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Featured Last Updated Oct 2 2025, 11:54 AM

NFL: Raiders vs. Colts, Prediction, Odds, Best Bet

Derek Mountain
Derek Mountain Sports Betting Expert
8 minute read
NFL: Raiders vs. Colts, Prediction, Odds, Best Bet

Featured Image Credit: Jayne Kamin-Oncea via Imagn Images

LV @ IND Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Las Vegas Raiders 467 Raiders
+1.5 -110 +4 -110 + +3.5 -102 + +3.5 +102 + +3.5 even + +3.5 -105 + +4.5 -110 + +4.5 -115 + +3.5 +105 +3.5 even + +7 -115  
Indianapolis Colts 468 Colts
-1.5 -110 -4 -110 + -3.5 -118 + -3.5 -122 + -3.5 -125 + -3.5 -125 + -4.5 -110 + -4.5 -105 + -3.5 -125 -3.5 -122 + -7 -105  
Las Vegas Raiders 467 Raiders
o44.5 -112 o24.5 even + N/A o24.5 -102 + o24.5 -105 + N/A o24.5 +105 + o24.5 -105 + o24.5 even o24.5 -103 + o47.5 -115  
Indianapolis Colts 468 Colts
u44.5 -108 u24.5 -120 + N/A u24.5 -118 + u24.5 -118 + N/A u24.5 -125 + u24.5 -115 + u24.5 -120 u24.5 -122 + u47.5 -105  
Las Vegas Raiders 467 Raiders
+102 +190 + N/A +185 + +190 + +170 + +215 + N/A +185 +185 + +260  
Indianapolis Colts 468 Colts
-122 -230 + N/A -225 + -240 + -240 + -270 + N/A -225 -235 + -310  
Las Vegas Raiders 467 Raiders
+1.5 -110 +2.5 -110 + +0.5 -115 + +2.5 -108 + N/A +1.5 -115 + +2.5 -108 + +2.5 -110 + +1.5 -110 +1.5 -121 + +7 -115  
Indianapolis Colts 468 Colts
-1.5 -110 -2.5 -110 + -0.5 -110 + -2.5 -112 + N/A -1.5 -115 + -2.5 -112 + -2.5 -110 + -1.5 -120 -1.5 -103 + -7 -105  
Las Vegas Raiders 467 Raiders
o44.5 -112 o9.5 -115 + N/A o9.5 -115 + N/A o9.5 -120 + o9.5 -118 + o9.5 -120 + o8.5 -135 o9.5 -136 + o47.5 -115  
Indianapolis Colts 468 Colts
u44.5 -108 u9.5 -105 + N/A u9.5 -105 + N/A u9.5 -110 + u9.5 -104 + u9.5 even + u8.5 even u9.5 +102 + u47.5 -105  
Las Vegas Raiders 467 Raiders
+102 +180 + N/A +180 + N/A +150 + +172 + N/A +165 +145 + +260  
Indianapolis Colts 468 Colts
-122 -220 + N/A -218 + N/A -200 + -215 + N/A -225 -182 + -310  
Las Vegas Raiders 467 Raiders
+1.5 -110 +3.5 -110 + N/A +3.5 -115 + N/A N/A +2.5 -100 + N/A N/A +3.5 -121 + +7 -115  
Indianapolis Colts 468 Colts
-1.5 -110 -3.5 -110 + N/A -3.5 -105 + N/A N/A -2.5 -120 + N/A N/A -3.5 -104 + -7 -105  
Las Vegas Raiders 467 Raiders
o44.5 -112 o23 -110 + N/A o22.5 -115 + N/A N/A o23.5 -110 + o23.5 -105 + N/A o23.5 -114 + o47.5 -115  
Indianapolis Colts 468 Colts
u44.5 -108 u23 -110 + N/A u22.5 -105 + N/A N/A u23.5 -110 + u23.5 -125 + N/A u23.5 -112 + u47.5 -105  
Las Vegas Raiders 467 Raiders
+102 +155 + N/A +170 + N/A N/A +150 + N/A N/A +160 + +260  
Indianapolis Colts 468 Colts
-122 -185 + N/A -198 + N/A N/A -178 + N/A N/A -200 + -310  
Las Vegas Raiders 467 Raiders
+1.5 -110 N/A N/A +2.5 -108 + N/A N/A +2.5 +106 + +2.5 even + N/A N/A +7 -115  
Indianapolis Colts 468 Colts
-1.5 -110 N/A N/A -2.5 -112 + N/A N/A -2.5 -128 + -2.5 -130 + N/A N/A -7 -105  
Las Vegas Raiders 467 Raiders
o44.5 -112 o14 -110 + N/A o15.5 -110 + N/A N/A o14.5 -106 + o15.5 -120 + N/A N/A o47.5 -115  
Indianapolis Colts 468 Colts
u44.5 -108 u14 -110 + N/A u15.5 -110 + N/A N/A u14.5 -116 + u15.5 -110 + N/A N/A u47.5 -105  
Las Vegas Raiders 467 Raiders
+102 +155 + N/A +150 + N/A N/A +172 + N/A N/A N/A +260  
Indianapolis Colts 468 Colts
-122 -185 + N/A -185 + N/A N/A -215 + N/A N/A N/A -310  
Las Vegas Raiders 467 Raiders
+1.5 -110 N/A N/A +0.5 -115 + N/A N/A +1.5 -140 + +0.5 -125 + N/A N/A +7 -115  
Indianapolis Colts 468 Colts
-1.5 -110 N/A N/A -0.5 -105 + N/A N/A -1.5 +116 + -0.5 -105 + N/A N/A -7 -105  
Las Vegas Raiders 467 Raiders
o44.5 -112 o9.5 -120 + N/A o9.5 -122 + N/A N/A o9.5 -134 + o9.5 -135 + N/A N/A o47.5 -115  
Indianapolis Colts 468 Colts
u44.5 -108 u9.5 even + N/A u9.5 +102 + N/A N/A u9.5 +110 + u9.5 +105 + N/A N/A u47.5 -105  
Las Vegas Raiders 467 Raiders
+102 +150 + N/A +140 + N/A N/A +124 + N/A N/A N/A +260  
Indianapolis Colts 468 Colts
-122 -180 + N/A -166 + N/A N/A -152 + N/A N/A N/A -310  
Las Vegas Raiders 467 Raiders
+1.5 -110 +1 -110 + N/A +2.5 -115 + N/A N/A +1.5 -120 + +2.5 even + N/A N/A +7 -115  
Indianapolis Colts 468 Colts
-1.5 -110 -1 -110 + N/A -2.5 -105 + N/A N/A -1.5 -102 + -2.5 -130 + N/A N/A -7 -105  
Las Vegas Raiders 467 Raiders
o44.5 -112 o13.5 -110 + N/A o12.5 -125 + N/A N/A o13.5 -104 + o12.5 -130 + N/A N/A o47.5 -115  
Indianapolis Colts 468 Colts
u44.5 -108 u13.5 -110 + N/A u12.5 +105 + N/A N/A u13.5 -118 + u12.5 even + N/A N/A u47.5 -105  
Las Vegas Raiders 467 Raiders
+102 +140 + N/A +154 + N/A N/A +138 + N/A N/A N/A +260  
Indianapolis Colts 468 Colts
-122 -165 + N/A -185 + N/A N/A -170 + N/A N/A N/A -310  

