fend off teasers, if possible. 

While I agree with the oddsmakers to a certain extent, I also believe the Packers aren’t receiving enough credit for the heights they’ve reached recently, especially on the offensive side of the ball. I’m somewhat wary of taking the points with Green Bay due to a lopsided matchup between the 49ers offense and Packers defense. San Francisco might score 40-plus points in this game, and if that happens, the 49ers will almost certainly cover the spread.

However, I do expect the Packers offense to show up and stake their claim against SF’s third-ranked scoring defense, despite drawing their toughest task of the season in this matchup. This young Packers team fears nobody, and they reminded us of their fearless mentality in stunning fashion last week by building a 41-16 lead over Dallas in the third quarter of a road playoff game.

All that taken into account. I’m still not sure if Green Bay’s defense has enough juice to win this game. I’m not even sure if they have enough juice to cover the spread. But any way you slice it, I think we’re going to see Jordan Love and the Packers offense sling the ball around the yard and score more than 20 points in this contest.

Score Prediction: 49ers 34, Packers 26
Best Bet: Packers Team Total Over 20.5 Points (+105)

GB @ SF Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Final
Green Bay Packers 303 Packers
+9.5 -104 +6.5 -110 +6.5 -100 +6.5 -105 +6.5 -105 +5.5 -108 +4.5 -110 +5.5 -104 +10.5 -110  
San Francisco 49ers 304 49ers
-9.5 -118 -6.5 -110 -6.5 -120 -6.5 -115 -6.5 -115 -5.5 -112 -4.5 -110 -5.5 -121 -10.5 -110  
Final
Green Bay Packers 303 Packers
o49.5 -110 o24.5 -115 o25.5 -110 N/A o24.5 -115 o25.5 -110 o25.5 -110 o24.5 -108 o50.5 -115  
San Francisco 49ers 304 49ers
u49.5 -110 u24.5 -105 u25.5 -110 N/A u24.5 -105 u25.5 -110 u25.5 -110 u24.5 -115 u50.5 -105  
Final
Green Bay Packers 303 Packers
+385 +240 +250 +240 +250 +220 N/A +235 +410  
San Francisco 49ers 304 49ers
-500 -300 -320 -300 -320 -270 N/A -315 -550  
Final
Green Bay Packers 303 Packers
+9.5 -104 +4.5 -110 +5.5 -100 N/A +4.5 -110 N/A +5.5 -110 +5.5 -108 +10.5 -110  
San Francisco 49ers 304 49ers
-9.5 -118 -4.5 -110 -5.5 -120 N/A -4.5 -110 N/A -5.5 -120 -5.5 -115 -10.5 -110  
Final
Green Bay Packers 303 Packers
o49.5 -110 o24.5 -105 o24.5 -100 N/A o24.5 even N/A o24.5 -115 o24.5 -112 o50.5 -115  
San Francisco 49ers 304 49ers
u49.5 -110 u24.5 -115 u24.5 -120 N/A u24.5 -120 N/A u24.5 -115 u24.5 -112 u50.5 -105  
Final
Green Bay Packers 303 Packers
+385 +200 +235 N/A N/A N/A N/A +225 +410  
San Francisco 49ers 304 49ers
-500 -245 -290 N/A N/A N/A N/A -295 -550  
Final
Green Bay Packers 303 Packers
+9.5 -104 +2.5 -110 +2.5 -100 +2.5 -110 +2.5 +105 +2.5 even +0.5 -140 +1.5 -115 +10.5 -110  
San Francisco 49ers 304 49ers
-9.5 -118 -2.5 -110 -2.5 -122 -2.5 -120 -2.5 -125 -2.5 -120 -0.5 +115 -1.5 -108 -10.5 -110  
Final
Green Bay Packers 303 Packers
o49.5 -110 o9.5 -140 o9.5 -128 N/A o9.5 -140 o9.5 -135 o9.5 -120 o9.5 -117 o50.5 -115  
San Francisco 49ers 304 49ers
u49.5 -110 u9.5 +120 u9.5 +106 N/A u9.5 +118 u9.5 +114 u9.5 even u9.5 -107 u50.5 -105  
Final
Green Bay Packers 303 Packers
+385 +160 +168 +150 +158 +170 N/A +143 +410  
San Francisco 49ers 304 49ers
-500 -190 -210 -200 -190 -205 N/A -177 -550  
Final
Green Bay Packers 303 Packers
+9.5 -104 +3.5 -110 +3.5 -102 N/A N/A +6.5 +124 +3.5 even +3.5 -108 +10.5 -110  
San Francisco 49ers 304 49ers
-9.5 -118 -3.5 -110 -3.5 -120 N/A N/A -6.5 -160 -3.5 -130 -3.5 -115 -10.5 -110  
Final
Green Bay Packers 303 Packers
o49.5 -110 o14.5 -115 o17.5 +118 N/A N/A o16.5 -115 o16.5 -105 o15.5 -124 o50.5 -115  
San Francisco 49ers 304 49ers
u49.5 -110 u14.5 -105 u17.5 -158 N/A N/A u16.5 -115 u16.5 -125 u15.5 even u50.5 -105  
Final
Green Bay Packers 303 Packers
+385 +200 +205 N/A N/A +195 N/A +200 +410  
San Francisco 49ers 304 49ers
-500 -245 -260 N/A N/A -238 N/A -265 -550  
Final
Green Bay Packers 303 Packers
+9.5 -104 +3 even +3.5 -118 N/A N/A +3.5 -122 +5.5 -115 +3.5 -122 +10.5 -110  
San Francisco 49ers 304 49ers
-9.5 -118 -3 -120 -3.5 -104 N/A N/A -3.5 +102 -5.5 -115 -3.5 -103 -10.5 -110  
Final
Green Bay Packers 303 Packers
o49.5 -110 o9.5 -150 o12.5 -126 N/A N/A o9.5 -155 o10.5 even o10.5 +104 o50.5 -115  
San Francisco 49ers 304 49ers
u49.5 -110 u9.5 +125 u12.5 -106 N/A N/A u9.5 +130 u10.5 -130 u10.5 -129 u50.5 -105  
Final
Green Bay Packers 303 Packers
+385 +220 +198 N/A N/A +215 N/A +210 +410  
San Francisco 49ers 304 49ers
-500 -270 -250 N/A N/A -265 N/A -286 -550  
Final
Green Bay Packers 303 Packers
+9.5 -104 +2.5 -110 +2.5 -110 N/A N/A +2.5 -105 +2.5 -120 +2.5 -106 +10.5 -110  
San Francisco 49ers 304 49ers
-9.5 -118 -2.5 -110 -2.5 -110 N/A N/A -2.5 -115 -2.5 -110 -2.5 -117 -10.5 -110  
Final
Green Bay Packers 303 Packers
o49.5 -110 o13.5 -120 o13.5 -126 N/A N/A o13.5 -122 o13.5 -130 o13.5 -115 o50.5 -115  
San Francisco 49ers 304 49ers
u49.5 -110 u13.5 even u13.5 +104 N/A N/A u13.5 +102 u13.5 even u13.5 -108 u50.5 -105  
Final
Green Bay Packers 303 Packers
+385 +160 +148 N/A N/A +160 N/A +155 +410  
San Francisco 49ers 304 49ers
-500 -190 -184 N/A N/A -192 N/A -195 -550  

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Packers vs 49ers Betting Resources

Date: Saturday, January 20
Matchup: NFC North vs NFC West
Venue: Levi's Stadium
Location: Santa Clara, California
Time-TV: FOX, 8:15 p.m. ET

Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Divisional Playoff Round Report containing spreads, lines, and trends for every NFL matchup.

Use our BetMGM bonus code before making your Packers vs 49ers pick to get bonus bets!

Green Bay Packers Betting Analysis

This is arguably Love’s toughest task yet as Green Bay faces a 49ers secondary that ranks fifth in yards allowed per pass attempt. But at this point, I trust the Packers offense to perform at a modest level against pretty much anybody.

Love has cleared the 250-yard passing mark in eight of the Packers’ last 10 games – with seven of those performances soaring over 265 yards, and four of them climbing up to 280-plus yards. I think we’ll see him perform again here, regardless of opposing defensive strength.

Check out our Super Bowl odds for a preview of the teams likely to be in the big game.

San Francisco 49ers Betting Analysis

Not too long ago, it seemed like Brock Purdy was destined to win MVP. The 49ers boasted an NFL-best record of 11-4 with just three games left in the regular season, and the only question was whether one of Purdy’s teammates would steal the award from him as the QB ranked top-three in almost every major passing efficiency category, but RB Christian McCaffrey also had a legitimate claim to the throne in the eyes of some people.

Well, the countless hours of debate was all for nothing. In Week 16, Purdy completed just 56% of his passes and threw four interceptions in an ugly 33-19 loss to Baltimore – bringing the Purdy MVP conversations to a screeching halt as Ravens QB Lamar Jackson immediately took the reins and closed the regular season as a -8000 favorite at bet365.

Make no mistake about it though. Running backs don’t enter the MVP conversation simply because they are the most productive player on the best offense in the league. It takes a special kind of campaign in order to receive such a high level of praise, and in his first full season since San Francisco, Christian McCaffrey has been a dream come true for the 49ers offense.

Packers vs 49ers Betting Trends

  • The Packers are 6-3 ATS in their last nine games.
  • The total has gone OVER in five of SF's last seven games.
  • The 49ers are 7-2 SU in their last nine games.
  • The total has gone OVER in seven of GB's last eight games.
  • The Packers are 4-1 SU in their last five games.

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Michael Crosson

Michael Crosson

Michael Crosson began his time at VegasInsider as a freelance NBA writer back in 2019 while he continued to study Psychology and Biology at James Madison University. Following his graduation in 2021, Michael joined the team full-time, and he's been with VI ever since. Michael still writes NBA, NFL, and MLB for VI, as well as gambling industry news. He's also become a crucial part of our editorial production team. More from Michael Crosson
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