The Raiders will take on the Colts in this week's NFL action. Kickoff is set for 1:00 p.m. EDT at Lucas Oil Stadium in Indianapolis, Indiana. The game will be broadcast live on FOX. Here's everything you need to know about Raiders vs. Colts odds, the latest NFL spreads, NFL over/unders and more.

The Colts opened as a -7 point favorite over Raiders. The total is set at over/under 47.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

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Las Vegas Raiders vs. Indianapolis Colts Best Bet

It's been a sad slide for my Raiders, who fell to the Bears by one point last week on a missed field goal from 54 yards.

It was supposed to be a breakout game for this scrappy young team, which ran for a whopping 240 yards on 31 carries and rendered Chicago's offense ineffective, but Geno Smith's three interceptions and the missed kick ultimately did it in.

I'm not shying away, however, even with the mighty Colts on the schedule.

Yes, the matchup with the Rams was hard, but in a larger sense it was the first true test they've had after ripping through a few teams that have started in disappointing fashion.

Indy ranks just 17th in DVOA against the run, but it does have the eighth-highest interception rate and seventh-best takeaway rate in the league.

Smith is certainly in trouble, but after what we saw from Ashton Jeanty — and Raheem Mostert, who looked good behind him — I'm a big enough believer in the offense.

Vegas has stopped the run, and while it's 12th-worst in DVOA versus the pass, it's at least held opponents to 6-of-15 passing on deep balls (20+ yards downfield). The Raiders can do enough to neutralize the Colts' offense to draw close.

Raiders vs. Colts Best Bet: Raiders +7

(Pick from Kenny Ducey)

Looking for more best bets? Check out our free NFL picks and our premium subscription for the best picks!

What Time is the Las Vegas Raiders vs. Indianapolis Colts Game?

The Las Vegas Raiders vs. Indianapolis Colts game is at 1:00 PM ET on Sunday, October 5th.

Where is the Las Vegas Raiders vs. Indianapolis Colts Being Played?

This game will be played at Lucas Oil Stadium.

How Can I Watch Raiders vs. Colts?

You can watch Raiders vs. Colts on FOX.

Can the Raiders Beat the Colts?

Yes, after breaking down the matchup, not only are the Raiders live to cover the spread, but they can potentially steal a win on the road here.

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Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
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